Home > Inhibitors & Agonists
Cat. No. Product name CAS No.
DC22553 KIN-1408

A small-molecule MAVS-dependent IRF3 agonist that shows antiviral activity against Flaviviridae, Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus) and Paramyxoviridae (RSVs, Nipah virus).

1903800-11-2
DC11686 (R)-CCX-777

A small-molecule partial agonist of CXCR7 (ACKR3)..

1257861-18-9
DC11687 (S)-CCX-777

A small-molecule partial agonist of CXCR7 (ACKR3)..

1257861-17-8
DC11685 CCX-777

A small-molecule partial agonist of CXCR7 (ACKR3)..

1226686-36-7
DC22799 ML-162 Featured

A small-molecule probe that selectively kills cells induced to express mutant RAS.

1035072-16-2
DC22800 ML-210 Featured

A small-molecule probe that selectively kills cells induced to express mutant RAS.

1360705-96-9
DC21029 Fusicoccin-A

A small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.

20108-30-9
DC22854 PhiKan-083

A small-molecule stabilizer of p53 mutant Y220C with Kd of 150 uM.

1050480-30-2
DC23009 Gue-1654

A small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R in both recombinant and human primary cells.

397290-30-1
DC20886 CGP-049090

A small-molecule that specifically inhibits the interaction of β-catenin/LEF1 transcriptional complex in colon carcinoma cell lines.

35082-49-6
DC11638 BCI(NSC 150117) Featured

BCI is A small-molecule, allosteric inhibitor of DUSP6 (dual-specificity phosphatase 6) with IC50 of 12.3 uM; also inhibits human DUSP1 with IC50 of 11.5 uM; suppresses the ERK-induced activation of Dusp6 and regulates heart size in zebrafish.

1245792-51-1
DC22392 BRD-4592

A small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB).

2109805-80-1
DC21831 Tepilamide fumarate

A small-molecule, fumaric acid ester (FAE) compound that is a prodrug of methyl hydrogen fumarate (also known as monomethyl fumarate), for the treatment of relapsing-remitting multiple sclerosis and plaque psoriasis..

1208229-58-6
DC21244 LMP-420

A small-molecule, orally active inhibitor of TNF-α that reduces replication of HIV-1 (IC50=300 nM) and Mycobacterium tuberculosis in human cells.

473870-63-2
DC26093 PH-064 Featured

A sodium channel inhibitor..

892546-37-1
DC24093 PF-915275 Featured

PF-915275 is a potent and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) (Ki < 1 nM) with good preclinical pharmacokinetic properties.IC50 value: < 1 nM (Ki)[2]Target: 11βHSD1in vitro: PF-915275 maintains potency in our cellular assay against human 11βHSD1 (HEK293, EC50 = 5 nM) and is selective against human 11βHSD2 (HEK293, 1.5% inhibition 10 μM). PF-915275 displays only weak affinity for the rodent choline transporter (Ki = 9.6 μM) and the hamster melatonin MT3 receptor (Ki = 9.6 μM) in the Cerep Bioprint screening panel. PF-915275 has good in vitro pharmacokinetic properties. In particular, PF-915275 is categorized as a low clearance compound (liver microsome assays) with high permeability (Caco2 assay). [2]in vivo: As a prelude to in vivo studies with PF-915275, the rat pharmacokinetic properties of this compound were determined. PF-915275 has an excellent pharmacokinetic profile characterized by low clearance, long half-life and good oral bioavailability. [2]

857290-04-1
DC11774 YM-53403

A specific anti-respiratory syncytial virus (RSV) agent with EC50 of 0.2 uM in plaque reduction assays.

851331-05-0
DC22642 Sibiriline

A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.

1346526-26-8
DC21394 NOFD

A specific HIF asparaginyl hydroxylase (FIH) inhibitor with Ki of 83 uM, but not HIF prolyl hydroxylase (>1 mM).

856680-67-6
DC23022 PDZ1i Featured

A specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII.

2083618-79-3
DC23589 CGP 37157 Featured

A specific inhibitor of mitochondrial Na(+)-Ca(2+) exchanger (mNCE) with IC50 of 1.5 uM in INS-1 cells.

