Cat. No. | Product name | CAS No. |
DC10564 |
BAR 502
Featured
BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively. |
1612191-86-2 |
DC20317 |
Barbadin
Barbadin is a small molecule that selectively inhibits the β-arrestin/β2-adaptin interaction (IC50=19.1/15.6 uM for β-arrestin1/2) without effect on the formation of receptor/β-arrestin complexes. |
356568-70-2 |
DC4135 |
Bardoxolone methyl
Featured
Bardoxolone methyl (also known as “RTA 402” and “CDDO-methyl ester”) is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. |
218600-53-4 |
DC5064 |
Baricitinib (INCB28050, LY3009104)
Featured
Baricitinib is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2,showed potent activity against COVID-19(SARS-COV-2). |
1187594-09-7 |
DC8258 |
Baricitinib phosphate
Featured
Baricitinib phosphate(INCB 028050; LY 3009104) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2,showed potent activity against COVID-19(SARS-COV-2). |
1187595-84-1 |
DC9935 |
Basmisanil(RG1662)
Featured
Basmisanil is a highly selective inverse agonist/negative allosteric modulator of α5 subunit-containing GABAA receptors which is under development by Roche for the treatment of cognitive impairment associated with Down syndrome. |
1159600-41-5 |
DC10021 |
Batefenterol
Featured
Batefenterol(GSK961081,TD-5959)is a Muscarinic Antagonist and β2-Agonist possessing both muscarinic antagonist (MA) and β2-adrenoceptor agonist (BA) properties (MABA). |
743461-65-6 |
DC8133 |
Batimastat(BB-94)
Featured
Batimastat was used to study the role of MMP in proteolytic release of EGF in human follicular thyroid carcinoma cell line FTC-133. |
130370-60-4 |
DC12663 |
Bax channel blocker(BAI-1)
Featured
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity. |
335165-68-9 |
DC23719 |
BAY 1024767
BAY 1024767 (BAY1024767) is a higly potent antagonist of androgen receptor (AR) wild-type (IC50=46 nM) and mutant forms located in the AR ligand-binding domain (LBD). |
1273068-71-5 |
DC9939 |
BAY 1082439
BAY 1082439 is a highly selective and balanced PI3Kα/β inhibitor demonstrated potent activity in tumors with activated PI3Kα and loss-of-function of PTEN. |
1375469-38-7 |
DC20750 |
BAY 1143269
BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP. |
|
DC10376 |
BAY-1143572
BAY 1143572 is a highly selective, potent and orally available inhibitor of PTEFb/CDK9; inhibits the proliferation of AML cell lines with a median IC50 of 385 nM. |
1414943-88-6 |
DC7869 |
BAY11-7082
Featured
BAY 11-7082 is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM. Also inhibiting components of the ubiquitin system. |
19542-67-7 |
DC8038 |
Bay 11-7085
Featured
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with an IC50 value of 10 μM. |
196309-76-9 |
DC23386 |
BAY 1238097
BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay. |
1564268-08-1 |
DC20589 |
BAY 1251152
Featured
BAY 1251152 (VIP152 ) is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM, displays> 50-fold selectivity against other CDKs. |
1610358-56-9 |
DC23745 |
BAY-2402234
Featured
BAY 2402234 (BAY2402234) is a novel potent, selective, orally bioavailable DHODH inhibitor with IC50 of 1.2 nM (human full-length DHODH). |
2225819-06-5 |
DC7782 |
BAY 41-2272
Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.. For the detailed information of BAY 41-2272, the solubility of BAY 41-2272 in water, the solubility of BAY 41-2272 in DMSO, the solubility of BAY 41-2272 in PBS buffer, the animal experiment (test) of BAY 41-2272, the cell expriment (test) of BAY 41-2272, the in vivo, in vitro and clinical trial test of BAY 41-2272, the EC50, IC50,and affinity,of BAY 41-2272, Please contact DC Chemicals. |
256376-24-6 |
DC10294 |
Bay 41-4109
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
298708-81-3 |
DC10291 |
Bay 41-4109 less active enantiomer
Bay 41-4109 less active enantiomer shows less activity than Bay 41-4109. BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
476617-51-3 |
DC10085 |
Bay 41-4109 (racemate)
Featured
BAY 41-4109 racemate is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM. |
298708-79-9 |
DC20747 |
BAY 41-8543
BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM). |
256498-66-5 |
DC7323 |
Pritelivir(BAY-57-1293)
Featured
BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex. |
348086-71-5 |
DC4113 |
Cinaciguat (BAY 58-2667)
Featured
BAY 58-2667 is a nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Displays potent cardiovascular effects. |
329773-35-5 |
DC9783 |
Bay 59-3074
Featured
Bay 59-3074 is a novel CB1/CB2 receptor partial agonist (Ki values are 48.3 and 45.5 nM at human CB1 and CB2 receptors respectively). |
406205-74-1 |
DC20748 |
BAY 60-2770
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM. |
1027642-43-8 |
DC23438 |
BAY 60-6583
BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR). |
910487-58-0 |
DC9578 |
Bay 60-7550
Featured
