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SQ-3

  Cat. No.:  DC72517  
Chemical Structure
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Field of application
SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM). [18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: SQ-3
SMILES: CN(C)C1=CC=C(/C=C/C2=NC3=CC(OCCF)=CC=C3C=C2)C=C1
Formula: C21H21FN2O
M.Wt: 336.4
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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COA
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Cat. No. Product name Field of application
DC44521 Ezeprogind disulfate Ezeprogind (AZP-2006) disulfate is an orally active neurotrophic inducer. Ezeprogind disulfate targets all causes of neurodegeneration and is not only aiming at markers such as Abeta protein or tau protein. Ezeprogind disulfate is a potent neuroprotectant and can be used for the research of neurological disorders, including progressive supranuclear palsy (PSP), tauopathies, alzheimer’s and parkinson’s diseases, et al.
DC10217 TRx0237 (LMTX) mesylate TRx 0237 (LMTX™) mesylate is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.
DC11301 ALZ-801 ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.
DC73872 SRI-42667 SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
DC73871 NPT200-11 NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.
DC73870 MeSC-04 MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro.
DC73869 DDQ DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects.
DC73868 CNB-001 CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.
DC72517 SQ-3 SQ-3 is a quinoline analogue, displays moderate selectivity for α-syn aggregates (Ki=39.3 nM) over β-amyloid (Aβ) aggregates (Ki=230 nM). [18F]SQ3 has basic properties as a lead compound for the development of a useful α-syn imaging probe.
DC71941 Neuropeptide Y Neuropeptide Y (NPY), a 36 amino acid peptide widely distributed within central nervous system neurons, is a neuroprotective agent against β-amyloid neurotoxicity which influences the synthesis and the release of nerve growth factor (NGF) by cortical neurons.
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