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ZN-c3

  Cat. No.:  DC46399   Featured
Chemical Structure
2376146-48-2
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More than 5000 active chemicals with high quality for research!
Field of application
ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2376146-48-2
Chemical Name: ZN-c3
Synonyms: ZN-C3;ZN-C3 [WHO-DD];9J13XU96Z1;3H-Pyrazolo(3,4-d)pyrimidin-3-one, 1-((7R)-7-ethyl-6,7-dihydro-7-hydroxy-5H-cyclopenta(b)pyridin-2-yl)-1,2-dihydro-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-2-(2-propen-1-yl)-;ZN-c3
SMILES: O[C@@]1(CC)C2C(=CC=C(N3C4C(=CN=C(NC5C=CC(=CC=5)N5CCN(C)CC5)N=4)C(N3CC=C)=O)N=2)CC1
Formula: C29H34N8O2
M.Wt: 526.632665157318
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
Target: IC50: 3.9 nM (Wee1)[1]
In Vivo: ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent[1]. ZN-c3 shows excellent exposures and bioavailability in the dog PK study[1].
In Vitro: ZN-c3 IC50 is 103 nM in H23c cells[1].
References: [1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC70350 Debio 0123 Debio 0123 (Debio0123) is a potent, orally available, and highly selective Wee1 kinase inhibitor with IC50 of 0.8 nM, Ki of 0.1 nM.Debio 0123 is highly selective to Wee1 on 465 selected kinases in a cellfree system, does not inhibit Plk1 and Plk2, as also reported in recent publications for AZD1775.Debio 0123 exhibits in vitro growth inhibition activity in a broad number of human cancer cell lines (IC50= 0.109 to 7.08 uM).Debio 0123 prevent CDC2 / Cdk1 phosphorylation, induces γH2AX and enhances phosphorylation of histone H3.Debio 0123 induces apoptosis through mitotic catastrophe following cell cycle progression despite accumulation of unrepaired DNA damage both in vitro and in vivo.
DC46399 ZN-c3 ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
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