75450-34-9
DC22633 SB 203580 hydrochloride

A specific p38 MAPK inhibitor with IC50 of 0.6 uM.

869185-85-3
DC22835 SCH 350581

A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry..

306293-36-7
DC22830 SCH 350581 dihydrochloride

A specific small molecule inhibitor of CCR5, inhibits HIV-1 entry..

372156-82-6
DC20361 Difopein

A specific, competitive inhibitor of 14-3-3/ligand interactions with high affinity.

396834-58-5
DC22803 M-443

A specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl.

1820684-31-8
DC11510 FR-900359

A specific, membrane-permeable inhibitor of Gq signaling.

107530-18-7
DC20643 ADDA 5

A specific, non-competitive, small molecule cytochrome c oxidase (CcO or complex IV) inhibitor with IC50 of 18.93 uM (CcO from human glioma).

473268-46-1
DC23301 Bax activator compound 106

A specific, small molecule Bax agonist that promotes Bax-dependent but not Bak-dependent apoptosis.

1638526-94-9
DC24150 Griseofulvin

A spirocyclic fungal natural product used in treatment of fungal dermatophytes..

126-07-8
DCAPI1583 liranaftate

A squalene epoxidase inhibitor that is used as an antifungal agent.

88678-31-3
DC22669 ONO-1301 Featured

A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.

176391-41-6
DC26088 Stauprimide

A staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.

154589-96-5
DC22385 Adrenosterone

A steroid hormone with a weak androgenic effect, and an intermediate/prohormone of 11-ketotestosterone..

382-45-6
DC23926 Fiacitabine

A synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent.

69123-90-6
DC24191 Cyclophosphamide hydrate Featured

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

6055-19-2
DC22562 OABK hydrochloride

A synthetic amino acid that fuctions as a small molecule switch for activation of protein function through the site-specific incorporation.

1984862-48-7
DC22546 Antibiotic-5d

A synthetic antimicrobial compound that antibacterial activity in vitro against various Gram-positive and Gram-negative bacteria, fungi and yeast..

251349-54-9
DC23906 Butenafine hydrochloride Featured

A synthetic benzylamine antifungal that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase.

101827-46-7
DC20656 AM-2201

A synthetic cannabinoid that acts as a potent, nonselective full agonist for the cannabinoid receptor with EC50 of 38 and 58 nM for CB1 and CB2, respectively.

335161-24-5
DC23209 HO-3867 Featured

A synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs.

1172133-28-6
DC11517 Benzodrocortisone

A synthetic glucocorticoid corticosteroid..

28956-89-0
DC11525 Mocravimod

A synthetic immunosuppressant that functions as a S1P1 receptor agonist.

509092-16-4
DC23705 Lenabasum

A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.

137945-48-3
DC22494 ST-2825

A synthetic peptido-mimetic compound that inhibits MyD88 dimerization in a TIR-dependent manner.

894787-30-5
DC22357 Benfotiamine

A synthetic S-acyl derivative of thiamine (vitamin B1) that possesses anti-inflammatory effects.

22457-89-2
DC22458 RX-055

A tailored WOBE437-derived diazirine-containing photoaffinity probe that irreversibly blocks membrane transport of both endocannabinoids.

2108098-33-3
DC22474 Demeclocycline hydrochloride

A tetracycline antibiotic that acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria.

64-73-3
DC23965 Clopidogrel thiolactone Featured

A thienopyridine-class antiplatelet agent that works by irreversibly inhibiting P2Y12 receptor on platelets.

1147350-75-1
DC7517 THIACETAZONE Featured

A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the I

104-06-3
DC25059 BMS-986001

A thymidine analogue nucleoside reverse transcriptase inhibitor (NRTI) that inhibits HIV-2 isolates from treatment-naive individuals with EC50 of 30-81 nM.

634907-30-5
DC9633 Toll-like receptor modulator

A Toll-like receptor modulator.

926927-42-6
DC24097 Ufenamate

A topical analgesic that possesses anti-inflammatory effect for treatment of skin diseases, such as acute and chronic eczema, contact dermatitis, diaper dermatitis, miliaria and atopic dermatitis..

