Cat. No. | Product name | CAS No. |
DC65174 | CPD1584-B3 HCl Featured | 2288710-66-5 |
DC65175 | CPD10000-A2 Featured | 2230840-10-3 |
DC60444 |
FX-909
Featured
FX-909(FX 909) is a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor with EC50 of 1 nM and shows >2000-fold selectivity for PPARG over PPARA/PPARD - acting through a mechanism that promotes a repressive conformation of PPARG. |
2924573-90-8 |
DC60445 |
BAY-2965501
Featured
BAY-2965501 is a first-in-class a diacylglycerol kinase zeta (DGKζ, lipid kinase) inhibitor with IC50 of 27 nM/35 nM (human/mouse) and shows >20-fold selectivity for DGKζ over other DGK isotypes. BAY-2965501 blocks DGKζ in T-cells to activate them |
2732902-08-6 |
DC60446 |
ABBV-319
Featured
ABBV-319 is a first-in-class glucocorticoid receptor modulator agonist ADC for B-cell malignancies |
|
DC60447 |
ARV-766
Featured
ARV-766 is an orally active and potent proteolysis targeting chimera (PROTAC) protein degrader. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations[1]. |
2750830-09-0 |
DC65209 |
M3913
Featured
M3913 is an antitumor compound. |
2379783-62-5 |
DC60449 |
TNG260
Featured
TNG260 is a CoREST-selective deacetylase inhibitor and shows 500-fold selectivity for the CoREST complex over the other HDAC1-containing complexes, NuRD and Sin3. |
2935964-98-8 |
DC60450 |
ZW251
Featured
ZW251 is an antibody drug conjugate (ADC) consisting of a topoisomerase l inhibitor payload conjugated to an antibody targeting Glypican-3(GPC3). |
|
DC60451 |
MRT-2539
Featured
MRT-2359 a potent, selective and orally bioavailable GSPT1-directed molecular glue degrader (MGD). |
2803881-11-8 |
DC60452 |
RMC-6291
Featured
RMC-6291 is a potent covalent inhibitor of KRASG12C(ON) that forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). RMC-6291 overcomes limitations of first-generation KRASG12C(OFF) inhibitors in preclinical models by directly targeting the active form of this important oncogenic driver. |
2641998-63-0 |
DC60453 |
dt-109
Featured
DT-109 is a glycine-based tripeptide (Gly-Gly-Leu) that lowers steatohepatitis and hepatic fibrosis via induction of fatty acid (FA) degradation and antioxidant defense through de novo glutathione (GSH) biosynthesis. |
|
DC72806 |
Camlipixant
Featured
Camlipixant (BLU-5937) a potent, selective, non-competitive and orally active P2X3 homotrimeric receptor antagonist with an IC50 of 25 nM against hP2X3 homotrimeric. Camlipixant shows potent anti-tussive effect and no taste alteration. Camlipixant can be used for the research of unexplained, refractory chronic cough. |
1621164-74-6 |
DC72808 |
UCM-1306
Featured
UCM1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD). |
2258608-78-3 |
DC72822 |
MS023 hydrochloride
Featured
MS023 hydrochloride is a potent, selective and cell-active inhibitor of human type I protein arginine methyltransferases (PRMT), with IC50 values of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively. |
2108631-19-0 |
DC72823 |
SU056
Featured
SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells. |
2376580-08-2 |
DC72826 |
Usp22i-S02
Featured
Usp22i-S02(USP22-IN-1, compound S02) is a potent inhibitor of ubiquitin specific peptidase 22 (USP22). It showed anticancer activity by suppressing Foxp3 expression in T-regulatory cells. |
309735-96-4 |
DC72829 |
Zuranolone
Featured
Zuranolone(SAGE-217, CS-2797) is an orally active and potent neuroactive steroid and positive allosteric modulator of the GABAA receptor, with EC50s of 296 nM for α1β2γ2 receptor. |
1632051-40-1 |
DC65176 |
LNP023
Featured
LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM). |
1644670-37-0 |
DC65177 |
8-Azaadenosine
Featured
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. 8-Azaadenosine blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells. |
10299-44-2 |
DC65178 |
AL-A12
Featured
AL-A12 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing AL-A12 and encapsulating minicircle DNA that encodes for GFP have been used to induce GFP expression in Huh7 cells. |
|
DC65179 |
Dlin-MC4-DMA
Featured
D-Lin-MC4-DMA(MC4) is a cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. |
1226909-66-5 |