| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC73787 | JAB-3068 | JAB-3068 (JAB3068) is a potent, selective and orally bioavailable allosteric inhibitor of SHP2. |
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| DC73788 | K161 | K161 is a potent, pan-SHIP1/2 inhibitor with IC50 of 1.5- 6 uM and 6.5-13 uM, respectively. |
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| DC73789 | K306 | K306 is a specific, small molecule agonist of SH2-containing 5' inositol phosphatase 1 (SHIP1) with EC50 of 119 nM, 10-fold higher selectivity over SHIP2. |
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| DC73790 | NGD61181 | NGD61181 is a pyrazole-based SHIP2 inhibitor, has micromolar binding affinity and inhibitory activity, does not contain a phosphatase “warhead,” binds the active site of SHIP2. |
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| DC73791 | NSC49L | NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. |
|
| DC73792 | NSC74429 Featured | NSC74429 is a CNS-active, small molecule PHLPP inhibitor with IC50 of <5 uM, shows neuroprotective activity in primary rat cortical neurons in STS assay. |
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| DC73793 | SBI-221 | SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
|
| DC73794 | SBI-668 | SBI-668 is a selective inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM in isothermal CETSA assays, 7-fold selectivity over SHP2-WT (IC50=15 uM). |
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| DC73795 | Sanofi-14h | Sanofi-14h is a selective inhibitor of the AGC family kinase SGK3, blocks DMXAA-stimulated IRF3-promoter activity with IC50 of 1.73 uM, inhibits IFNβ production under STING stimulation. |
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| DC73796 | (R)-SW203668 | (R)-SW203668 (SCD inhibitor (R)-27) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=11 nM). |
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| DC73797 | TPT-004 | TPT-004 is a highly potent, selective tryptophan hydroxylase (TPH) with IC50 of 77 nM and 16 nM for TPH1 and TPH2, respectively. |
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| DC73798 | MLT-827 | MLT-827 is a potent and selective inhibitor of MALT1 paracaspase activity with IC50 of 5 nM. |
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| DC73799 | MLT-943 | MLT-943 is a potent and selective MALT1 protease inhibitor with IC50 of 40 nM in IL-2 reporter gene assay (Jurkat T cells), inhibits human PBMC IL-2 release with IC50 of 74 nM. |
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| DC73800 | ET516 | ET516 is a potent androgen receptor liquid-liquid phase separation (AR LLPS) inhibitor, specifically disrupts AR condensates, effectively suppresses AR transcriptional activity and inhibits the proliferation and tumor growth of prostate cancer cells expre |
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| DC73801 | Faznolutamide | Faznolutamide is a potent, selective androgen receptor (AR) antagonist. |
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| DC73802 | JJ-450 | JJ-450 is a novel analogue of IMTPPE and direct and specific inhibitor of androgen receptor (AR) transcriptional activity, blocks AR recruitment to androgen-responsive elements and suppresses AR target gene expression. |
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| DC73803 | M17-B15 | M17-B15 is a potent, specific small molecule inhibitor of androgen receptor (AR) targeting the dimer interface pocket (DIP), inhibits AR transcriptional inhibition with IC50 of 0.03 uM. |
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| DC73804 | MK-0773 Featured | MK-0773 is a selective androgen receptor modulators (SARMs) that binds to AR with an IC50 of 6.6 nM. |
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| DC73805 | SC428 | SC428 (SC-428) is a small molecule androgen receptor (AR) signaling inhibitor, directly binds to the AR N-terminal domain (NTD) and exhibits pan-AR inhibitory effect. |
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| DC73806 | UT-105 | UT-105 is a small-molecule, irreversible, selective androgen receptor (AR) degrader (SARD) and irreversible inhibitor, binds to AR N-terminal domain (NTD) and inhibits both the AR and AR splice variants (AR-SVs). |
|
| DC73807 | UT-215 | UT-215 (UT215) is a small-molecule selective androgen receptor (AR) irreversible covalent antagonist, covalently and selectively bind to C406 and C327 in the AF-1 region of AR. |
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| DC73808 | GDU-952 | GDU-952 is a novel small molecule aryl hydrocarbon receptor (AhR) agonist, activates and induces nuclear translocation of AhR. |
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| DC73809 | ITE Featured | A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro. |
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| DC73810 | D089 | D089 is a selective small molecule stabilizer of the MYC G4-quadruplex, not only inhibits MYC expression in myeloma cell lines, but also selectively induces G1 arrest in MYC-driven cancer cell lines containing the MYC-G4 sequence. |
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| DC73811 | Isopomiferin | Isopomiferin is a prenylated isoflavonoid, collapses the tumor checkpoint module (TCM) and suppresses both MYCN and TEAD4 in MYCN-amplified NBL cells. |
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| DC73812 | KSI-3716 | KSI-3716 is a small molecule c-MYC inhibitor that blocks c-MYC/MAX binding to target gene promoters, inhibits c-MYC mediated transcriptional activity at concentrations as low as 1 uM. |
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| DC73813 | MYRA-B | MYRA-B (NSC45641) is a small molecule that induces Myc-dependent apoptosis without affecting Myc transactivation or Myc/Max DNA binding. |
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| DC73814 | NSC13728 | NSC13728 is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization. |
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| DC73815 | NSC13728 hydrochloride | NSC13728 hydrochloride is a specific small molecule stabilizer of the Max homodimer inhibiting Myc function, also inhibits Myc-Max heterodimerization. |
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| DC73816 | VPC-70619 | VPC-70619 (VPC70619) is a selective small-molecule inhibitor of N-Myc transcription in NMYC transcription inhibition assays. |
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