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Home > Inhibitors & Agonists > Metabolic Enzyme/Protease > NADPH Oxidase (NOX)

GLX7013114

  Cat. No.:  DC70434   Featured
Chemical Structure
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Field of application
GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.GLX7013114 displays no activity against Nox 1/2/3/5, as well as Glucose oxidase and Xanthine oxidase; does not display any redox activity.GLX7013114 inhibits TGFβ-induced upregulation of mesenchymal genes.GLX7013114 protected islet cells against both cytokines and high glucose + palmitate.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: GLX7013114
Synonyms: GLX-7013114
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70434 GLX7013114 GLX7013114 (GLX-7013114) is a novel selective NADPH oxidase 4 (Nox4) inhibitor with IC50 of 0.3 uM in in CJ Nox4 HEK 293 cell asays.GLX7013114 displays no activity against Nox 1/2/3/5, as well as Glucose oxidase and Xanthine oxidase; does not display any redox activity.GLX7013114 inhibits TGFβ-induced upregulation of mesenchymal genes.GLX7013114 protected islet cells against both cytokines and high glucose + palmitate.
DC10841 VAS 2870 VAS2870 is a selective inhibitor of the NADPH oxidases.
DC11009 GLX351322 GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.
DC8118 GKT137831(Setanaxib) GKT137831 is a novel and specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM; a potent inhibitor of fibrosis and hepatocyte apoptosis.
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