| DC7780 |
ZM241385
Featured
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ZM 241385 is a Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. |
|
| DCAPI1517 |
Zotepine |
Zotepine is a SR-2A and D2DR inhibitor (Ki values are 0.69 and 2.3 nM respectively). Zotepine is also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). |
|
| DC9113 |
Ketanserin |
|
|
| DC9178 |
Ketanserin Tartrate |
|
|
| DC8755 |
WAY 100635 Hydrochloride
Featured
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|
|
| DC9187 |
Mosapride Citrate |
Mosapride citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist. |
|
| DC11140 |
MSX-3 hydrate |
|
|
| DC9284 |
SCH58261
Featured
|
SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively.
Cas: 160098-96-4 |
|
| DC9637 |
Desmopressin (Acetate)
Featured
|
Desmopressin(DDAVP) acetate is the synthetic analogue of the antidiuretic hormone arginine vasopressin. |
|
| DC10423 |
Motixafortide(BKT140)
Featured
|
Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ～1 nM. |
|
| DC9553 |
Carbetocin GMP grade
Featured
|
Carbetocin (Lonactene; Duratocin) is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth; an agonist at peripheral oxytocin receptors. |
|
| DC10079 |
CYM5541
Featured
|
CYM5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist (EC50 = 72-132 nM). |
|
| DC9552 |
Oxytocin (acetate)
Featured
|
Oxytocin (α-Hypophamine) acetate is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.
|
|
| DC8860 |
Vorapaxar
Featured
|
Vorapaxar (SCH 530348) is a potent and orally active thrombin receptor (PAR-1) antagonist with Ki of 8.1 nM. |
|
| DC8614 |
Rolapitant
Featured
|
Rolapitant (SCH619734) is a potent, selective and orally active neurokinin NK1 receptor antagonist with a Ki of 0.66 nM. |
|
| DC10475 |
Grapiprant
Featured
|
Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2) |
|
| DC26135 |
SKF 77434
Featured
|
Selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo. |
|
| DC8901 |
Azilsartan medoxomil
Featured
|
Azilsartan medoxomil(TAK 491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. |
|
| DC12355 |
Ceralifimod (ONO-4641) |
Ceralifimod is selective, high potent agonist for sphingosine 1-phosphate receptors 1 and 5, with EC50s of 27.3, 334 pM for human S1P receptor 1 and 5, respectively. |
|
| DC7694 |
BAF312 (Siponimod)
Featured
|
BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively |
|
| DC10561 |
GSK-2018682
Featured
|
GSK-2018682 is a sphingosine 1 phosphate receptor (S1PR)-1 agonist potentially for the treatment of multiple sclerosis. |
|
| DC7439 |
JTC-801 |
JTC-801 is a selective opioid receptor-like1 (ORL1) receptor antagonist with IC50 of 94 nM, weakly inhibits receptors δ, κ, and μ. |
|
| DC1076 |
Otenabant(CP945598.HCl)
Featured
|
CP-945598 HCl is a potent and selective cannabinoid type 1 receptor antagonist with Ki of 0.7 nM. |
|
| DC28031 |
AB928
Featured
|
AB928 is an orally bioavailable, selective dual adenosine receptor (A2aR/A2bR) antagonist with immunomodulatory activity. |
|
| DC28082 |
4-Hydroxypropranolol hydrochloride |
4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties. |
|
| DC28084 |
Hydroxybupropion
Featured
|
Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion . |
|
| DC28097 |
Desmethyl cariprazine |
Desmethyl cariprazine is an active metabolite of Cariprazine. Cariprazine, an antipsychotic drug candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM). |
|
| DC28099 |
Didesmethyl cariprazine |
Didesmethyl cariprazine is a metabolite of Cariprazine and acts as the predominant circulating active moiety. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a antipsychotic drug candidate that exhibits high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor. |
|
| DC28101 |
Dehydroaripiprazole |
Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
|
| DC28102 |
SR59230A
Featured
|
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively. |
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