Cat. No. | Product name | CAS No. |
DC22553 |
KIN-1408
A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus). |
1903800-11-2 |
DC11686 |
(R)-CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3).. |
1257861-18-9 |
DC11687 |
(S)-CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3).. |
1257861-17-8 |
DC11685 |
CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3).. |
1226686-36-7 |
DC22799 |
ML-162
Featured
A small-molecule probe that selectively kills cells induced to express mutant RAS. |
1035072-16-2 |
DC22800 |
ML-210
Featured
A small-molecule probe that selectively kills cells induced to express mutant RAS. |
1360705-96-9 |
DC21029 |
Fusicoccin-A
A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1. |
20108-30-9 |
DC22854 |
PhiKan-083
A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM. |
1050480-30-2 |
DC23009 |
Gue-1654
A small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R in both recombinant and human primary cells. |
397290-30-1 |
DC20886 |
CGP-049090
A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines. |
35082-49-6 |
DC11638 |
BCI(NSC 150117)
Featured
BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish. |
1245792-51-1 |
DC22392 |
BRD-4592
A small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB). |
2109805-80-1 |
DC21831 |
Tepilamide fumarate
A small-molecule, fumaric acid ester (FAE) compound that is a prodrug of methyl hydrogen fumarate (also known as monomethyl fumarate), for the treatment of relapsing-remitting multiple sclerosis and plaque psoriasis.. |
1208229-58-6 |
DC21244 |
LMP-420
A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells. |
473870-63-2 |
DC26093 |
PH-064
Featured
A sodium channel inhibitor.. |
892546-37-1 |
DC24093 |
PF-915275
Featured
PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki < 1 nM) with good preclinical pharmacokinetic properties.IC50 value: < 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 μM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2] |
857290-04-1 |
DC11774 |
YM-53403
A specific anti-respiratory syncytial virus (RSV) agent with EC50 of 0.2 uM in plaque reduction assays. |
851331-05-0 |
DC22642 |
Sibiriline
A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3. |
1346526-26-8 |
DC21394 |
NOFD
A specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM). |
856680-67-6 |
DC23022 |
PDZ1i
Featured
A specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII. |
2083618-79-3 |
DC23589 |
CGP 37157
Featured
A specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells. |
75450-34-9 |
DC22633 |
SB 203580 hydrochloride
A specific p38 MAPK inhibitor with IC50 of 0.6 uM. |
869185-85-3 |
DC22835 |
SCH 350581
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
306293-36-7 |
DC22830 |
SCH 350581 dihydrochloride
A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry.. |
372156-82-6 |
DC20361 |
Difopein
A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity. |
396834-58-5 |
DC22803 |
M-443
A specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl. |
1820684-31-8 |
DC11510 |
FR-900359
A specific, membrane-permeable inhibitor of Gq signaling. |
107530-18-7 |
DC20643 |
ADDA 5
A specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma). |
473268-46-1 |
DC23301 |
Bax activator compound 106
A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis. |
1638526-94-9 |
DC24150 |
Griseofulvin
A spirocyclic fungal natural product used in treatment of fungal dermatophytes.. |
126-07-8 |
DCAPI1583 |
liranaftate
A squalene epoxidase inhibitor that is used as an antifungal agent. |
88678-31-3 |
DC22669 |
ONO-1301
Featured
A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase. |
176391-41-6 |
DC26088 |
Stauprimide
A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription. |
154589-96-5 |
DC22385 |
Adrenosterone
A steroid hormone with a weak androgenic effect, and an intermediate/prohormone of 11-ketotestosterone.. |
382-45-6 |
DC23926 |
Fiacitabine
A synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent. |
69123-90-6 |
DC24191 |
Cyclophosphamide hydrate
Featured
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
6055-19-2 |
DC22562 |
OABK hydrochloride
A synthetic amino acid that fuctions as a small molecule switch for activation of protein function through the site-specific incorporation. |
1984862-48-7 |
DC22546 |
Antibiotic-5d
A synthetic antimicrobial compound that antibacterial activity in vitro against various Gram-positive and Gram-negative bacteria, fungi and yeast.. |
251349-54-9 |
DC23906 |
Butenafine hydrochloride
Featured
A synthetic benzylamine antifungal that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase. |
101827-46-7 |
