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DM-1(Mertansine)

  Cat. No.:  DC8540   Featured
Chemical Structure
139504-50-0
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More than 5000 active chemicals with high quality for research!
Field of application
A cytotoxic agent used in antibody-drug conjugates
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 139504-50-0
Synonyms: Mertansine; DM 1; Maytansinoid DM 1; 139504-50-0; UNII-DDZ29HGH0E; DM1 Compound;
SMILES: SCCC(N(C(C(OC1CC(=O)N(C)C2=C(C(=CC(=C2)CC(C)=CC=CC(OC)C2(O)NC(OC(C2)C(C)C2OC12C)=O)OC)Cl)=O)C)C)=O
Formula: C35H48ClN3O10S
M.Wt: 738.29
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Mertansine (DM1) is a microtubulin inhibitor which binds at the tips of microtubules and suppresses the dynamicity of microtubules.. Mertansine is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery.
References: [1]. Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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DC8540 DM-1(Mertansine) A cytotoxic agent used in antibody-drug conjugates
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