GRK6 inhibitor 18
Cat. No.: DC70442
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Chemical Structure
2677786-61-5
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Field of application
GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases.GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib.
| Cas No.: |
2677786-61-5 |
| Chemical Name: |
GRK6 inhibitor 18 |
| SMILES: |
COC1=CC=CC2=NC(NCC3=CC=C(Cl)C=C3OC)=NC(NC4=NNC(CC)=C4)=C12 |
| Formula: |
C22H23ClN6O2 |
| M.Wt: |
438.916 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: |
1. David E Uehling, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147. |
| Description: |
GRK6 inhibitor 18 is a potent, and selective GRK6 inhibitor with IC50 of 8 nM.
GRK6 inhibitor 18 displays >1,000-fold selectivity over Aurora A, as well as high selectivity against a panel of 85 kinases.
GRK6 inhibitor 18 has potent cellular target engagement and antiproliferative activity against MM cells (IC50=0.4-0.46 uM) and is synergistic with bortezomib. |
| References: |
1. David E Uehling, et al. J Med Chem. 2021 Aug 12;64(15):11129-11147. |
MSDS
COA
| LOT NO. |
DOWNLOAD |
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| 2018-0101 |
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