KC-130|CAS |DC Chemicals

Cas No.:
Chemical Name:	KC-130
SMILES:	O=S(C1=CC(C2=CC=CC=C2)=CC=C1)(NC3=CC=C(F)C(N4N=NC(C5=CN=C(NN=C6OC7CN(C(C=C)=O)CC7)C6=C5)=C4)=C3F)=O
Formula:	C₃₃H₂₆F₂N₈O₄S
M.Wt:	668.68

MSDS

Cat. No.	Product name	Field of application
DC74345	TC13172	TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells.
DC74344	KC-130	KC-130 (KC130, ZAK inhibitor 8) is a potent, selective and covalent leucine-zipper and sterile-α motif kinase (ZAK) inhibitor with IC50 of 11.5 nM.
DC72550	NecroIr1	NecroIr1 is an iridium(III) complex, serves as necroptosis inducers in Cisplatin-resistant lung cancer cells (A549R). NecroIr1 selectively accumulates in mitochondria, leading to oxidative stress and loss of mitochondrial membrane potential (MMP). NecroIr1 activates receptor-interacting serine-threonine kinase 3 (RIPK3) and Mixed Lineage Kinase (MLKL), and regulates CDK4 expression.