Cat. No. | Product name | CAS No. |
DC10953 |
DZ-2384
DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types. |
1403850-91-8 |
DC9270 |
Eg5 Inhibitor III(Dimethylenastron)
Featured
Eg5 Inhibitor III, Dimethylenastron is a cell-permeable quinazoline-thione compound that acts as a strong, specific, and reversible inhibitor of the microtubule-stimulated ATPase activity of the mitotic motor, Eg5. |
863774-58-7 |
DC4198 |
Epothilone B
Featured
Epothilone B is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. |
152044-54-7 |
DCAPI1539 |
Eribulin Mesylate
Featured
Eribulin is an anticancer drug marketed by Eisai Co. under the trade name Halaven. Eribulin is also known as E7389 and ER-086526, and also carries the US NCI designation NSC-707389. It is used to treat certain patients with breast cancer and liposarcoma. |
441045-17-6 |
DCAPI1516 |
Eribulin
Eribulin Mesylate (E7389 Mesylate), a synthetic analogue of halichondrin B in phase III clinical trials for breast cancer, binds to tubulin and microtubules. |
253128-41-5 |
DC5882 |
Fosbretabulin disodium
Featured
Fosbretabulin disodium(CA 4DP; CA 4P) is a microtubule destabilizing drug, a type of vascular-targeting agent, a drug designed to damage the vasculature (blood vessels) of cancer tumors causing central necrosis. |
168555-66-6 |
DC7812 |
GSK923295
Featured
GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. |
1088965-37-0 |
DC5107 |
SB-715992 (Ispinesib)
Featured
Ispinesib (SB 715992) is a potent mitotic kinesin KSP (Eg5) inhibitor with a Ki and an IC50 of 0.6 and 4.1 nM, respectively. |
336113-53-2 |
DCAPI1510 |
Ixabepilone
Featured
Ixabepilone (Azaepothilone B; BMS 247550) is an epothilone B analog and nontaxane microtubule-stabilizing compound with clinical activity in a range of solid tumors. |
219989-84-1 |
DC9272 |
K 858
Featured
K 858 is an ATP-uncompetitive mitotic kinesin Eg5 inhibitor, which does not effect microtubule dynamics. |
72926-24-0 |
DC12220 |
Kinesore
Kinesore is an inhibitor of the KLC2-SKIP Interaction. |
363571-83-9 |
DC11524 |
Mavacamten(MYK-461)
Featured
Mavacamten(MYK-461)is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain. |
1642288-47-8 |
DC10711 |
ML-327
Featured
ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT). |
1883510-31-3 |
DC2082 |
Monastrol
Featured
Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 μM |
329689-23-8 |
DC11241 |
MP-HJ-1b
MP-HJ-1b is a novel potent inhibitor of microtubule and tumor cell growth, binds the colchicine pocket at the intra-dimer interface, depolymerizes microtubules and affects spindle formation. |
|
DC8715 |
NSC305787
NSC305787 is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. |
785718-37-8 |
DC7023 |
Ombrabulin
Featured
Ombrabulin (AVE8062) hydrochloride is a synthetic derivative of CA-4-P, which inhibits growth in a large number of drug-resistant animal tumors and carcinogen-induced tumors. |
181816-48-8 |
DC10981 |
Plocabulin
Plocabulin (PM060184) is a novel tubulin-binding agent binding to αβ-tubulin dimer with nanomolar affinity, inhibits a panel of 23 tumor cell lines with GI50 of 20 pM-5 nM. |
960210-99-5 |
DC8224 |
Lifitegrast(SAR 1118)
Featured
SAR 1118 is a potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonist for treating dry eye. |
1025967-78-5 |
DC5137 |
SB 743921
Featured
SB743921 is a kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, almost no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. |
940929-33-9 |
DC10390 |
TD139
Featured
TD139 is a novel high-affinity inhibitor of the galectin-3 carbohydrate binding domain with a Kd of 14 nM. |
1450824-22-2 |
DC9489 |
Tirofiban (hydrochloride monohydrate)
Featured
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist |
150915-40-5 |