67330-25-0
DC22457 NAPQI Featured

A toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of MIF.

50700-49-7
DC24092 Posaconazole hydrate Featured

A triazole antifungal agent that blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors, more potent at inhibiting 14α-demethylase than itraconazole..

1198769-38-8
DC21517 Mithramycin A

A tricyclic pentaglycosidic, antineoplastic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA.

18378-89-7
DC21638 SLV peptide

A tripeptide representing the Fas-C terminus that specifically blocks the interaction of Fap1 with Fas.

189109-89-5
DC24136 Amitifadine hydrochloride

A triple monoamine reuptake inhibitor that inhibits the reuptake of [3H]serotonin, [3H]norepinephrine, and [3H]dopamine in HEK 293 cells expressing the corresponding human recombinant transporters (IC50 values of 12, 23, and 96 nM, respectively).

410074-74-7
DC22736 Amitifadine

A triple monoamine reuptake inhibitor, inhibits the reuptake of 5-HT, norepinephrine and dopamine in HEK 293 cells with IC50 of 12, 23 and 96 nM, respectively.

410074-73-6
DC21185 Cucurbitacin I

A triterpenoid compound that potently and selectively inhibits JAK/STAT3 pathway, suppresses the levels of phosphotyrosine STAT3 in A549 cell with IC50 of 500 nM.

2222-07-3
DC23062 RAMX3

A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.

1397708-94-9
DC22473 Loxapine

A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors..

1977-10-2
DC22477 Loxapine succinate

A typical antipsychotic agent that displays an extremely strong binding affinity for dopamine D4 and serotonin 5-HT2 receptors..

27833-64-3
DC8197 Tyrosine kinase inhibitor Featured

A Tyrosine kinase inhibitor.

1021950-26-4
DC22811 TX-1123

A tyrphostin AG17 analog that exihibits potent Src-K inhibitory activity with IC50 of 2.2 uM.

157397-06-3
DC24189 Closantel sodium

A veterinary anthelmintic with known proton ionophore activities.

61438-64-0
DC24190 Closantel

A veterinary anthelmintic with known proton ionophore activities.

57808-65-8
DC23096 BCX-4430

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.

222631-44-9
DC25095 BCX4430 freebase

A viral RNA-dependent RNA polymerase (RdRp) inhibitor that acts as a non-obligate RNA chain terminator.

249503-25-1
DC22579 Retaspimycin hydrochloride

A water-soluble derivative of 17-AAG and HSP90 inhibitor.

857402-63-2
DC22983 Minnelide

A water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival.

1254702-87-8
DC22868 Propofol

A widely used general anesthetic to induce and maintain anesthesia.

2078-54-8
DC23233 AH 6809 Featured

A xanthone derivative that fuctions as an EP and DP receptor antagonist.

33458-93-4
DC22878 LB-205

A Zn2+-dependent pan-inhibitor of class I and class II HDACs with a long half-life (12h) in vivo.

1113025-86-7
DC11491 A-1048400

A-1048400(A 1048400) is a novel potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.

1219624-62-0
DC9768 A1155463 Featured

A-1155463 is a highly potent and selective BCL-XL inhibitor.

1235034-55-5
DC8475 A-1210477 Featured

A-1210477 is a potent and selective MCL-1 inhibitor.

1668553-26-1
DC10920 A12B4C3

A12B4C3 (hPNKP inhibitor A12B4C3) is a specific, noncompetitive inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase (hPNKP) with C50 of 60 nM, displays no inhibition of calcineurin and protein phosphatase-1 or APTX.

1005129-80-5
DC9296 A-1331852 Featured

A-1331852 is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL.

1430844-80-6
DC12702 A1874 Featured

A1874 (A-1874) is a nutlin-based and BRD4-degrading PROTAC with DC50 of 32 nM (induce BRD4 degradation in cells).

2064292-12-0
DC10509 A-196 Featured

A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines.

DC7044 A-205804

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

251992-66-2
DC9574 A-317491 (sodium salt hydrate) Featured

A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.

