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LBW242

Cat. No.: DC46504

Chemical Structure

867324-12-7

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Field of application

LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic IAP inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	867324-12-7
Chemical Name:	LBW242
SMILES:	[H][C@@]1(C2)[C@](CCN1C([C@H](C3CCCCC3)NC([C@H](C)NC)=O)=O)([H])CCN2CCC4=CC=CC=C4
Formula:	C₂₇H₄₂N₄O₂
M.Wt:	454.65
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47155	SM-433	SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM. (patent WO2008128171A2).
DC46504	LBW242	LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic IAP inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells.
DC11695	AT-IAP	A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively.

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