Cat. No. | Product name | CAS No. |
DC12165 |
VU 0365114
Featured
VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. |
1208222-39-2 |
DC9497 |
VU0152100
Featured
VU0152100 is a potent and selective allosteric potentiator of M4 mAChR with an EC50 of 380 ± 93 nM. |
409351-28-6 |
DC9255 |
VU0357017
Featured
VU0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 ± 172 nM; pEC50 = 6.37 ± 0.15). |
1135242-13-5 |
DC11121 |
VU0418506
VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4). |
1330624-42-4 |
DC11112 |
VU0453595
VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1). |
1432436-13-9 |
DC11123 |
VU0467154
VU0467154 (VU 0467154) is a potent, selective M4 mAChR positive allosteric modulator with EC50 of 17.7 nM. |
1451993-15-9 |
DC11437 |
VU0652957
Featured
VU0652957 (VU2957, Valiglurax) is a potent, selective mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays; showes excellent pharmacokinetics across species (low CLps, %F > 35%), an acceptable CYP profile (>30 uM vs. 3A4, 2D6 and 2C9, 12.5 uM vs. 2C19 and 1.5 uM vs. 1A2), no CYP induction or timedependent inhibition and excellent metabolite coverage across species; also shows attractive predicted human PK parameters (CLps 5-9 mL/min/kg, Vds 1-2 L/kg and t1/2 2-4 hours). |
1976050-09-5 |
DC11120 |
VU6004256
VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM). |
2011034-33-4 |
DC10717 |
VU6005649
Featured
VU6005649 is a dual mGlu7/8 positive allosteric modulator with EC50s of 649 nM and 2.6 μM for mGlu7 and mGlu8, respectively. |
2137047-43-7 |
DC10136 |
VUF10460
Featured
VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. |
1028327-66-3 |
DC8851 |
VUF11207
Featured
VUF11207 is a highly potent CXCR7 agonist. VUF11207 induces recruitment of β-arrestin2 to the CXCR7 followed by internalization of the receptor. |
1378524-41-4 |
DC9668 |
WAY181187.HCl(WAY-181,187)
Featured
WAY-181187 is a potent and selective 5-HT6 receptor agonist. WAY-181187 possesses high affinity binding (2.2 and 4.8 nM, respectively) at the human 5-HT6 receptor and profile as full receptor agonists (WAY-181187: EC50=6.6 nM, Emax=93%). |
554403-49-5 |
DC2050 |
WIN-55212-2 mesylate
Featured
WIN 55212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with a Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. |
131543-23-2 |
DC7341 |
WZ 811
Featured
WZ811 is a novel small molecular and potency CXCR4 antagonist with EC50 of 0.3 nM. |
55778-02-4 |
DC9498 |
Xanomeline (oxalate)
Xanomeline(LY246708) is a selective M1 muscarinic receptor agonist. |
141064-23-5 |
DC11248 |
XL-001
XL-001 (XL001) is a novel specific CB2 inverse agonist with Ki of 0.5 nM. |
1426153-46-9 |
DC9007 |
Xylazine hydrochloride
Xylazine Hydrochloride is α2 class of adrenergic receptor agonist. |
23076-35-9 |
DC9932 |
YL-0919
Featured
YL-0919 is a novel synthetic compound with combined high affinity and selectivity for serotonin transporter and 5-HT1A receptors. |
1339058-04-6 |
DCAPI1015 |
Zafirlukast(Accolate)
Zafirlukast(Accolate) |
107753-78-6 |
DC9435 |
Zibotentan(ZD4054)
Featured
Zibotentan (ZD4054) is an orally administered, potent and specific ETA-receptor (endothelin A receptor) antagonist (IC50 = 21 nM). |
186497-07-4 |
DCAPI1039 |
Ziprasidone HCl
Ziprasidone HCl |
122883-93-6 |
DC7780 |
ZM241385
Featured
ZM 241385 is a Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. |
139180-30-6 |