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RMC-5552

  Cat. No.:  DC44967   Featured
Chemical Structure
2382768-62-7
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More than 5000 active chemicals with high quality for research!
Field of application
RMC-5552 is a potent and selective inhibitor of mTORC1. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 has anti-cancer activity.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2382768-62-7
Chemical Name: RMC 5552
Synonyms: Rapamycin, 27-​deoxo-​27-​hydroxy-​, 42-​[29-​[6-​[[4-​amino-​3-​(2-​amino-​5-​benzoxazolyl)​-​1H-​pyrazolo[3,​4-​d]​pyrimidin-​1-​yl]​methyl]​-​3,​4-​dihydro-​2(1H)​-​isoquinolinyl]​-​29-​oxo-​5,​8,​11,​14,​17,​20,​23,​26-​octaoxa-​2-​azanonacosanoate]​, (27R)​-
SMILES: C1C=C(C)[C@H](C[C@@]2(CC[C@H]([C@@](O)(O2)C(C(N2CCCC[C@@]2([H])C(=O)O[C@]([H])([C@@H](C[C@@H]2CC[C@H]([C@H](OC)C2)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)N2CC3=CC=C(CN4N=C(C5C6N=C(N)OC=6C=CC=5)C5C(N)=NC=NC4=5)C=C3CC2)C)C[C@@H](O)[C@@H](C=C([C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=1)C)C)=O)=O)C)[H])OC |c:1,t:114,128,130|
Formula: C93H136N10O24
M.Wt: 1778.13
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC44967 RMC-5552 RMC-5552 is a potent and selective inhibitor of mTORC1. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 has anti-cancer activity.
DC41010 PQR626 PQR626 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. PQR626 can be used for the research of neurological disorder.
DC9514 Deforolimus Deforolimus(AP23573; MK-8669; Ridaforolimus) is a selective mTOR inhibitor with IC50 of 0.2 nM; while not classified as a prodrug, mTOR inhibition and FKBP12 binding is similar to rapamycin. IC50 value: 0.2 nM [1] Target: mTOR in vitro: Treatment of HT
DC3118 Torin1 Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
DC3117 Torin2 Torin 2 is a highly potent and selective mTOR inhibitor with IC50 of 0.25 nM, and also exhibits potent cellular activity against ATM/ATR/DNA-PK with EC50 of 28 nM, 35 nM and 118 nM, respectively.
DCAPI1488 Temsirolimus Temsirolimus is an inhibitor of ribosomal protein S6 phosphorylation and inhibits cell growth and clonogenic survival of cells in a concentration-dependent manner.
DC11306 Secorapamycin A(Seco Rapamycin) Seco-rapamycin(Secorapamycin A) is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR..
DC1048 Rapamycin (Sirolimus) Rapamycin (Sirolimus, AY-22989, WY-090217) is a specific mTOR inhibitor with IC50 of ~0.1 nM. -
DC7482 Torkinib (PP242) PP242 is a selective mTOR inhibitor with IC50 of 8 nM; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively; also showed slightly weaker activity against BRD4 (Kd= 1.7 uM).
DC1501 Everolimus Everolimus (RAD001) is an mTOR inhibitor of FKBP12 with IC50 of 1.6-2.4 nM.
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