| DC74870 |
NAN190 free base |
NAN-190 is a mixed antagonist and partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A. NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles. NAN-190 potentiates the impairment of retention produced by swim stress. NAN-190 is a possible antagonist for methamphetamine. |
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| DC74871 |
Mebeverine Acid |
Mebeverine acid is a metabolite of the antispasmodic agent mebeverine. |
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| DC74872 |
SKF89976A HCl |
SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo. |
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| DC74873 |
W-9 HCl |
W-9 is a Calmodulin antagonist |
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| DC74874 |
ABT-925 free base |
ABT-925, also known as A-37203, BSF-201640; DAT-201; Lu-201640; and A-437203, is a selective dopamine D3 receptor (DRD3) antagonist with an approximately 100-fold higher in vitro affinity for dopamine D₃ versus D₂ receptors. ABT-925 was tested in schizophrenia. ABT-925 is a selective dopamine D₃ receptor antagonist with an approximately 100-fold higher in vitro affinity for dopamine D₃ versus D₂ receptors. |
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| DC74875 |
Ensitrelvir |
Ensitrelvir, also known as S-217622, is an antiviral drug developed by Shionogi in partnership with Hokkaido University, which acts as an orally active 3C-like protease inhibitor for the treatment of COVID-19 infection. It is taken by mouth, and has been successfully tested against the recently emerged Omicron variant. It is the first orally active non-covalent, non-peptidic, SARS-CoV-2 3CL protease inhibitor (IC50=13 nM). It became the first Japanese domestic pill to treat COVID-19, third to be regulatorally approved in Japan; in February 2022. |
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| DC74876 |
Deuremidevir HBr |
Deuremidevir, also known as VV116, JT001, and mindeudesivir, is a chemically-modified version of the antiviral remdesivir with oral bioavailability and potent activity against SARS-CoV-2. Deuremidevir is a deuterated, tri-isobutyrate ester prodrug of the RDV parent nucleoside, and is rapidly metabolized into the parent nucleoside (116-N1) in the body. 116-N1 is intracellularly converted to the nucleoside triphosphate active form, which would interfere with the function of RNA-dependent RNA polymerase of SARS-CoV-2, thus exerting antiviral effects. Deuremidevir showed potent activity against a panel of SARS-CoV-2 variants (alpha, beta, delta, and omicron) and excellent therapeutic efficacy in the mice model. Note: the non-labeled analog is called GS621763 (Cat#465727). |
|
| DC74877 |
Propargylcholine bromide |
Propargylcholine bromide is an alkynyl derivative of choline that has a propargyl group in place of one methyl group. It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides. |
|
| DC74878 |
TMPH inhibitor |
TMPH is an inhibitor of CNS nicotinic receptor. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal α (i.e., α3 and α4) and β subunits (β2 and β4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (α1β1γδ) or α7 receptors. |
|
| DC74879 |
GW3965 HCl |
GW-3965 is a liver X receptor agonist. GW3965 represses the production of pro-inflammatory cytokines by murine mast cells. GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. GW3965 reduces tissue factor production and inflammatory responses in human islets in vitro. GW3965 dose-dependently regulates lps-mediated liver injury and modulates posttranscriptional TNF-alpha production and p38 mitogen-activated protein kinase activation in liver macrophages. |
|
| DC74880 |
BD1047 HBr |
BD1047 is a potent and selective Sigma-1 Receptor Antagonist. It has effects in animal studies suggestive of antipsychotic activity and may also be useful in the treatment of neuropathic pain. BD-1047 has >50-fold selectivity at σ1 over σ2 and also >100-fold selectivity over opiate, phencyclidine, muscarinic, dopamine, α1- & α2-adrenoceptor, 5-HT1, and 5-HT2. |
|
| DC74881 |
