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Cat. No.	Product Name	Field of Application
DC67420	AZD2389 Featured	AZD2389 represents a novel, orally bioavailable fibroblast activation protein (FAP) inhibitor with significant therapeutic potential.
DC67421	Enozertinib Featured	Enozertinib is a next-generation EGFR tyrosine kinase inhibitor demonstrating potent antineoplastic effects against EGFR-driven malignancies.
DC67422	Alixorexton( ALKS 2680) Featured	Alixorexton is a selective orexin-2 receptor (OX2R) agonist demonstrating significant metabolic modulation potential.
DC67423	BMS-986238 Featured	BMS-986238 represents an advanced macrocyclic peptide therapeutic that demonstrates potent and selective inhibition of PD-L1 immune checkpoint signaling.
DC67424	RP-1664 Featured	RP-1664 is a novel, orally bioavailable inhibitor that selectively targets polo-like kinase 4 (PLK4) with high potency.
DC67425	BMS-986458 Featured	BMS-986458 represents a breakthrough in targeted protein degradation as a first-in-class, orally available PROTAC® molecule that specifically degrades B-cell lymphoma 6 (BCL6).
DC67426	PRT3789 Featured	PRT3789 is a first-in-class proteolysis-targeting chimera (PROTAC) that selectively degrades SMARCA2 (BRM) while exhibiting minimal activity against its closely related paralog SMARCA4 (BRG1).
DC67427	FG-2101 Featured	FG-2101 represents a next-generation antibacterial agent as a potent, orally bioavailable non-hydroxamate inhibitor of LpxC – a key enzyme in Gram-negative bacterial lipopolysaccharide biosynthesis.
DC60819	MSD199 Featured	MSD199 is a potent, and selective Nav1.8 inhibitor with IC50 of 4.7 nM in Qube automated patch-clamp assay, >2000-fold selective over all other Nav isoforms.
DC60820	TAS3351 Featured	TAS3351 is a fourth-generation EGFR-TKI overcoming T790M and C797S-mediated resistance in NSCLC with common mutations. TAS3351 exhibites almost comparable inhibitory potency against cellular phosphorylation of EGFR harboring ex19del or L858R with or without C797S and/or T790M while sparing wild type EGFR activity.
DC60821	Lipid TOT-5 Featured	TOT-5, a tri-oleoyl-Tris ionizable lipid (pKa 6.2), enables splenic B cell-targeted mRNA delivery via 15% DSPC-incorporated LNPs. Its charge-neutral, hydrophobic surface minimizes hepatic ApoE uptake and enhances complement C3 adsorption, facilitating CD21/35-mediated uptake by marginal zone B cells. In vivo, intravenous 15%DSPC-LNPs showed 8-fold higher spleen-to-liver luciferase expression vs 3%DSPC, with anti-CD21/35 blocking 60% B cell uptake. Intramuscular administration induced robust OVA-specific IgG (10^5 titer) and CTL responses (3.5% tetramer+ CD8+ T cells) while reducing hepatotoxicity (ALT/AST levels ≤40 U/L vs SM-102-LNPs' 80-120 U/L). Cryo-ET confirmed stable lamellar structures (80-100 nm, ζ-potential -2 mV). This formulation achieves safe, ligand-free splenic targeting for mRNA vaccines.
DC67428	AMG-193 Featured	AMG 193 represents a novel class of targeted cancer therapeutics as an orally bioavailable, methylthioadenosine (MTA)-dependent PRMT5 inhibitor.
DC67429	(5-METHOXY-3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETIC ACID Featured
DC67430	1H-Benzimidazol-6-amine,2-(4-thiazolyl)- Featured
DC67431	TPBM Featured	TPBM represents a novel class of selective estrogen receptor α (ERα) modulators with a unique mechanism of action.
DC67432	Acriflavinium chloride Featured
DC67433	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Featured	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation.
DC67434	2-oxa-8-azabicyclo4.2.0octan-7-one Featured
DC67435	Fluphenazine Impurity 10 Featured
DC67436	Butanoic acid, 2-[(dimethylamino)methylene]-3-oxo-, ethyl ester, (2Z)- Featured
DC60822	JNJ-9676 Featured	JNJ-9676 is a small-molecule inhibitor targeting the coronavirus M protein. JNJ-9676 has double-digit nanomolar in vitro potency against sarbecoviruses including SARS-CoV, all tested variants of SARS-CoV-2, and bat and pangolin SARS-like coronaviruses.
DC60823	Ac-ATAD-AFC(Caspase-12 Substrate) Featured	Ac-ATAD-AFC(Caspase-12 Substrate) is a fluorogenic substrate for caspase-12.
DC60824	Ac-LETD-AFC Featured	Ac-LETD-AFC is a caspase-8 fluorogenic substrate. Ac-LETD-AFC can measure caspase-8 fluorogenic activity and can be used for the research of cancer cell apoptosis and oxidative stress metabolism.
DC67437	PI-2620 precursor Featured	PI-2620 precursor is the precursor of PI2620. 18F-PI-2620 is a PET tracer with high binding affinity for aggregated tau, a key pathologic feature of Alzheimer disease (AD) and other neurodegenerative disorders.
DC67438	6-(2,6-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine Featured
DC60825	11-10-8 Featured	11-10-8 is an ionizable cationic lipid (pKa = 6.22) that has been used in the generation of lipid nanoparticles (LNPs) for mRNA delivery in vivo.1 LNPs containing 11-10-8 and encapsulating mRNA encoding the Cas9 nuclease and small-guide RNA (sgRNA) targeting transthyretin (TTR), a thyroid hormone carrier protein, decrease serum levels of TTR in mice. LNPs containing 11-10-8 and encapsulating mRNA encoding human fibroblast growth factor 21 (hFGF21) increase serum levels of hFGF21, decrease body and liver weights, and reduce the liver steatosis score in a mouse model of obesity induced by a high-fat diet.
DC67440	SBFI-26 Featured	SBFI-26 (SBFI26) is a selective small-molecule antagonist of FABP5 and FABP7 that enhances endogenous anandamide signaling. It exhibits dose-dependent antinociceptive effects against mechanical hyperalgesia in vivo, along with notable anti-inflammatory activity. Additionally, it inhibits castration-resistant prostate cancer progression through competitive inhibition of oncogenic FABP5.
DC67441	Glutamate-cysteine ligase inhibitor EN25 Featured	EN25 is a covalent allosteric inhibitor of glutamate-cysteine ligase (GCL), selectively targeting cysteine residue C114 on the GCLM regulatory subunit with an IC50 of 16 μM.
DC67442	L-674573 Featured	L-674573 is a quinoline-based compound that specifically blocks 5-lipoxygenase cellular translocation, thereby inhibiting leukotriene biosynthesis.
DC67445	LB-102 Featured	LB102 demonstrates potent and selective inhibition of PP2A serine/threonine phosphatase activity, with half-maximal inhibitory concentration (IC50) of 400 nM.

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