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NVS-BET-1

  Cat. No.:  DC48139   Featured
Chemical Structure
1639115-52-8
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More than 5000 active chemicals with high quality for research!
Field of application
NVS-BET-1 is a BET bromodomain inhibitor that regulates keratinocyte plasticity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1639115-52-8
Chemical Name: Pyrrolo[3,4-c]pyrazol-6(1H)-one, 4-(4-chlorophenyl)-1-cyclopropyl-5-(1,6-dihydro-1,5-dimethyl-6-oxo-3-pyridinyl)-4,5-dihydro-3-methyl-, (4R)-
Synonyms: Pyrrolo[3,4-c]pyrazol-6(1H)-one, 4-(4-chlorophenyl)-1-cyclopropyl-5-(1,6-dihydro-1,5-dimethyl-6-oxo-3-pyridinyl)-4,5-dihydro-3-methyl-, (4R)-;NVS-BET-1
SMILES: N1=C(C)C2[C@@H](C3=CC=C(Cl)C=C3)N(C3C=C(C)C(=O)N(C)C=3)C(=O)C=2N1C1CC1
Formula: C22H21ClN4O2
M.Wt: 408.88
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_32030_DC48139_1639115-52-8
COA
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Cat. No. Product name Field of application
DC72030 GNE-064 GNE-064 (compound 5) is a selective, oral and highly soluble inhibitor of the SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 μM and inhibits SMARCA2 with an EC50 of 0.10 μM. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 μM for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of drug synthesis.
DC48139 NVS-BET-1 NVS-BET-1 is a BET bromodomain inhibitor that regulates keratinocyte plasticity.
DC46835 Ziftomenib Ziftomenib is a menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).
DC46500 I-BET282E I-BET282E is a pan-inhibitor of all eight BET bromodomains, and selectivity over other representative bromodomain-containing proteins. I-BET282E shows pIC50s ranging 6.4-7.7 for BRD2 (BD1/BD2), BRD2 (BD1/BD), BRD3 (BD1/BD), and BRD4 (BD1/BD).
DC46003 GSK097 GSK097 is a potent and selective Inhibitor of the second bromodomain (BD2) of the bromodomain and extra-terminal domain (BET) proteins. GSK097 displays 2000-fold selective for BD2 over BD1 (BRD4 data) with >1 mg/mL solubility in FaSSIF media.
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