| DC66423 |
GA32
Featured
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GA32 (compound 58r) is potent androgen receptor (AR)/glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide (HY-70002) resistance castration-resistant prostate cancer both in vitro and in vivo. |
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| DC66424 |
CSF1R-IN-20
Featured
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CSF1R-IN-20 (compound 7a) is a CSF-1R Inhibitor with an IC50 value of 467 nM. CSF1R-IN-20 inhibits CSF-1R auto-phosphorylation. |
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| DC66425 |
Nav1.8-IN-8
Featured
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Nav1.8-IN-8 (Compound A11) is a Nav1.8 channel inhibitor. Nav1.8-IN-8 may prevent associated diseases mediated by sodium ion channels (NaV). |
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| DC66426 |
PKM2-IN-6
Featured
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PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer. |
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| DC66427 |
URB694
Featured
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URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH. |
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| DC66428 |
Bavisant
Featured
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Bavisant (JNJ-31001074) is an orally active, potent, brain-penetrating and highly selective antagonist of the histamine H3 receptor. Bavisant can be used for attention-deficit hyperactivity disorder (ADHD) research. |
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| DC66429 |
Phenol, 4,4'-(1E)-1,2-ethenediylbis[2-methoxy-
Featured
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| DC66430 |
4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid
Featured
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4-Methyl-4-(pyridin-2-yldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). |
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| DC66431 |
α,α-dimethyl-2-ethoxymethyl-1H-imidazo[4,5-c]quinoline-1-ethanol
Featured
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| DC66432 |
Moclobemide N-Oxide
Featured
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Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm. |
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| DC66433 |
EGFR-IN-80
Featured
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EGFR-IN-80 (compound 30) is an EGFR inhibitor with a pIC50 of 10.6. |
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| DC66434 |
c-Kit-IN-3
Featured
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c-Kit-IN-3 (Compound 18) is a potent and selective c-KIT kinase inhibitor with an IC50s of 4 nM, 8 nM for c-KIT wt and c-KIT T670I, respectively. c-Kit-IN-3 displays great potencies against most of the gain-offunction mutations in the juxtamembrane domain, drugresistant mutations in the ATP binding pocket, and activation loops. |
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| DC66435 |
NS1652
Featured
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NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. |
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| DC66436 |
CYP1B1-IN-7
Featured
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CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC50: 75 nM). CYP1B1-IN-7 also reverses resistance (IC50: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011). |
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| DC66437 |
Firefly luciferase-IN-1
Featured
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Firefly luciferase-IN-1 (compound 48) is a highly potent and reversible inhibitor of firefly luciferase with an IC50 value of 0.25 nM. |
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| DC66438 |
n-[3-(benzyloxy)pyridin-2-yl]benzenesulfonamide
Featured
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| DC66439 |
Antituberculosis agent-5
Featured
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Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosis UDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC50 value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL. |
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| DC66440 |
mPEG-DSPE
Featured
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| DC66441 |
Tubulin inhibitor 11
Featured
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Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis. |
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| DC66442 |
TASK-1-IN-1
Featured
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TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects. |
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| DC66443 |
NDH-1 inhibitor-1
Featured
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NDH-1 inhibitor-1 (compound 27) is a potent NDH-1 inhibitor with pI50 values of <4, 5.40, 6.15 µM for Bovine SMP (submitochondrial particles), Potato SMP and E. coli, respectively. |
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| DC66444 |
Antimalarial agent 17
Featured
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Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides. |
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| DC66445 |
Antimicrobial agent-14
Featured
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Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis. |
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| DC66446 |
Anti-Influenza agent 4
Featured
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Anti-Influenza agent 4 is a potent and selective influenza virus inhibitor with EC50s of 150 nM and 62 nM for strains A/Roma and A/Parma, respectively. |
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| DC66447 |
Antitrypanosomal agent 9
Featured
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Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC50 of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research. |
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| DC66448 |
Neuropeptide Y5 receptor ligand-1
Featured
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Neuropeptide Y5 receptor ligand-1 (compound 54), a carbazole derivative, is a potent neuropeptide Y5 (NPY-5) receptor antagonist. |
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| DC66449 |
Anti-Trypanosoma cruzi agent-4
Featured
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Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection. |
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| DC66450 |
SPD-473 (citrate)
Featured
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SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior. |
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| DC60597 |
AZD0780
Featured
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AZD0780 is the first oral small molecule PCSK9 inhibitor for the treatment of hypercholesterolemia. |
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| DC66451 |
Teriparatide
Featured
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Teriparatide Free Base is a biologically active form of teriparatide, a recombinant human parathyroid hormone (PTH) analogue. It is used to treat osteoporosis in both men and postmenopausal women who are at high risk of fractures. Teriparatide works differently from most other osteoporosis medications, as it stimulates bone formation rather than just slowing bone loss. |
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