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Vazegepant

  Cat. No.:  DC47057   Featured
Chemical Structure
1337918-83-8
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More than 5000 active chemicals with high quality for research!
Field of application
Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1337918-83-8
Chemical Name: Vazegepant
SMILES: CN1CCC(N2CCN(C([C@H](NC(N3CCC(C4=CC(C=CC=C5)=C5NC4=O)CC3)=O)CC6=CC(C=NN7)=C7C(C)=C6)=O)CC2)CC1
Formula: C36H46N8O3
M.Wt: 638.80
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Leonard KA, et al. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929. [2]. Gene M Dubowchik,Charles M Conway,Alison W Xin.Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.
Description: Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine[1][2].
References: [1]. Leonard KA, et al. Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2020 Mar 26;63(6):2915-2929. [2]. Gene M Dubowchik,Charles M Conway,Alison W Xin.Blocking the CGRP Pathway for Acute and Preventive Treatment of Migraine: The Evolution of Success.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC48154 SUN B8155 SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis.
DC47057 Vazegepant Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine.
DC46162 Vazegepant hydrochloride Vazegepant (BHV-3500) hydrochloride is a highly soluble CGRP receptor antagonist. Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation.
DC9396 Olcegepant Olcegepant(BIBN 4096; BIBN 4096BS) is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor(IC50= 0.03 nM).
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