DC20656 |
AM-2201
A synthetic cannabinoid that acts as a potent, nonselective full agonist for the cannabinoid receptor with EC50 of 38 and 58 nM for CB1 and CB2, respectively. |
335161-24-5 |
DC23209 |
HO-3867
Featured
A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
1172133-28-6 |
DC11517 |
Benzodrocortisone
A synthetic glucocorticoid corticosteroid.. |
28956-89-0 |
DC11525 |
Mocravimod
A synthetic immunosuppressant that functions as a S1P1 receptor agonist. |
509092-16-4 |
DC23705 |
Lenabasum
A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ. |
137945-48-3 |
DC22494 |
ST-2825
A synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner. |
894787-30-5 |
DC22357 |
Benfotiamine
A synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects. |
22457-89-2 |
DC22458 |
RX-055
A tailored WOBE437-derived diazirine-containing photoaffinity probe that irreversibly blocks membrane transport of both endocannabinoids. |
2108098-33-3 |
DC22474 |
Demeclocycline hydrochloride
A tetracycline antibiotic that acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria. |
64-73-3 |
DC23965 |
Clopidogrel thiolactone
Featured
A thienopyridine-class antiplatelet agent that works by irreversibly inhibiting P2Y12 receptor on platelets. |
1147350-75-1 |
DC7517 |
THIACETAZONE
Featured
A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the I |
104-06-3 |
DC25059 |
BMS-986001
A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM. |
634907-30-5 |
DC9633 |
Toll-like receptor modulator
A Toll-like receptor modulator. |
926927-42-6 |
DC24097 |
Ufenamate
A topical analgesic that possesses anti-inflammatory effect for treatment of skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis.. |
67330-25-0 |
DC22457 |
NAPQI
Featured
A toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of MIF. |
50700-49-7 |
DC24092 |
Posaconazole hydrate
Featured
A triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole.. |
1198769-38-8 |
DC21517 |
Mithramycin A
A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. |
18378-89-7 |
DC21638 |
SLV peptide
A tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas. |
189109-89-5 |
DC24136 |
Amitifadine hydrochloride
A triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively). |
410074-74-7 |
DC22736 |
Amitifadine
A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively. |
410074-73-6 |
DC21185 |
Cucurbitacin I
A triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM. |
2222-07-3 |
DC23062 |
RAMX3
A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM. |
1397708-94-9 |
DC22473 |
Loxapine
A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.. |
1977-10-2 |
DC22477 |
Loxapine succinate
A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors.. |
27833-64-3 |
DC8197 |
Tyrosine kinase inhibitor
Featured
A Tyrosine kinase inhibitor. |
1021950-26-4 |
DC22811 |
TX-1123
A tyrphostin AG17 analog that exihibits potent Src-K inhibitory activity with IC50 of 2.2 uM. |
157397-06-3 |
DC24189 |
Closantel sodium
A veterinary anthelmintic with known proton ionophore activities. |
61438-64-0 |
DC24190 |
Closantel
A veterinary anthelmintic with known proton ionophore activities. |
57808-65-8 |
DC23096 |
BCX-4430
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator. |
222631-44-9 |
DC25095 |
BCX4430 freebase
A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator. |
249503-25-1 |
DC22579 |
Retaspimycin hydrochloride
A water-soluble derivative of 17-AAG and HSP90 inhibitor. |
857402-63-2 |
DC22983 |
Minnelide
A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival. |
1254702-87-8 |
DC22868 |
Propofol
A widely used general anesthetic to induce and maintain anesthesia. |
2078-54-8 |
DC23233 |
AH 6809
Featured
A xanthone derivative that fuctions as an EP and DP receptor antagonist. |
33458-93-4 |
DC22878 |
LB-205
A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo. |
1113025-86-7 |
DC11491 |
A-1048400
A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively. |
1219624-62-0 |
DC9768 |
A1155463
Featured
A-1155463 is a highly potent and selective BCL-XL inhibitor. |
1235034-55-5 |
DC8475 |
A-1210477
Featured
A-1210477 is a potent and selective MCL-1 inhibitor. |
1668553-26-1 |
DC10920 |
A12B4C3
A12B4C3 (hPNKP inhibitor A12B4C3) is a specific, noncompetitive inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (hPNKP) with C50 of 60 nM, displays no inhibition of calcineurin and protein phosphatase-1 or APTX. |
1005129-80-5 |
DC9296 |
A-1331852
Featured
A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL. |
1430844-80-6 |
DC12702 |
A1874
Featured
A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells). |
2064292-12-0 |
DC10509 |
A-196