475205-49-3
DC11490 A-317567

A-317567 (A317567) is a novel potent acid sensing ion channel (ASIC) blocker with IC50 of 2-30 uM.

371217-32-2
DC23659 A-357300

A-357300 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 0.12 uM, does not inhibit MetAP1 or leucine aminopeptidases at 10 uM.

369358-07-6
DC7855 A-366 Featured

A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC50 = 3.3 nM).

1527503-11-2
DC12659 A-381393 Featured

A-381393 is a potent and selective agonist of the dopamine D4 receptor.

726174-00-1
DC10129 A395 Featured

A-395 potently inhibited the formation of H3K27me3 (via antagonizing EED in the trimeric PRC2 complex (EZH2:EED:SUZ12)) with IC50 = 34 ± 2 nM (Hill Slope = 0.7)

2089148-72-9
DC20610 A-395N

A-395N is the negative control compound of A-395, which is a potent, selective, and cellularly active PRC2 subunit EED inhibitor with Kd of 1.5 nM..

2096983-62-7
DC22277 A-420983 Featured

A-420983 is a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.

330789-03-2
DC20611 A4250 Featured

A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH..

501692-44-0
DC8406 A-438079 HCl Featured

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

899431-18-6
DC12317 A-484954

A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM.

142557-61-7
DC7538 A66 Featured

A66 is a potent and specific p110α inhibitor with IC50 of 32 nM, >100 fold selectivity for p110α over other class-I PI3K isoforms.

1166227-08-2
DC5163 A-674563 Featured

A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM. Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.

552325-73-2
DC20612 A-68930 hydrochloride

A-68930 is a potent, specific, orally bioavailable agonist of the D1 Dopamine receptor with EC50 of 2.5 nM.

130465-39-3
DC7351 A-740003

A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively).

861393-28-4
DC7045 A-769662 Featured

A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity.

844499-71-4
DC11372 A-779 Featured

A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay).

159432-28-7
DC7785 A-790742

A-790742 is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor, with 50% effective concentrations ranging from 2 to 7 nM against wild-type HIV-1.

854755-48-9
DC20613 A-800141

A-800141 is a potent, highly specific, orally bioavailable MetAP2 inhibitor with IC50 of 12 nM, shows no inhibition for MetAP1 (IC50>30 uM).

681245-85-2
DC2061 A-803467 Featured

A-803467 is a selective NaV1.8 channel blocker with IC50 of 8 nM.

944261-79-4
DC9954 A 804598 Featured

A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively.

1125758-85-1
DC7286 A83-01 Featured

A83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).

909910-43-6
DC20614 A-832234

A-832234 is a potent, selective, reversible MetAP2 inhibitor with IC50 of 19 nM..

904679-91-0
DC23183 A-836339

A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.

959746-77-1
DC9516 A-867744

A-867744 is a positive allosteric modulator of α7 nAChRs (IC50 values are 0.98 and 1.12 μM for human and rat α7 receptor ACh-evoked currents respectively, in X.

1000279-69-5
DC11304 A939572 Featured

A939572 is a potent, and orally bioavailable SCD1 inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.

1032229-33-6
DC22721 A-943931 dihydrochloride

A-943931 dihydrochloride is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.

1227675-50-4
DC22720 A-943931

A-943931 is a potent, selective antagonist of histamine H4 receptor (H4R) with binding pKi of 8.33 and 8.42 for hH4 and rH4, respectively.

1027330-97-7
DC7046 A-966492 Featured

A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.

934162-61-5
DC20616 AA 41612 Featured

AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner.

433690-62-1
DC23202 JNJ-16259685

aA highly potent, selective, non-competitive and centrally active mGluR1 antagonist with Ki of 0.34 nM.

409345-29-5
DC23277 AA-115 Featured

AA-115 (APG 115) is a potent and orally active MDM2 inhibitor with Ki <1 nM, potently inhibits SJSA-1 cell growth with IC50 of 60 nM.

1818393-16-6
DC21979 ATF6 agonist compound A147 Featured

ATF6 agonist compound A147 is a specific, small molecule agonist of transcription factor ATF6, activates ATF6 and influences differentiation of stem cells.147 has broad antiviral activity against multiple DENV strains and serotypes and that the compound i

393121-74-9
DC10165 AA26-9 Featured

AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.

