ML315|CAS 1440251-53-5|DC Chemicals

Cas No.:	1440251-53-5
Chemical Name:	5-(1,3-dioxaindan-5-yl)-N-(3,5-dichlorophenyl)methylpyrimidin-4-amine
Synonyms:	5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride;ML 315 hydrochloride;4-Pyrimidinamine, 5-(1,3-benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-;5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinaminehydrochloride;5-(1,3-dioxaindan-5-yl)-N-(3,5-dichlorophenyl)methylpyrimidin-4-amine;ML 315
SMILES:	C1=NC=C(C2=CC=C3OCOC3=C2)C(NCC2=CC(Cl)=CC(Cl)=C2)=N1
Formula:	C₁₈H₁₃Cl₂N₃O₂
M.Wt:	374.220721960068
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC73160	MW01	MW01 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 360 and 14.1 nM, does not inhibit CLK3.
DC73159	ML315	ML315 is a small molecule inhibitor of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases with IC50 of 68, 231, >10,000, 68, 282 and 1156 nM for CLK1/2/3/4 and DYRK1/2, respectively.
DC70440	GPS167	GPS167 is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A.GPS167 promotes the dephoshorylation of SRSF10 and changes its interaction with partner proteins.GPS167 treatment leads to a partial dephosphorylation of SRSF10 and increases the recovery of CLK1 and CLK4.GPS167 impairs the growth of cancer cell line, elicits p53-dependent cytotoxicity.GPS167 is cytotoxic for human colorectal cancer organoids but not normal organoids.