Bexotegrast free base |
Bexotegrast, also known as PLN-74809, is a small-molecule, dual selective inhibitor of αVβ1 / αVβ6 for idiopathic pulmonary fibrosis (IPF) and primary sclerosing cholangitis (PSC). These integrins cause upstream activation of TGF-β1 in actively fibrotic tissue. Inhibition of these integrins will block TGF-β1 activation, thereby preventing the growth of fibrotic tissue within the lung and bile ducts. |
|
| DC74882 |
PF-CBP1 free base |
PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons. |
|
| DC74883 |
Atosiban acetate |
Atosiban, also known as ORF 22164, RWJ 22164, is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Although initial studies suggested it could be used as a nasal spray and hence would not require hospital admission, it is not used in that form. It was developed by Ferring Pharmaceuticals in Sweden and first reported in the literature in 1985. Originally marketed by Ferring Pharmaceuticals, it is licensed in proprietary and generic forms for the delay of imminent pre-term birth in pregnant adult women. |
|
| DC74884 |
PFSM-B5 |
PFSM-B5, also known as DUN 00302. |
|
| DC74885 |
WAY-300716 |
WAY-300716 is a useful chemical reagent for laboratory study. |
|
| DC74886 |
WAY-604116 |
WAY-604116 is a 11-β-hydroxysteroid dehydrogenase inhibitor. |
|
| DC74887 |
FIPI HCl |
FIPI is a potent and selective phospholipase D inhibitor. FIPI attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. FIPI rapidly blocks in vivo PA production with subnanomolar potency. We were surprised to find that several biological processes blocked by 1-butanol are not affected by FIPI, suggesting the need for re-evaluation of proposed FIPI does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis, indicating potential utility for it as a therapeutic for autoimmunity and cancer metastasis. |
|
| DC74888 |
Tranylcypromine sulfate |
Tranylcypromine is a monoamine oxidase inhibitor (MAOI)—it is a nonselective and irreversible inhibitor of the enzyme monoamine oxidase (MAO). It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. |
|
| DC74889 |
DOPA lipid |
DOPA lipid, also known as 18:1 PA; 1,2-dioleoyl-sn-glycero-3-phosphate (sodium salt); PA(18:1(9Z)/18:1(9Z)); is a lipid compound. |
|
| DC74890 |
WYE-176182 |
WYE-176182 is an apical sodium-dependent bile salt transporter (SLC10A2) inhibitor |
|
| DC74891 |
WAY-348941 |
WAY-348941 is an immunosuppressive agent. |
|
| DC74892 |
WAY-638394 |
WAY-638394 is a laboratory reagent, which may be useful for treating bone deficit conditions. |
|
| DC74893 |
BMS-363131 |
BMS-363131 is very potent inhibitor of human tryptase with high selectivity versus other serine proteases, including trypsin. |
|
| DC74894 |
WAY-117885 |
WAY-117885 is a laboratory reagent, which may be used for altering the lifespan of a eukaryotic organism. |
|
| DC74895 |
Pitavastatin calcium |
Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. |
|
| DC74896 |
Benzhexol HCl |
Benzhexol, also known as Trihexyphenidyl, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades. |
|
| DC74897 |
Bemoradan |
Bemoradan, also known as WJ-22867, is a potent, long-acting orally active inodilator and cardiotonic agent. Bemoradan is a novel, potent positive inotropic agent, demonstrated biphasic inhibition of the fraction III enzyme from canine cardiac muscle. Bemoradan is well and rapidly absorbed after oral dosing, has linear pharmacokinetics and long elimination half-lives across species. |
|
| DC74898 |
Ertugliflozin |
Ertugliflozin, also known as also known as PF-04971729, is is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 0.927 nM for the human enzyme). clinical study showed that Ertugliflozin (1-25 mg/day) improved glycaemic control, body weight and blood pressure in patients with T2DM suboptimally controlled on metformin, and was well tolerated. |
|
| DC74899 |
Kaempferol 3-glucuronide |
Kaempferol 3-glucuronide inhibits the production of reactive oxygen species (ROS) induced by fMLP in isolated human neutrophils. |
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