Featured
A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. |
|
DC7044 |
A-205804
A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively. |
251992-66-2 |
DC9574 |
A-317491 (sodium salt hydrate)
Featured
A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors. |
475205-49-3 |
DC11490 |
A-317567
A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM. |
371217-32-2 |
DC23659 |
A-357300
A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM. |
369358-07-6 |
DC7855 |
A-366
Featured
A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM). |
1527503-11-2 |
DC12659 |
A-381393
Featured
A-381393 is a potent and selective agonist of the dopamine D4 receptor. |
726174-00-1 |
DC10129 |
A395
Featured
A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7) |
2089148-72-9 |
DC20610 |
A-395N
A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM.. |
2096983-62-7 |
DC22277 |
A-420983
Featured
A-420983 is a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection. |
330789-03-2 |
DC20611 |
A4250
Featured
A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH.. |
501692-44-0 |
DC8406 |
A-438079 HCl
Featured
A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. |
899431-18-6 |
DC12317 |
A-484954
A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM. |
142557-61-7 |
DC7538 |
A66
Featured
A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms. |
1166227-08-2 |
DC5163 |
A-674563
Featured
A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively. |
552325-73-2 |
DC20612 |
A-68930 hydrochloride
A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM. |
130465-39-3 |
DC7351 |
A-740003
A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
861393-28-4 |
DC7045 |
A-769662
Featured
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
844499-71-4 |
DC11372 |
A-779
Featured
A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay). |
159432-28-7 |
DC7785 |
A-790742
A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1. |
854755-48-9 |
DC20613 |
A-800141
A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM). |
681245-85-2 |
DC2061 |
A-803467
Featured
A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM. |
944261-79-4 |
DC9954 |
A 804598
Featured
A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
1125758-85-1 |
DC7286 |
A83-01
Featured
A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). |
909910-43-6 |
DC20614 |
A-832234
A-832234 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 19 nM.. |
904679-91-0 |
DC23183 |
A-836339
A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively. |
959746-77-1 |
DC9516 |
A-867744
A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X. |
1000279-69-5 |
DC11304 |
A939572
Featured
A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. |
1032229-33-6 |
DC22721 |
A-943931 dihydrochloride
A-943931 dihydrochloride is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
1227675-50-4 |
DC22720 |
A-943931
A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively. |
1027330-97-7 |
DC7046 |
A-966492
Featured
A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
934162-61-5 |
DC20616 |
AA 41612
Featured
AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner. |
433690-62-1 |
DC23202 |
JNJ-16259685
aA highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM. |
409345-29-5 |
DC23277 |
AA-115
Featured
AA-115 (APG 115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM. |
1818393-16-6 |
DC21979 |
ATF6 agonist compound A147
Featured
ATF6 agonist compound A147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells.147 has broad antiviral activity against multiple DENV strains and serotypes and that the compound i |
393121-74-9 |
DC10165 |
AA26-9
Featured
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. |
1312782-34-5 |
DC20961 |
AA-861
AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM. |
80809-81-0 |
DC26090 |
AAD777
AAD777 (NVP-AAD777. |
300842-59-5 |
DC10922 |
AAE871
AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity.. |
289479-07-8 |
DC20618 |
AAI-101
Featured
AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases. |
1001404-83-6 |
DC12566 |
AAK1 inhibitor 1
AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE ((BMP-2 inducible kinase)) that potently targets the ATP-binding site (AAK1 Ki =9.1 nM, BIKE Ki= 17 nM). |
2247894-32-0 |
DC21862 |
AAK1 inhibitor 25A
AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1). |
|
DC12400 |
AAL(S)
AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A).. |
1823156-89-3 |
DC23864 |
AAL993
Featured
AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively. |
269390-77-4 |
DC10797 |
AB-423
Featured
