FX2149

  Cat. No.:  DC73145   Featured
Chemical Structure
1842427-90-0
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More than 5000 active chemicals with high quality for research!
Field of application
FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
Cas No.: 1842427-90-0
Chemical Name: Benzamide, N-propyl-3-[(3-pyridinylsulfonyl)amino]-
Synonyms: Benzamide, N-propyl-3-[(3-pyridinylsulfonyl)amino]-
SMILES: C(NCCC)(=O)C1=CC=CC(NS(C2=CC=CN=C2)(=O)=O)=C1
Formula: C15H17N3O3S
M.Wt: 319.37878203392
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
Cat. No. Product name Field of application
DC73146 MK-1468 MK-1468 is a potent, selective, brain-penetrant LRRK2 inhibitor with IC50 of 0.4 nM (G2019S LRRK2), potently inhibits the phosphorylation of LRRK2 serine 935 (pSer935) in hPBMCs with IC50 of 2.8 nM.
DC73145 FX2149 FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP.
DC48117 EB-42486 EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM).
DC10360 MLi-2 MLi-2 is an a potent, highly selective, orally available, brain penetrant inhibitor of LRRK2 with an IC50 of 0.76 nM.
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