1312782-34-5
DC20961 AA-861

AA-861 (Docebenone) is a potent, selective 5-Lipoxygenase (5-LO) inhibitor with IC50 of 0.8 uM.

80809-81-0
DC26090 AAD777

AAD777 (NVP-AAD777.

300842-59-5
DC10922 AAE871

AAE871 (AAE-871) is a potent type I kinase inhibitor of FLT3 with IC50 of 34 nM, potently inhibits proliferation of FLT3-ITD- and D835Y-expressing cells (IC50<10 nM) through selective inhibition of FLT3 kinase activity..

289479-07-8
DC20618 AAI-101 Featured

AAI-101 is a novel extended-spectrum β-lactamase inhibitor with activity against many β-lactamases, including some class A and class D carbapenemases.

1001404-83-6
DC12566 AAK1 inhibitor 1

AAK1 inhibitor 1 (SGC-AAK1-1) is a potent, selective inhibitor of AAK1 and BMP2K/BIKE ((BMP-2 inducible kinase)) that potently targets the ATP-binding site (AAK1 Ki =9.1 nM, BIKE Ki= 17 nM).

2247894-32-0
DC21862 AAK1 inhibitor 25A

AAK1 inhibitor 25A is a potent, selective inhibitor of AAK1 and the closely related kinase BMP2K with Ki of 8 nM (AAK1).

DC12400 AAL(S)

AAL(S) is the chiral deoxy analog of the FDA approved drug FTY720, has been shown to inhibit proliferation and apoptosis in several cancer cell lines by activating protein phosphatase 2A (PP2A)..

1823156-89-3
DC23864 AAL993 Featured

AAL993 (ZK260253) is a potent, orally active VEGFR inhibitor with IC50 of 130, 23 and 18 nM for VEGFR-1, 2 and 3, respectively.

269390-77-4
DC10797 AB-423 Featured

AB-423 is the first-generation Hepatitis B Virus Capsid Assembly inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies.

1572510-80-5
DC21981 CD73 inhibitor AB-680 Featured

AB680 (AB-680) is a highly potent, selective, reversible inhibitor of CD73 with Ki/IC50 of 4.9/70 pM (hCD73), displays > 10,000-fold selectivity against related ecto-nucleotidases (CD39, NTPDases 2/3/8) and a large panel of unrelated enzymes, receptors, a

2105904-82-1
DC9029 Abacavir

Abacavir is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.

136470-78-5
DC8161 Xeglyze(Abametapir) Featured

Abametapir is the active ingredient of Xeglyze Lotion.

1762-34-1
DC11452 ABBV-744 Featured

ABBV-744 is a BDII-selective BET bromodomain inhibitor that is being investigated to treat AML and metastic castration-resistant prostate cancer.BBV-744, a highly potent and selective inhibitor of the BD2 domain of BET family proteins with drug-like properties. In contrast to the broad range of cell growth inhibition induced by DbBi, the antiproliferative activity of ABBV-744 was largely, but not exclusively, restricted to cell lines of acute myeloid leukaemia and prostate cancer that expressed the full-length androgen receptor (AR). ABBV-744 retained robust activity in prostate cancer xenografts, and showed fewer platelet and gastrointestinal toxicities than the DbBi ABBV-07514.Analyses of RNA expression and chromatin immunoprecipitation followed by sequencing revealed that ABBV-744 displaced BRD4 from AR-containing super-enhancers and inhibited AR-dependent transcription, with less impact on global transcription compared with ABBV-075. These results underscore the potential value of selectively targeting the BD2 domain of BET family proteins for cancer therapy.

2138861-99-9
DC11299 ABC 1183 Featured

ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modu

1042735-18-1
DC5027 ABC294640(Opaganib) Featured

ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity.

915385-81-8
DC10929 ABC99

ABC99 is a potent, selective inhibitor of the Wnt-deacylating enzyme serine hydrolase NOTUM with IC50 of 13 nM, shows excellent selectivity across the serine hydrolase family.

