TR-100 (TR100) is a specific anti-tropomyosin compound that disrupts the actin cytoskeleton via targeting of Tpm3.1-containing actin filaments.

TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4.

TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.

TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11.

TPA023B is a potent, α2/α3 subtype-selective GABAA receptor partial agonist with Ki of 2.0 and 1.8 nM, does not affect the functioning of the α1 subtype.

TPA023 is a potent, α2/α3 subtype-selective, and oral GABAA receptor agonist with Kd of 0.92, 1.05 and 0.58 nM for α1-, α2-, α3-, and α5-containing human receptors.

TP-472 is a novel BRD9/7 chemical probe that has excellent potency (BRD9 KD=33nM.

TP455 (TP-455) is a highly potent, selective A2A adenosine receptor inverse agonist with IC50 of 1.9 nM in cyclic AMP assays in hA2A CHO cells.

TP-353,TP353

TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30nM against CECR2 and 350nM against BPTF in an alphascreen assay, KD of 10nM for CECR2 and 120nM for BPTF in ITC assays.

TP-064N is a negative control chemical of TP-064, which is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM..

TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs.

TP-004 is a potent, selective METAP2 (Methionine aminopeptidase-2) inhibitor..

TP003 is a potent, functional selectivity for α3 subunit-containing GABAA receptor agonist with Ki of <1 nM for α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2, has no affinity for α4β3γ2 and α6β3γ2 (Ki>1 uM).

Tozadenant (SYN-115) is an adenosine A2A receptor antagonist.

Torsemide (Demadex)

Torezolid phosphate is a novel oxazolidinone for gram-positive infections, has an IC50 of 8.7 μM and 5.7 μM for monoamine oxidase (MAO)-A and MAO-B, respectively.

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.

Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allosteric modulator of GABA receptor-mediated currents.

Tomeglovir (BAY 384766) is a potent, highly selective, nonnucleoside inhibitor of cytomegalovirus (CMV) replication.

Toltrazuril sulfone is an antiprotozoal agent that acts upon Coccidia parasites.

Tolterodine L-Tartrate is a muscarinic receptor antagonist that is active at all mAChR M subtypes. This compound blocks the opening of ion channels by acetylcholine, which in turn leads to muscle relaxation by blocking neuronal signaling.

Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory agent (NSAID) with antioxidant and neuroprotective properties.

Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.

Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic drug.

Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 µM in HEK293 cells transfected with the human receptor).

Tofogliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).

Tofogliflozin (CSG-452) is a potent, highly selective SGLT2 inhibitor with Ki of 2.9, 14.9, and 6.4 nM against human, rat, and mouse SGLT2, respectively.

Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively.

TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ).