xl-647|XL647|supplier DC Chemicals

Cas No.:	781613-23-8
Chemical Name:	N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
Synonyms:	EXEL-7647,xl-647,xl 647
SMILES:	[H][C@@]12[C@@](C[C@@H](COC3=CC4=C(C(NC5=C(F)C(Cl)=C(Cl)C=C5)=NC=N4)C=C3OC)C2)([H])CN(C)C1
Formula:	C₂₄H₂₅Cl₂FN₄O₂
M.Wt:	491.39
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

For the detailed information about the solubility of xl-647 in water, the solubility of xl-647 in DMSO, the solubility of xl-647 in PBS buffer, the animal experiment（test） of xl-647,the in vivo,in vitro and clinical trial test of xl-647,the cell experiment（test） of xl-647,the IC50, EC50 and Affinity of xl-647, please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC3129	xl647	XL647 is a novel spectrum-selective kinase inhibitor for EGFR, ErbB2, KDR, Flt-4 and EphB4 with IC50 of 0.3 nM, 16 nM, 1.5 nM, 8.7 nM and 1.4 nM, respectively.
DC11722	PF-06459988	PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
DC11721	PF-06747775	A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.

xl647