| DC74087 |
MY-9B |
MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armad |
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| DC74088 |
Nalacin |
Nalacina is a small molecule that partially mimicks the effects of auxin and potent inhibitor of indole-3-acetic acid (IAA) conjugation mediated by group II GH3 (Gretchen Hagen 3) in vascular plants, inhibits Gretchen Hagen 3 (GH3) acyl acid amido synthet |
|
| DC74089 |
NCGC00108248 |
NCGC00108248 is small molecule inhibitor of Mir155 reporter, dose-dependently inhibits Mir155 reporter expression with EC50 of 2.2 uM. |
|
| DC74090 |
NCGC00378430
Featured
|
NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay. |
|
| DC74091 |
NCGC00507974 |
NCGC00507974 is a small molecule inhibitor of Mir155 reporter, dose-dependently inhibits Mir155 reporter expression with EC50 of 1.2 uM. |
|
| DC74092 |
NCI-41356 |
NCI-41356 is a small molecular inhibitor of αB-crystallin (CRYAB, HSPB5), significantly reducesthe interaction between CRYAB and VEGF165. |
|
| DC74093 |
NCP26
Featured
|
NCP26 is a potent, ATP-competitive prolyl-tRNA synthetase (ProRS, PRS) inhibitor, inhibits recombinant human ProRS in the presence of 100 μM proline with KD of 0.35 nM in TR-FRET assays. |
|
| DC74094 |
NERx 329 |
NERx 329 (RPAi 329, NERx329) is a novel potent, specific inhibitor of replication protein A (RPA), demonstrated potent RPA inhibitory activity in vitro, in vivo, and in cellular assays. |
|
| DC74095 |
Ninerafaxstat 3HCl
Featured
|
Ninerafaxstat 3HCl
(CV-8972) is a small molecule compound that promotes glucose oxidation, decreases fatty acid oxidation and improve overall mitochondrial respiration, inhibits the growth and proliferation of cancer cells. |
|
| DC74096 |
NIO-1 |
NIO-1 (Novel inhibitor of OCT1) is a novel small molecule inhibitor of Octamer transcription factor OCT1, inhibits OCT1 activation with IC50 of 0.11 uM. |
|
| DC74097 |
Nizubaglustat |
Nizubaglustat is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively. |
|
| DC74098 |
NOX-6-18
Featured
|
NOX-6-18 is a potent, selective GPR132 antagonist with IC50 of 17 nM. |
|
| DC74099 |
NOX-6-7 |
NOX-6-7 is a potent, selective GPR132 agonist with EC50 of 44 nM. |
|
| DC74100 |
NPD389 |
NPD389 is a potent, selective, fast-binding uncompetitive inhibitor of NADP+-dependent malic enzyme 2 (ME2) with IC50 of 4.63 uM, NPD389 is a mixed-type competitive inhibitor for the substrate L-malate and an uncompetitive inhibitor for the other substrat |
|
| DC74101 |
NSC 773097 |
NSC 773097 is a RITA analog that produces hyperselective cytotoxicity while maintaining antitumor efficacy (A498 cell IC50=130 nM). |
|
| DC74102 |
NSC33353 |
NSC33353 (NSC 33353) is a small molecule inhibitor with potent anti-tumor activity against TNBC cells, enhances TNBC sensitivity to doxorubicin. |
|
| DC74103 |
NUP-17d-52A |
NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM). |
|
| DC74104 |
NV848 |
NV848 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo. |
|
| DC74105 |
NV914 |
NV914 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo. |
|
| DC74106 |
NV930 |
NV930 is a small molecule inhibitor of tRNA-specific 2′-O-methyltransferase (FTSJ1), exerts readthrough activity in vitro and in vivo. |
|
| DC74107 |
NVS1.1 |
NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models. |
|
| DC74108 |
Opabactin |
Opabactin is an abscisic acid (ABA) mimic and agonist Arabidopsis subfamily III/II ABA receptors with nanomolar potency (7 nM). |
|
| DC74109 |
Ophiopogonin D |
Ophiopogonin-D (OP-D) is one of steroidal saponins isolated from the root of the Chinese medicinal plant Ophiopogon japonicas, possesses anti-inflammatory and anti-oxidant properties. |
|
| DC74110 |
Org 214444-0 |
Org 214444-0 is a highly potent, selective, allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 2.0/1.2 nM (human/rat FSHR) in cell-based assays. |
|
| DC74111 |
OSM-SMI-10B |
OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells. |
|
| DC74112 |
OV329 |
OV329 (OV 329) is a highly potent inactivator of gamma-aminobutyric acid aminotransferase (GABA-AT) with Ki of 9.69 uM. |
|
| DC74113 |
PAANIB-1 |
PAANIB-1 is a brain-penetrant PAAN/MIF nuclease inhibitor that prevents neurodegeneration that prevents neurodegeneration induced by α-syn PFF, AAV-α-syn overexpression, or MPTP intoxication in vivo. |
|
| DC74114 |
Panx-1 blocker 15b |
Panx-1 blocker 15b is a large-pore channel pannexin 1 (Panx1) inhibitor with IC50 of 0.8 uM. |
|
| DC74115 |
PAT1inh-A0030
Featured
|
PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A). |
|
| DC74116 |
PAT1inh-B01
Featured
|
PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM. |
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