AB-423 is the first-generation Hepatitis B Virus Capsid Assembly inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies. |
1572510-80-5 |
DC21981 |
CD73 inhibitor AB-680
Featured
AB680 (AB-680) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73), displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, a |
2105904-82-1 |
DC9029 |
Abacavir
Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. |
136470-78-5 |
DC8161 |
Xeglyze(Abametapir)
Featured
Abametapir is the active ingredient of Xeglyze Lotion. |
1762-34-1 |
DC11452 |
ABBV-744
Featured
ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer.BBV-744, a highly potent and selective inhibitor of the BD2 domain of BET family proteins with drug-like properties. In contrast to the broad range of cell growth inhibition induced by DbBi, the antiproliferative activity of ABBV-744 was largely, but not exclusively, restricted to cell lines of acute myeloid leukaemia and prostate cancer that expressed the full-length androgen receptor (AR). ABBV-744 retained robust activity in prostate cancer xenografts, and showed fewer platelet and gastrointestinal toxicities than the DbBi ABBV-07514.Analyses of RNA expression and chromatin immunoprecipitation followed by sequencing revealed that ABBV-744 displaced BRD4 from AR-containing super-enhancers and inhibited AR-dependent transcription, with less impact on global transcription compared with ABBV-075. These results underscore the potential value of selectively targeting the BD2 domain of BET family proteins for cancer therapy. |
2138861-99-9 |
DC11299 |
ABC 1183
Featured
ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modu |
1042735-18-1 |
DC5027 |
ABC294640(Opaganib)
Featured
ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. |
915385-81-8 |
DC10929 |
ABC99
ABC99 is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family. |
|
DC12444 |
ABD-1970
ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL). |
2010154-82-0 |
DC11925 |
ABD328
ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo. |
1055896-19-9 |
DC20620 |
ABD345
ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation. |
1055896-51-9 |
DC23586 |
Abeprazan
Abeprazan is an acid pump inhibitor.. |
1902954-60-2 |
DC2710 |
Abiraterone (CB-7598)
Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM. |
154229-19-3 |
DC24211 |
Abiraterone (D4A)
Featured
Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone. |
154229-21-7 |
DC20619 |
ABL127
Featured
ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM. |
1073529-41-5 |
DC20298 |
ABL-IN-29
ABL-IN-29 is a picomolar ABL kinase inhibitor with IC50 of 0.06/0.11 nM for wt ABL and ABL T315I respectively.. |
1430719-97-3 |
DC20299 |
ABMA
ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. |
332108-65-3 |
DC8667 |
AB-MECA
Featured
AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors. |
152918-26-8 |
DC21983 |
Abn-CBD
Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM). |
22972-55-0 |
DC11762 |
ABP-A3
ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes. |
|
DC20625 |
ABT-072
ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b). |
1132936-00-5 |
DC22258 |
ABT-080
ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM. |
189498-57-5 |
DC20626 |
ABT-089
ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM. |
161417-03-4 |
DC21984 |
ABT-100
ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase). |
450839-40-4 |
DC20628 |
ABT-102
ABT-102 is a potent, highly selective, orally active TRPV1 antagonist that inhibits agonist-evoked increases in intracellular Ca(2+) levels with IC50 of 5-7 nM. |
808756-71-0 |
DC20629 |
ABT-107
ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs. |
855291-54-2 |
DC2002 |
Venetoclax(ABT-199)
Featured
ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM. |
1257044-40-8 |
DC4127 |
ABT-263 (Navitoclax)
Featured
ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. |
923564-51-6 |
DC23537 |
ABT-288
ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively. |
948845-91-8 |
DC7352 |
ABT-333
Featured
ABT-333 is an NS5B non-nucleoside polymerase inhibitor. |
1132935-63-7 |
DC10049 |
Tebanicline(ABT-594)
Featured
ABT-594 represents a novel class of broad-spectrum analgesics whose primary mechanism of action is activation of the neuronal nicotinic acetylcholine receptors. |
198283-73-7 |
DC9706 |
ABT-639
Featured
ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM). |
1235560-28-7 |
DC10723 |
ABT-702
Featured
ABT-702 is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). |
1188890-28-9 |
DC9262 |
ABT-719
Featured
ABT-719 is a potent bacterial DNA gyrase inhibitor. |
162829-90-5 |
DC9261 |
ABT-719 HCl
Featured
ABT-719 is a potent bacterial DNA gyrase inhibitor. |
162763-53-3 |