DC12444 ABD-1970

ABD-1970 (ABD1970) is a highly potent, selective Monoacylglycerol lipase (MGLL) inhibitor with IC50 of 13 nM (human MGLL).

2010154-82-0
DC11925 ABD328

ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.

1055896-19-9
DC20620 ABD345

ABD345 is a small molecule inhibitor of RANKL signalling, inhibits TNF-induced NF-κB and MAPK activation and inflammation.

1055896-51-9
DC23586 Abeprazan

Abeprazan is an acid pump inhibitor..

1902954-60-2
DC2710 Abiraterone (CB-7598)

Abiraterone (CB-7598) is a potent CYP17 inhibitor with IC50 of 2 nM.

154229-19-3
DC24211 Abiraterone (D4A) Featured

Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone.

154229-21-7
DC20619 ABL127 Featured

ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM.

1073529-41-5
DC20298 ABL-IN-29

ABL-IN-29 is a picomolar ABL kinase inhibitor with IC50 of 0.06/0.11 nM for wt ABL and ABL T315I respectively..

1430719-97-3
DC20299 ABMA

ABMA is a novel broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite.

332108-65-3
DC8667 AB-MECA Featured

AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.

152918-26-8
DC21983 Abn-CBD

Abn-CBD (Abnormal Cannabidiol) is a selective agonist of GPR55 receptor with EC50 of 2.5 uM, shows no significant activity against CB1 and CB2 receptors (EC50>30 uM).

22972-55-0
DC11762 ABP-A3

ABP-A3(ABP A3) is an inhibitor of ubiquitin conjugation that targets ubiquitin and Nedd8 E1 enzymes.

DC20625 ABT-072

ABT-072 is a novel, orally bioavailable non-nucleoside HCV NS5B polymerase inhibitor with EC50 of 0.3 nM (GT1b).

1132936-00-5
DC22258 ABT-080

ABT-080 is a potent FLAP inhibitor that inhibits ionophore-stimulated LTB(4) formation with with IC50 of 20 nM.

189498-57-5
DC20626 ABT-089

ABT-089 (Pozanicline) is a potent, selective α4β2 nAChR agonist with Ki of 16 nM.

161417-03-4
DC21984 ABT-100

ABT-100 (ABT100) is a highly selective, potent, orally bioavailable inhibitor of farnesyltransferase (FTase).

450839-40-4
DC20628 ABT-102

ABT-102 is a potent, highly selective, orally active TRPV1 antagonist that inhibits agonist-evoked increases in intracellular Ca(2+) levels with IC50 of 5-7 nM.

808756-71-0
DC20629 ABT-107

ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs.

855291-54-2
DC2002 Venetoclax(ABT-199) Featured

ABT-199 is a Bcl-2-selective inhibitor with Ki < 0.010 nM.

1257044-40-8
DC4127 ABT-263 (Navitoclax) Featured

ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively.

923564-51-6
DC23537 ABT-288

ABT-288 is a potent, selective and competitive antagonist of H3 receptor with Ki of 1.9/8.2 nM for human/rat H3 respectively.

948845-91-8
DC7352 ABT-333 Featured

ABT-333 is an NS5B non-nucleoside polymerase inhibitor.

1132935-63-7
DC10049 Tebanicline(ABT-594) Featured

ABT-594 represents a novel class of broad-spectrum analgesics whose primary mechanism of action is activation of the neuronal nicotinic acetylcholine receptors.

198283-73-7
DC9706 ABT-639 Featured

ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM).

1235560-28-7
DC10723 ABT-702 Featured

ABT-702 is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase).

1188890-28-9
DC9262 ABT-719 Featured

ABT-719 is a potent bacterial DNA gyrase inhibitor.

162829-90-5
DC9261 ABT-719 HCl Featured

ABT-719 is a potent bacterial DNA gyrase inhibitor.

162763-53-3
DC1022 ABT-737 Featured

ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

852808-04-9
DC7353 ABT-751(E 7010) Featured

ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively.

141430-65-1
DC4231 Linifanib (ABT-869) Featured

ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families.

796967-16-3
DC20630 ABTL0812

ABTL0812 is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells.

