DC47594 |
Bictegravir Sodium |
Bictegravir (GS-9883) Sodium is a novel and potent inhibitor of HIV-1 integrase, specifically targets IN strand transfer activity with an IC50 of 7.5 nM. |
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DC47595 |
Zanamivir-Cholesterol Conjugate |
Zanamivir–cholesterol conjugate is a long-acting neuraminidase inhibitor with potent efficacy against drug-resistant influenza viruses. |
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DC47601 |
PMEDAP |
PMEDAP is a potent inhibitor of human immunodeficiency virus (HIV) replication. PMEDAP has anti-murine cytomegalovirus (MCMV) activity. PMEDAP is a very potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality. |
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DC47602 |
Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium |
Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. |
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DC47603 |
Tenofovir-C3-O-C15-CF3 ammonium |
Tenofovir-C3-O-C15-CF3 (ammonium) exhibits substantially longer t1/2 values than tenofovir in human liver microsomes, potent anti-HIV activity in vitro, and enhances pharmacokinetic properties in vivo. |
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DC47604 |
GPS491
Featured
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GPS491 (EC50 = 0.47 μM) suppresses expression of the HIV-1 structural protein Gag and alters HIV-1 RNA accumulation, decreasing the abundance of RNAs encoding the structural proteins while increasing levels of viral RNAs encoding the regulatory proteins. |
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DC47605 |
HIV-1 inhibitor-9 |
HIV-1 inhibitor-9 is found to be potent inhibitor against the wild-type (WT) HIV-1 strain or multiple NNRTI-resistant strains at low nanomolar levels. |
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DC47606 |
Melliferone |
Melliferone is a triterpenoid found in Brazilian propolis. |
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DC47607 |
Antiviral agent 9 |
Antiviral agent 9 reaches a single-digit picomolar EC50 value (0.006 nM) against HIV-1 and nearly 300-fold higher selectivity index (SI) compared to tenofovir alafenamide fumarate (TAF). |
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DC47640 |
Fungicide5 |
Fungicide5 is a fungicide candidate targeting succinate dehydrogenase (Ki = 0.095 μM). |
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DC47641 |
Benzyl 2-hydroxy-6-methoxybenzoate |
Benzyl 2-hydroxy-6-methoxybenzoate shows the strongest antifungal effect, with IC50 of 25–26 μg/mL for both fungal strains. |
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DC47642 |
Antifungal agent 20 |
Antifungal agent 20 exhibits remarkable antifungal activity against Colletotrichum gloeosprioides, Rhizoctonia solani, Phytophthora nicotianae var. nicotianae, Diplodia pinea, Colletotrichum acutatum, and Fusarium oxysporum f. sp. niveum. |
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DC47643 |
Phenazine-1-carboxylic acid |
Phenazine-1-carboxylic acid exhibits strong antifungal activity against phytopathogenic fungi. |
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DC47644 |
5-epi-Jinkoheremol |
5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin. |
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DC47645 |
Antifungal agent 18 |
Antifungal agent 18 is a novel antifungal agent for the treatment of fungal infection. |
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DC47646 |
Antifungal agent 15 |
Antifungal agent 15 has the most potent activity with EC50 values of 0.52 and 0.50 μg/mL against S. sclerotiorum and B. cinerea, respectively. |
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DC47647 |
Antifungal agent 14 |
Antifungal agent 14 exhibits broad-spectrum activity against the fungal strains with excellent minimum inhibitory concentration values. |
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DC47648 |
Nystatin A3 |
Nystatin A3, produced by Streptomyces noursei, a biologically active component of nystatin complex. Antibiotic activity |
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DC47649 |
Fungicide4 |
Fungicide4 shows the high activity against the P. infestans strain. |
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DC47650 |
Debneyol |
Debneyol exhibits more potent fungicidal activity than validamycin. |
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DC47651 |
Antifungal agent 13 |
Antifungal agent 13 exhibits remarkable antifungal activity against Sclerotinia sclerotiorum with an EC50 value of 1.25 mg/L. |
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DC47652 |
Antifungal agent 19 |
Antifungal agent 19 shows the potent antifungal activity (EC50 = 0.72 μM). |
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DC47653 |
Antifungal agent 17 |
Antifungal agent 17 exhibits excellent antifungal properties against B. cinerea with an EC50 value of 2.86 μg/mL. |
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DC47654 |
Antifungal agent 16 |
Antifungal agent 16 displays considerable antibacterial activity and superior antifungal activity with reference to ciprofloxacin and fluconazole, respectively. |
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DC47655 |
Antifungal agent 12 |
Antifungal agent 12 is a novel fluconazole-based compound with promising antifungal activities. |
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DC47656 |
Antifungal agent 11 |
Antifungal agent 11 shows the promising antifungal activity. |
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DC47663 |
WIN 54954 |
WIN 54954 is a broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections. |
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DC47723 |
Decamethoxine |
Decamethoxine (Septefril) is a cationic gemini surfactant. Decamethoxine exhibits strong bactericidal and fungicidal effects. Decamethoxine modifies the permeability of the microbial cell membrane, resulting in the destruction and death of diverse microorganisms. |
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DC47724 |
Hikizimycin |
Hikizimycin is a potent anthelmintic and antibacterial natural product. |
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DC47725 |
ARX-1796 |
ARX-1796 (AV-006), an Avibactam prodrug, is an orally bioavailable β-lactamase inhibitor. Avibactam has a spectrum of inhibition of class A and C β-lactamases, including ESBLs, AmpC and Klebsiella pneumoniae carbapenemase (KPC) enzymes. |
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