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E3 Ligase Ligand-Linker Conjugate

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Cat. No. Product Name Field of Application Chemical Structure
DC48790 Lenalidomide-C5-NH2 TFA Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.
DC50219 NJH-2-030 NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications.
DC50053 E3 Ligase Ligand-Linker Conjugates 20 Featured Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
DC50055 Thalidomide-NH-C6-NH2 Featured Thalidomide-NH-C6-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC50056 Thalidomide-PEG2-C2-NH2 Featured Thalidomide-PEG2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
DC50057 E3 ligase Ligand-Linker Conjugates 30 Featured E3 ligase Ligand-Linker Conjugates 30 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 30 can be used to design PROTAC MDM2 degrader[1].
DC50058 VH032-C3-NH2((S,R,S)-AHPC-C3-NH2) Featured (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader[1].
DC50059 (S,R,S)-AHPC-C4-NH2 Featured (S,R,S)-AHPC-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC[1].
DC50060 (S,R,S)-AHPC-C2-NH2 dihydrochloride Featured (S,R,S)-AHPC-C2-NH2 dihydrochloride incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-OH can be used in the synthesis of a series of PROTACs[1].
DC50062 Thalidomide-NH-PEG1-C2-NH2 Featured Thalidomide-NH-PEG1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
DC50063 (S,R,S)-AHPC-C6-NH2 Featured PROTAC building block.
DC50064 (S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) Featured (S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.
DC50065 （S,R,S)-AHPC-CO-CI-Br Featured （S,R,S)-AHPC-CO-CI-Br is a novel protac building block,
DC50066 （S,R,S)-AHPC-acetamido-O-C2-amine HCI Featured （S,R,S)-AHPC-acetamido-O-C2-amine HCI is a novel PROTAC building block.
DC50068 (S,R,S)-AHPC-Me-C10-NH2 Featured (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) Featured (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50070 (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) Featured (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50071 (S,R,S)-AHPC-PEG2-NH2 hydrochloride E3 ligase Ligand-Linker Conjugates 6) Featured (S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50072 (S,R,S)-AHPC-PEG3-NH2 （E3 ligase Ligand-Linker Conjugates 5） Featured (S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
DC50073 (S,R,S)-AHPC-PEG3-NH2 hydrochloride（E3 ligase Ligand-Linker Conjugates 5） Featured (S,R,S)-AHPC-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
DC50074 (S,R,S)-AHPC-Me-C1-NH2 Featured (S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
DC50075 (S,R,S)-AHPC-Me-C2-NH2 Featured (S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
DC50076 (S,R,S)-AHPC-Me-C3-NH2 Featured (S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
DC50077 (S,R,S)-AHPC-Me-C4-NH2 Featured (S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
DC50078 (S,R,S)-AHPC-Me-C8-NH2 Featured (S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
DC50079 Thalidomide-O-amido-C5-NH2 Featured Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
DC71952 Pomalidomide-C12-NH2 hydrochloride Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1. PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader.
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