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STL1267

Cat. No.: DC73861

Chemical Structure

1429024-58-7

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Field of application

STL1267 is a specific, high affinity synthetic agonist of nuclear receptor REV-ERB with EC50 of 0.13 uM and Ki of 0.16 uM, binds directly to the ligand binding domain (LBD) of REV-ERB.

Chemicals Properties Biological activity COA & MSDS Related products Datasheet

Cas No.:	1429024-58-7
Chemical Name:	STL1267
Formula:	C₁₇H₁₁ClN₄O
M.Wt:	322.75

MSDS

Cat. No.	Product name	Field of application
DC73861	STL1267	STL1267 is a specific, high affinity synthetic agonist of nuclear receptor REV-ERB with EC50 of 0.13 uM and Ki of 0.16 uM, binds directly to the ligand binding domain (LBD) of REV-ERB.
DC72132	SR12418	SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research.
DC70458	GSK-2945	GSK-2945 is a potent and selective small molecule Rev-Erbα agonist with EC50 of 50 nM, displays >1,000-fold selectivity over LXRα; inhibits LPS induction of IL-6 production and to upregulate expression of ABCA1 in human THP-1 cells; demonstrates in vivo bioavailability and orally active.

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