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SN38 NHS ester

  Cat. No.:  DC71115   Featured
Chemical Structure
2400904-71-2
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Field of application
SN38 NHS ester is the NHS ester derivative of SN38. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis. SN38 NHS ester can be used for the synthesis of antibody-drug conjugates (ADCs).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2400904-71-2
Chemical Name: SN38 NHS ester
Synonyms: Butanedioic acid, 1-[(4S)-4,11-diethyl-3,4,12,14-tetrahydro-9-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl] 4-(2,5-dioxo-1-pyrrolidinyl) ester
SMILES: C(O[C@@]1(CC)C2C=C3C4C(CN3C(=O)C=2COC1=O)=C(CC)C1C(N=4)=CC=C(O)C=1)(=O)CCC(ON1C(=O)CCC1=O)=O
Formula: C30H27N3O10
M.Wt: 589.549488306046
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_35341_DC71115_2400904-71-2
COA
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Cat. No. Product name Field of application
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DC71115 SN38 NHS ester SN38 NHS ester is the NHS ester derivative of SN38. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis. SN38 NHS ester can be used for the synthesis of antibody-drug conjugates (ADCs).
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DC40468 Mc-VC-PAB-SN38 Mc-VC-PAB-SN38 consists a cleavable ADC linker (Mc-VC-PAB) and a DNA topoisomerase I inhibitor (SN38). Mc-VC-PAB-SN38 can be used in the synthesis of antibody-drug conjugates (ADCs).
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