Cat. No. | Product name | CAS No. |
DC32583 |
CL2A-SN-38
Featured
CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate |
1279680-68-0 |
DC40172 |
DC41
DC41 is a DC1 derivative. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. |
1354787-69-1 |
DC40368 |
Luisol A
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, anthraquinone antibiotic analog, is an ADC Cytotoxin. |
225110-59-8 |
DC40434 |
Boc-NMe-Val-Val-Dil-Dap-OH
Boc-NMe-Val-Val-Dil-Dap-OH is an ADC Cytotoxin. |
|
DC40435 |
Boc-Val-Dil-Dap-OH
Boc-Val-Dil-Dap-OH is an ADC Cytotoxin. |
|
DC40444 |
Boc-Val-Dil-Dap-Phe-OMe
Boc-Val-Dil-Dap-Phe-Ome is an ADC Cytotoxin. |
|
DC40451 |
Diacetyl Agrochelin
Diacetyl Agrochelin is an acetyl derivative of Agrochelin, which is produced by the fermentation of a marine Agrobacterium sp. Diacetyl Agrochelin has cytotoxic activity in tumor cell lines. |
247115-75-9 |
DC40455 |
Puwainaphycin F
Puwainaphycin F, a cyanobacterial cyclic lipopeptide, is a moderate cytotoxin isolated from the soil cyanobacterium Cylindrospermum alatosporum C24/89. Puwainaphycin F causes necrotic cell death to mammalian cells via cell membrane permeabilization and subsequent unusual actin relocalization. |
1379577-47-5 |
DC40467 |
Mytoxin B
Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002. Mytoxin B induces cell apoptosis via PI3K/Akt pathway. |
105049-15-8 |
DC40469 |
Muscotoxin A
Muscotoxin A is an?ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death. |
1653999-47-3 |
DC41129 |
Sandramycin
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity. |
100940-65-6 |
DC39818 |
CL2-SN-38(DCA)
Featured
CL2-SN-38 is a cleavable linker-based antibody-drug conjugate (ADC) containing the topoisomerase I inhibitor SN-38 and a maleimidocaproyl linker. CL2-SN-38 has been linked to tumor-selective human monoclonal antibodies, such as anti-CEACAM5 (hMN-14) to target SN-38 to tumor sites and improve its solubility. CL2-SN-38 linked to hMN-14 binds (Kd = 1.4 nM) and is cytotoxic to LoVo human colon adenocarcinoma cells (IC50 = 5.3 nM). CL2-SN-38 linked to hMN-14 increases survival in a colon carcinoma mouse model of lung metastasis. |
1036969-20-6 |
DC42430 |
Trastuzumab emtansine
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer. |
1018448-65-1 |
DC44783 |
7-Aminomethyl-10-methyl-11-fluoro camptothecin
7-Aminomethyl-10-methyl-11-fluoro camptothecin is a cytotoxin of MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin. 7-Aminomethyl-10-methyl-11-fluoro camptothecin can be used for the synthesis of camptothecin antibody-drug conjugate (ADC). |
2378616-23-8 |
DC44784 |
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC). |
2414594-29-7 |
DC44785 |
7-MAD-MDCPT
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs). |
765871-81-6 |
DC45523 |
Seco-DUBA hydrochloride
Seco-DUBA hydrochloride is a toxin for ADC drug SYD985. |
1795733-93-5 |
DC45695 |
Thailanstatin A
Featured
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC. |
1426953-21-0 |
DC57041 |
N-Me-L-Ala-maytansinol
Featured
N-Me-L-Ala-maytansinol is a maytansine derivative. .N-Me-L-Ala-maytansinol can be used for synthesis of antibody-drug conjugate (ADC). |
77668-69-0 |
DC46215 |
Tubulysin IM-1
Tubulysin IM-1 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins. |
|
DC46252 |
Azonafide-PEABA
Azonafide-PEABA is a cytotoxic drug moiety. |
|
DC46260 |
DMEA-PNU-159682
DMEA-PNU-159682 (molecule D12) is a ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682. |
1799421-48-9 |