| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9766 | LY3177833 Featured | LY3177833 is a novel CDC7 inhibitor,CDC7/DBF4 IC50 = 3.3 nM, pMCM2 (S53) IC50 = 290 nM and IVTI TEC70 = 1.6 mcM. |
|
| DC12261 | LY3295668 (AK-01) | LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. |
|
| DC9741 | Mad2 inhibitor-1 (M2I-1) Featured | Mad2 Inhibitor-1 (M2I-1) is a small molecule protein-protein interaction inhibitor targeting the mitotic spindle assembly checkpoint. |
|
| DC11141 | ME0328 Featured | ME0328 is an inhibitor of PARP3 (IC50 = 0.89 µM), which is a regulator of DNA repair and mitotic progression. |
|
| DC9050 | Melphalan Featured | Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA. |
|
| DC4182 | Temozolomide Featured | Methazolastone (Temozolomide, Temodar, Temodal) is a DNA damage inducer. |
|
| DC8935 | Mitomycin C Featured | Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells. |
|
| DC1070 | MK-1775(AZD-1775,Adavosertib) Featured | MK-1775 is a potent and selective Wee1 inhibitor with IC50 of 5.2 nM. |
|
| DC4179 | Niraparib(MK4827) free base Featured | MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. |
|
| DC9862 | Niraparib(MK4827) hydrochloride Featured | MK-4827 is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. |
|
| DC9576 | Niraparib tosylate Featured | MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1. |
|
| DC7466 | MK-5108 | MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM; 220- and 190-fold more selective for Aurora A than Aurora B/C. |
|
| DC8594 | ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. |
|
| DC7771 | ML216 Featured | ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. |
|
| DC9365 | MLN8054 Featured | MLN8054 is a potent and selective inhibitor of Aurora A with IC50 of 4 nM; exhibits more than 40-fold selective for Aurora A than Aurora B. |
|
| DC2016 | MLN8237 (Alisertib) Featured | MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM. |
|
| DC8659 | MN-64 Featured | MN-64 is a inhibitor of tankyrases, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition. |
|
| DC7470 | MPI-0479605 Featured | MPI-0479605 is an ATP competitive and selective inhibitor of mitotic kinase Mps1 with IC50 of 1.8 nM, >40-fold selectivity over other kinases. |
|
| DC8119 | Mps1-IN-2 Featured | Mps1-IN-2 is a potent Mps1 kianse inhibitor with IC50 value of 145 nM. |
|
| DC10627 | MSC2530818 Featured | MSC2530818, a CDK8 inhibitor with the IC50 of 2.6 nM, displays excellent kinase selectivity, biochemical and cellular potency, microsomal stability, and is orally bioavailable. |
|
| DC11310 | MST312 Featured | MST312 is a telomerase inhibitor (IC50 = 0.67 μM in a TRAP assay). |
|
| DC10332 | Methylthio-DADMe-Immucillin A; MTDIA Featured | MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM. |
|
| DC9298 | thiotepa Featured | N,N’N’-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group. |
|
| DC9936 | NMS-P118 Featured | NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor with excellent ADME and pharmacokinetic profiles and high efficacy in vivo. |
|
| DC9988 | NSC23005 sodium Featured | NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
|
| DC7935 | NU1025 Featured | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). |
|
| DC8214 | NU6027 Featured | NU 6027 inhibits both CDK1 and CDK2 with IC50 values of 2.9 and 2.2 µM, respectively. |
|
| DC10734 | NU2058 Featured | NU2058 is a guanine-based CDK inhibitor with IC50 of 17 μM and 26 μM for CDK2 and CDK1. |
|
| DC8716 | NU6300 | NU6300 is a non-covalent ATP-competitive CDK2 inhibitor (IC50 = 0.16 mM). |
|
| DC3100 | NU-7441 (KU-57788) Featured | NU7441 is a highly potent and selective DNA-PK inhibitor with IC50 of 14 nM and also inhibits PI3K with IC50 of 5 μM. |
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