| DC49776 |
5-Hydroxyindole-3-acetic acid-13C6 |
5-Hydroxyindole-3-acetic acid-13C6 is the 13C-labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors. |
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| DC49777 |
Nicotinamide-13C6 |
Nicotinamide-13C6 (Niacinamide-13C6) is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1. |
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| DC49778 |
TMC-205 |
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter. |
|
| DC49779 |
7-Hydroxypestalotin |
7-Hydroxypestalotin (LL-P880β) is a fungal metabolite. |
|
| DC49780 |
Vitamin K1-d4 |
Vitamin K1-d4 (Phylloquinone-d4) is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism. |
|
| DC49781 |
Cholic acid-13C |
Cholic acid-13C is the 13C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. |
|
| DC49782 |
1,3,7-Trimethyluric acid |
1,3,7-Trimethyluric acid is the metabolite of caffeine. The metabolic ratio 1,3,7-Trimethyluric acid to caffeine can be evaluated as a biomarker to describe variability in CYP3A activity in a cohort. |
|
| DC49783 |
(Rac)-sn-Glycerol 3-phosphate |
(Rac)-sn-Glycerol 3-phosphate is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited. |
|
| DC49784 |
Murideoxycholic acid |
Murideoxycholic acid is a 6 beta-hydroxylated bile acid. |
|
| DC49785 |
Eicosapentaenoic Acid sodium |
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation. |
|
| DC49786 |
Phenylacetyl CoA |
Phenylacetyl CoA is an acceptor oxidoreductase. Phenylacetyl CoA is a membrane-bound molybdenum–iron–sulfur enzyme involved in anaerobic metabolism of phenylalanine in the denitrifying bacterium Thauera aromatica. |
|
| DC49787 |
2-Hydroxypalmitic acid |
2-Hydroxypalmitic acid is an intermediate in phytosphingosine metabolism. |
|
| DC49788 |
1-Aminopropan-2-ol |
1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas. |
|
| DC49789 |
Biliverdin hydrochloride |
Biliverdin hydrochloride is a tetrapyrrolic, water-soluble compound formed by the breakdown of heme. Biliverdin hydrochloride can upregulate the activity of biliverdin reductase which is an enzyme that is a regulator of the innate immune system. |
|
| DC49790 |
Butyrolactone II |
Butyrolactone II is a fungal metabolite isolated from Aspergillus flavipes. |
|
| DC49791 |
F-14329 |
F-14329 is a tetramic acid fungal metabolite. |
|
| DC49792 |
2-Hydroxyestrone-13C6 |
2-Hydroxyestrone-13C6 (Catecholestrone-13C6) is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic. |
|
| DC49793 |
2-Methoxyestrone-13C6 |
2-Methoxyestrone-13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81. |
|
| DC49794 |
Retinol-d6 |
Retinol-d6 (Vitamin A1-d6) is the deuterium labeled Vitamin A. Retinol is an endogenous metabolite. |
|
| DC49795 |
Thiamine-13C3 hydrochloride |
Thiamine-13C3 (Thiamine chloride-13C3) hydrochloride is the 13C-labeled Thiamine (hydrochloride). Thiamine hydrochloride (Thiamine chloride hydrochloride) is an essential micronutrient needed as a cofactor for many central metabolic enzymes. |
|
| DC49796 |
Pyridoxine-13C4 hydrochloride |
Pyridoxine-13C4 (Pyridoxol-13C4) hydrochloride is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. |
|
| DC71013 |
BOC-L-Phenylalanine-13C |
BOC-L-Phenylalanine-13C is a 13C-labeled BOC-L-Phenylalanine. BOC-L-Phenylalanine is a derivative of Phenylalanine. |
|
| DC71190 |
6-trans-12-epi-Leukotriene B4 |
6-trans-12-epi-Leukotriene B4, an arachidonic acid metabolite, is a potent anti-inflammatory agent. |
|
| DC71191 |
9-PAHPA |
9-PAHPA is a fatty acid esters of hydroxy fatty acid (FAHFA). FAHFAs are a new family of endogenous lipids, have antidiabetic and anti-inflammatory effects. |
|
| DC71193 |
Ac-β-Ala-OH |
Ac-β-Ala-OH (N-Acetyl-β-alanine), an abnormal amino acid metabolite, is a mono-N-protected amino acid (MPAA) ligand. |
|
| DC71196 |
Guanidinoethyl sulfonate |
Guanidinoethyl sulfonate (Taurocyamine), a transport antagonist of taurine, induces much urinary taurine excretion with a resulting decrease in the tissue taurine content and readily produces taurine-deficient fetal rats in pregnant rats. Guanidinoethyl sulfonate, a structural analogue of taurine, acts as a competitive inhibitor of taurine transport. |
|
| DC71201 |
L-Kynurenine sulfate |
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. |
|
| DC71210 |
l-α-tocopherol acetate-13C4,d6 |
l-α-tocopherol acetate-13C4,d6 is the 13C- and deuterium-labeled l-α-tocopherol acetate. l-α-tocopherol acetate is a natural tocopherol and has potent antioxidant activities. |
|
| DC71235 |
Cholestenone-13C |
Cholestenone-13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells. |
|
| DC71247 |
SAH-13C5 |
SAH-13C5 (SAH (S-Adenosylhomocysteine)-13C5) is the 13C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM. |
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