DC47726 |
Antistaphylococcal agent 3 |
Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent. |
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DC47727 |
Antistaphylococcal agent 2 |
Antistaphylococcal agent 2 is an antistaphylococcal therapeutic agent. |
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DC47728 |
Antistaphylococcal agent 1 |
Antistaphylococcal agent 1 is an antistaphylococcal therapeutic agent. |
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DC47729 |
Antibacterial agent 28 |
Antibacterial agent 28 is a potential antibacterial candidate for combating MRSA infections (MICs = 0.5–2 μg/mL). |
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DC47730 |
Antitubercular agent-10 |
Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM. |
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DC47731 |
Antibacterial agent 30 |
Antibacterial agent 30 demonstrates excellent in vitro activity against Xoo with EC50 value of 1.9 μg/mL. |
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DC47732 |
Antibacterial agent 31 |
Antibacterial agent 31 shows the antibacterial activity against rice bacterial leaf streak. |
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DC47733 |
Antitubercular agent-9 |
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM. |
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DC47734 |
Brodimoprim |
Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria. |
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DC47735 |
Uvaretin |
A mixture of uvaretin and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM).
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DC47736 |
Targeting the bacterial sliding clamp peptide 46 |
Targeting the bacterial sliding clamp peptide 46 is a short peptide targeting the bacterial sliding clamp(SC), inhibiting SC-dependent DNA synthesis. |
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DC47737 |
Isouvaretin |
A mixture of uvaretin and isouvaretin exhibits significant antibacterial activity against B. subtilis (EC50 8.7 μM) and S. epidermidis (IC50 7.9 μM).
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DC47738 |
(8′α,9′β-Dihydroxy)-3-farnesylindole |
(8'α,9'β-Dihydroxy)-3-farnesylindole shows strong inhibitory activity (EC50 9.8 μM) against B. subtilis. |
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DC47739 |
JPD447 |
JPD447, a MAC-0547630 derivative, is a novel class of UppS inhibitor to potentiate β-lactam antibiotics. |
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DC47740 |
Urease-IN-1 |
Urease-IN-1 is an urease inhibitor with an IC50 value of 2.21 ± 0.45 µM. |
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DC47741 |
LpxA-IN-1 |
LpxA-IN-1 is a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor (IC50 2 nM) with activity against Pseudomonas aeruginosa (MIC 8 μg/mL). |
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DC47742 |
Antibacterial agent 63 |
Antibacterial agent 63, a conjugate of aztreonam to a siderophore mimetic, shows activity against gram-negative bacteria. |
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DC47743 |
Anti gram-positive/negative bacteria agent 1 |
Anti gram-positive/negative bacteria agent 1 is an antibiotic conjugate with an artificial MECAM-based siderophore. |
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DC47744 |
Antibacterial agent 62 |
Antibacterial agent 62 is a novel redox cycling antituberculosis chemotype with potent bactericidal activity against growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria. |
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DC47745 |
NBTIs-IN-4 |
NBTIs-IN-4 demonstrates potent antibacterial activity against diverse Gram-positive pathogens, inhibition of both DNA gyrase and topoisomerase IV, a low frequency of resistance. |
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DC47746 |
MDP1 |
MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa. |
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DC47747 |
MDP1 acetate |
MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa. |
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DC47753 |
Lithium Chloride |
Lithium Chloride inhibits the replication of type 1 and type 2 Herpes simplex virus at concentrations which permitted host cell replication. Lithium chloride also prevents glucocorticoid-induced osteonecrosis of femoral heads and strengthens mesenchymal stem cell activity in rats. |
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DC47755 |
Bleomycin A5 hydrochloride |
Bleomycin A5 hydrochloride is an anti-neoplastic glycoprotein antibiotic. Bleomycin A5 suppresses Drp1‑mediated mitochondrial fission and induces apoptosis in human nasal polyp‑derived fibroblasts. |
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DC58060 |
VV116 (non-deuterated)
Featured
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non-deuterated form of VV116.VV116 is an oral drug candidate of nucleoside analog against SARS-CoV-2. |
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DC47865 |
β-Rubromycin |
β-Rubromycin is a potent and selective inhibitor of human immunodeficiency virus-1 (HIV-1) RNA-directed DNA polymeras (reverse transcriptase). β-Rubromycin is a class of quinone antibacterials. |
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DC47866 |
β-Lactamase-IN-6 |
β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity. |
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DC47874 |
Vanillinbananin |
Vanillinbananin is an effective inhibitor of the ATPase activity of the SARS Coronavirus helicase with an IC50 value of 0.68 μM. |
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DC47891 |
T-2307 |
T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) . |
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DC47906 |
SARS-CoV-2-IN-10 |
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for therapeutic intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals. |
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