57818-44-7
DC11155 ABX-1431 Featured

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).

1446817-84-0
DC11183 ABX-1431 hydrochloride Featured

ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL).

2043074-64-0
DC23182 ABX464 Featured

ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM.

1258453-75-6
DC7698 AC 55541 Featured

AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.

916170-19-9
DC11508 AC1903 Featured

AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model.

831234-13-0
DC10293 AC260584

AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6.

560083-42-3
DC11149 AC261066

AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3).

870773-76-5
DC12577 AC-263093 Featured

AC-263093 (AC263093) is a potent, functionally selective neuropeptide FF receptor type 2 (NPFFR2) agonist with pKi of 6.9.

849459-86-5
DC10117 AC264613 Featured

AC264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation.

1051487-82-1
DC20631 AC-265347

AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays.

1253901-26-6
DC20300 AC-4-130

AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3.

1834571-82-2
DC21863 AC5 inhibitor C90

AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes.

DC12086 AC-55649 Featured

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.

59662-49-6
DC7700 AC710 Featured

AC710, is a potent Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.

1351522-04-7
DC12492 N-(p-Amylcinnamoyl) anthranilic Acid (ACA) Featured

ACA is a cell permeable inhibitor of PLA2,reported to inhibit α-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion.

110683-10-8
DC9917 Acacetin Featured

Acacetin is an O-methylated flavone found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana),Betula pendula (silver birch),and in the fern Asplenium normale.

480-44-4
DC7047 AICAR (Acadesine) Featured

Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3.

2627-69-2
DC9660 Acalabrutinib(ACP196) Featured

Acalabrutinib (ACP-196) is a second-generation, selective, irreversible inhibitor of BTK.

1420477-60-6
DC8760 Acalisib Featured

Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM.

870281-34-8
DC22280 Acarbose Featured

Acarbose is the first identified α-glucosidase inhibitor.

56180-94-0
DC11458 Ac-DEVD-pNA(Caspase-3 Substrate) Featured

Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases.

189684-50-2
DC11359 Caspase-3 Substrate

Ac-DNLD-AMC is a fluorogenic caspase-3 substrate.

958001-92-8
DC9986 Acebilustat(ZK322) Featured

Acebilustat(ZK322) is a potent and selective leukotriene A4 hydrolase inhibitor.

943764-99-6
DC10592 ASL 601(Acecainide) Featured

Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide.

34118-92-8
DC10318 Acelarin Featured

Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

840506-29-8
DC9127 Acemetacin

Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.

53164-05-9
DC9900 Acetaminophen Featured

Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively.

103-90-2
DCAPI1009 Acetanilide (Antifebrin)

Acetanilide (Antifebrin)

103-84-4
DC8978 Acetazolamide

Acetazolamide is a potent carbonic anhydrase (CA) inhibitor; best-studied agent for the amelioration of acute mountain sickness (AMS).

59-66-5
DC20115 Acetoacetic acid sodium salt

Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium salt induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes.

623-58-5
DC10248 Acetohydroxamic acid

Acetohydroxamic acid is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.

546-88-3
DC20151 Acetosyringone Featured

Acetosyringone is a phenolic compound from wounded plant cells, enables virA gene which encodes a membrane-bound kinase to phosphorylate itself and activate the virG gene product, which stimulates the transcription of other vir genes and itself. Acetosyri

2478-38-8
DC12151 Acetyl Perisesaccharide C

Acetyl Perisesaccharide C is an oligosaccharide, which is isolated from the root barks of Periploca sepium.

110764-09-5
DC9894 Acetylcholine iodide

Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.

2260-50-6
DC10637 Acetylspiramycin (ASPM)

Acetylspiramycin (ASPM) is a macrolide antimicrobial agent.

24916-51-6
DC21985 Ac-IEPD-CHO

Ac-IEPD-CHO is a potent, reversible inhibitor of serine protease Granzyme B (GzmB) with Ki of 80 nM, also inhibits caspase-7 (Ki=550 nM) and induces apoptosis..

1628355-80-5
DC11350 Caspase-8 Chromogenic Substrate I

Ac-IETD-pNA is a substrate for caspase-8.

219138-21-3
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