DC1022 |
ABT-737
Featured
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. |
852808-04-9 |
DC7353 |
ABT-751(E 7010)
Featured
ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. |
141430-65-1 |
DC4231 |
Linifanib (ABT-869)
Featured
ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families. |
796967-16-3 |
DC20630 |
ABTL0812
ABTL0812 is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells. |
57818-44-7 |
DC11155 |
ABX-1431
Featured
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
1446817-84-0 |
DC11183 |
ABX-1431 hydrochloride
Featured
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
2043074-64-0 |
DC23182 |
ABX464
Featured
ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM. |
1258453-75-6 |
DC7698 |
AC 55541
Featured
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. |
916170-19-9 |
DC11508 |
AC1903
Featured
AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model. |
831234-13-0 |
DC10293 |
AC260584
AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6. |
560083-42-3 |
DC11149 |
AC261066
AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
870773-76-5 |
DC12577 |
AC-263093
Featured
AC-263093 (AC263093) is a potent, functionally selective neuropeptide FF receptor type 2 (NPFFR2) agonist with pKi of 6.9. |
849459-86-5 |
DC10117 |
AC264613
Featured
AC264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. |
1051487-82-1 |
DC20631 |
AC-265347
AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays. |
1253901-26-6 |
DC20300 |
AC-4-130
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
1834571-82-2 |
DC21863 |
AC5 inhibitor C90
AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes. |
|
DC12086 |
AC-55649
Featured
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. |
59662-49-6 |
DC7700 |
AC710
Featured
AC710, is a potent Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. |
1351522-04-7 |
DC12492 |
N-(p-Amylcinnamoyl) anthranilic Acid (ACA)
Featured
ACA is a cell permeable inhibitor of PLA2,reported to inhibit α-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion. |
110683-10-8 |
DC9917 |
Acacetin
Featured
Acacetin is an O-methylated flavone found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana),Betula pendula (silver birch),and in the fern Asplenium normale. |
480-44-4 |
DC7047 |
AICAR (Acadesine)
Featured
Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3. |
2627-69-2 |
DC9660 |
Acalabrutinib(ACP196)
Featured
Acalabrutinib (ACP-196) is a second-generation, selective, irreversible inhibitor of BTK. |
1420477-60-6 |
DC8760 |
Acalisib
Featured
Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. |
870281-34-8 |
DC22280 |
Acarbose
Featured
Acarbose is the first identified α-glucosidase inhibitor. |
56180-94-0 |
DC11458 |
Ac-DEVD-pNA(Caspase-3 Substrate)
Featured
Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. |
189684-50-2 |
DC11359 |
Caspase-3 Substrate
Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. |
958001-92-8 |
DC9986 |
Acebilustat(ZK322)
Featured
Acebilustat(ZK322) is a potent and selective leukotriene A4 hydrolase inhibitor. |
943764-99-6 |
DC10592 |
ASL 601(Acecainide)
Featured
Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. |
34118-92-8 |
DC10318 |
Acelarin
Featured
Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine. |
840506-29-8 |
DC9127 |
Acemetacin
Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor. |
53164-05-9 |
DC9900 |
Acetaminophen
Featured
Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. |
103-90-2 |
DCAPI1009 |
Acetanilide (Antifebrin)
Acetanilide (Antifebrin) |
103-84-4 |
DC8978 |
Acetazolamide
Acetazolamide is a potent carbonic anhydrase (CA) inhibitor; best-studied agent for the amelioration of acute mountain sickness (AMS). |
59-66-5 |
DC20115 |
Acetoacetic acid sodium salt
Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. |
623-58-5 |
DC10248 |
Acetohydroxamic acid
Acetohydroxamic acid is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease. |
546-88-3 |
DC20151 |
Acetosyringone
Featured
Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself. Acetosyri |
2478-38-8 |
DC12151 |
Acetyl Perisesaccharide C
Acetyl Perisesaccharide C is an oligosaccharide, which is isolated from the root barks of Periploca sepium. |
110764-09-5 |
DC9894 |
Acetylcholine iodide
Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. |
2260-50-6 |
DC10637 |
Acetylspiramycin (ASPM)
Acetylspiramycin (ASPM) is a macrolide antimicrobial agent. |
24916-51-6 |
DC21985 |
Ac-IEPD-CHO
Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis.. |
1628355-80-5 |
DC11350 |
Caspase-8 Chromogenic Substrate I
Ac-IETD-pNA is a substrate for caspase-8. |
219138-21-3 |