lurasidone|cas 367514-87-2|supplier DC Chemicals

Cas No.:	367514-87-2
Chemical Name:	(3aR,4S,7R,7aS)-2-(((1R,2R)-2-((4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)methyl)cyclohexyl)methyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
Synonyms:	SM13496; SM-13496; SM 13496; SM13,496; SM-13,496; SM 13,496; Lurasidone, trade name: Latuda
SMILES:	C1CC[C@H]([C@@H](C1)CN2CCN(CC2)C3=NSC4=CC=CC=C43)CN5C(=O)[C@H]6[C@@H]7CC[C@@H](C7)[C@H]6C5=O
Formula:	C₂₈H₃₆N₄O₂S
M.Wt:	492.682
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Lurasidone is a novel psychotropic agent that has been shown in studies of cloned human receptors to be an antagonist at the 5-HT2A receptor, with a binding affinity (Ki; the dissociation constant of the inhibitor) of 0.47, and a Ki of 0.99 at the D2 receptor. It also has a very high affinity For the 5-HT7 receptor, which is nearly identical to its affinity For the 5-HT2A receptor. In addition, lurasidone has moderate partial agonist effects at the 5-HT1A receptor and moderately potent antagonist effects at α2c receptor subtypes . For the detailed information about the solubility of lurasidone in water, the solubility of lurasidone in DMSO, the solubility of lurasidone in PBS buffer, the animal experiment（test） of lurasidone,the in vivo,in vitro and clinical trial test of lurasidone,the cell experiment（test） of lurasidone,the IC50, EC50 and Affinity of lurasidone, please contact DC Chemicals.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47777	FPPQ	FPPQ is a dual-acting 5-HT3 (Ki = 0.9 nM) and 5-HT6 (Ki = 3 nM) receptor antagonist with antipsychotic and procognitive properties.
DC47056	Usmarapride	Usmarapride (SUVN-D4010) is a selective 5-HT4 receptor ligand with EC50 value 27.5nM, intended for the symptomatic research of Alzheimer's disease and other disorders of memory and cognition like attention deficient hyperactivity, Parkinson's and schizophrenia.
DC46838	SB 258719 hydrochloride	SB 258719 (hydrochloride) is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 (hydrochloride) shows apparent partial inverse agonism.
DC46837	Felcisetrag	Felcisetrag (TD-8954) is an orally active, potent and selective 5-HT4 receptor agonist with gastrointestinal prokinetic properties. Felcisetrag has high affinity (pKi =9.4) for human 5-HT4(c) receptors.
DC46498	SB-221284	SB 221284 is a selective 5-HT2C/2B receptor antagonist with pKi values are 6.4, 7.9 and 8.6 for 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. SB 221284 can be used for the research of neurological disease.
DC46478	DR4485 hydrochloride	DR4485 (hydrochloride) is an orally active and selective 5-HT7 antagonist (pKi=8.14).
DC46462	Renzapride	Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.
DC46454	NAS181	NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.
DC46452	WAY-100135 dihydrochloride	WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.
DC46291	Org37684	Org37684 is a highly potent 5-HT2C receptor agonist (pEC50=8.17). Org37684 exhibits a rank order of potency of 5-HT2C>5-HT2B>5-HT2A. Its selectivity for the 5-HT2C receptor is approximately 2.5 times over the 5-HT2B (pEC50=7.96) and ten times for the 5-HT2A (pEC50=7.11) receptor.