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Nusinersen

  Cat. No.:  DC47280   Featured
Chemical Structure
1258984-36-9
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More than 5000 active chemicals with high quality for research!
Field of application
Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1258984-36-9
Chemical Name: Nusinersen
Synonyms: Nusinersen;ISIS SMNRx;ISIS-SMN(Rx);Nusinersen [USAN:INN];5Z9SP3X666;RNA, (2'-0-(2-methoxyethyi))(p-thio)(m5u-c-a-c-m5u-m5u-m5u-c-a-m5ua- a-m5 u-g-c-m5u-g-g)
SMILES: S=P(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(N)=NC=NC2=3)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(C)=C2)=O)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(N=C(C(C)=C2)N)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C(NC(C(C)=C2)=O)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)OP(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(NC(N)=NC2=3)=O)O1)OCCOC)O)=S)=S)=S)=S)=S)=S)O[C@@H]1[C@@H](COP(O)(O[C@@H]2[C@@H](COP(O)(O[C@@H]3[C@@H](COP(O)(O[C@@H]4[C@@H](COP(O)(O[C@@H]5[C@@H](COP(O)(O[C@@H]6[C@@H](COP(O)(O[C@@H]7[C@@H](COP(O)(O[C@@H]8[C@@H](COP(O)(O[C@@H]9[C@@H](COP(O)(O[C@@H]%10[C@@H](COP(O)(O[C@@H]%11[C@@H](CO)O[C@H]([C@@H]%11OCCOC)N%11C(NC(C(C)=C%11)=O)=O)=S)O[C@H]([C@@H]%10OCCOC)N%10C(N=C(C(C)=C%10)N)=O)=S)O[C@H]([C@@H]9OCCOC)N9C=NC%10C(N)=NC=NC9=%10)=S)O[C@H]([C@@H]8OCCOC)N8C(N=C(C(C)=C8)N)=O)=S)O[C@H]([C@@H]7OCCOC)N7C(NC(C(C)=C7)=O)=O)=S)O[C@H]([C@@H]6OCCOC)N6C(NC(C(C)=C6)=O)=O)=S)O[C@H]([C@@H]5OCCOC)N5C(NC(C(C)=C5)=O)=O)=S)O[C@H]([C@@H]4OCCOC)N4C(N=C(C(C)=C4)N)=O)=S)O[C@H]([C@@H]3OCCOC)N3C=NC4C(N)=NC=NC3=4)=S)O[C@H]([C@@H]2OCCOC)N2C(NC(C(C)=C2)=O)=O)=S)O[C@H]([C@@H]1OCCOC)N1C=NC2C(N)=NC=NC1=2
Formula: C234H340N61O128P17S17
M.Wt: 7127.1942691803
Purity: >95%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Target: SMN2
In Vitro: Nusinersen is an SMN-ASO that increases SMN levels by blocking an intronic splice silencer in SMN2, thereby facilitating the exon 7 inclusion and generation of FL-SMN2 transcripts.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47280 Nusinersen Nusinersen is an antisense oligonucleotide drug that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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