Bay 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human); 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5, PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A. |
439083-90-6 |
DC9632 |
BAY 61-3606 (dihydrochloride)
Featured
BAY 61-3606 2Hcl is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
648903-57-5 |
DC10660 |
BAY 61-3606 free base
Featured
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
732983-37-8 |
DC26066 |
BAY 61-3606 hydrochloride
Featured
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. |
1615197-10-8 |
DC9591 |
BAY 80-6946(Copanlisib)
Featured
BAY 80-6946(Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. |
1032568-63-0 |
DC11859 |
BAY85-8501
BAY 85-8501 (BAY85-8501) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 65 pM. |
1161921-82-9 |
DC7996 |
BAY 87-2243
Featured
BAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced HIF-1 activation. |
1227158-85-1 |
DC23559 |
Bay K-8644
Featured
Bay K-8644 is a potent L-type calcium channels (LTCCs) activator with EC50 of 17.3 nM, has positive inotropic, vasoconstrictive and behavioral effects in vivo. |
71145-03-4 |
DC10408 |
BAY1125976
Featured
BAY1125976 is a selective allosteric Akt1/2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. |
1402608-02-9 |
DC9679 |
BAY1217389
Featured
BAY1217389 is an orally bioavailable, selective inhibitor of the serine/threonine kinase monopolar spindle 1 (Mps1, TTK), with potential antineoplastic activity. |
1554458-53-5 |
DC22013 |
BAY-1316957
Featured
BAY-1316957 (BAY 1316957) is a highly potent, selective, orally available human prostaglandin E2 receptor subtype 4 (hEP4-R) antagonist with IC50 of 15.3 nM. |
1613264-40-6 |
DC11719 |
BAY-1436032
BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively. |
1803274-65-8 |
DC20751 |
BAY-1816032
Featured
BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases. |
1891087-61-8 |
DC10526 |
BAY-1895344 HCl(Elimusertib)
Featured
BAY-1895344 is a potent and selective ATM inhibitor. BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride. |
1876467-74-1 |
DC26020 |
BAY2335218(BAY-218)
Featured
BAY2335218(BAY-218) is the first-in-class AhR antagonist for overcoming tumor-mediated immunosuppression. |
2162982-11-6 |
DC23816 |
BAY-293 racemate
BAY-293 racemate (BAY293 racemate) is a potent SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 50 nM, the R-enantiomer (BAY-293) is the active form with IC50 of 21 nM, while the BAY-293 is less active (IC50=2,340 nM).. |
2244904-14-9 |
DC12029 |
BAY-299
Featured
BAY-299 is a potent and selective inhibitor of the bromodomain and PHD finger-containing (BRPF) family protein BRD1 (IC50 = 6 nM). |
2080306-23-4 |
DC11006 |
BAY-320
BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM. |
1445830-50-1 |
DC10978 |
BAY-3827
Featured
BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK as tool compound to evaluate the therapeutic potential of AMPK inhibition in MYC-dependent tumors; strongly inhibits Acetyl-CoA carboxylase (ACC) phosphorylation in COLO 320DM and IMR-32 cells, but fails to inhibit the proliferation of cells with dysregulated c-MYC or N-MYC. |
2377576-35-5 |
DC22015 |
BAY-386
BAY-386 (BAY386) is a potent, specific and reversible PAR-1 antagonist with IC50 of 10 nM (HEK cell) and binding IC50 of 56 nM, without affinity for PAR-4 (IC50>10 uM). |
1256941-06-6 |
DC11007 |
BAY-524
BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM. |
1445830-39-6 |
DC26010 |
BAY-545
Featured
BAY-545 is a novel, potent and selective antagonist of A2B adenosine receptor with an IC50 of 59 nM. BAY-545 also exhibits IC50s of 66, 400, 280 nM for human, mouse, rat A2Badenosine receptor in cells, respectively. |
1699717-32-2 |
DC12653 |
BAY-598
Featured
BAY-598 is a selective inhibitor of SMYD2. |
1906919-67-2 |
DC12088 |
BAY-678 racemate
BAY-678 racemate is a chemical probe candidate for Human Neutrophil Elastase (HNE). |
675103-35-2 |
DC20749 |
BAY-707
BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM. |
2109805-96-9 |
DC22016 |
BAY-7598
BAY-7598 (BAY7598) is a potent, selective MMP12 inhibitor.. |
1816257-74-5 |
DC11218 |
BAY-8002
Featured
BAY-8002 is a novel potent, selective, orally available monocarboxylate transporter 1 (MCT1) inhibitor (Kd=7.9 nM). |
724440-27-1 |
DC22017 |
BAY-826
BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM). |
1448316-08-2 |
DC11505 |
BAY-850
Featured
BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay. |
2099142-76-2 |
DC10107 |
BAY-876
Featured
BAY-876 is the first highly selective GLUT1 inhibitor with IC50 of 0.002 uM. show good metabolic stability in vitro and high oral bioavailability in vivo. |
1799753-84-6 |
DC11915 |
BAY-958
BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1. |
1335490-39-5 |
DC10057 |
Bayer-18
Featured
Bayer-18 is a selective TYK2 inhibitor, with an IC50 of 18.7nM on TYK2 as measured by TYK2 HTRF assays. |
1251752-12-1 |
DC7854 |
BAZ2-ICR
BAZ2-ICR is a selective BAZ2 bromodomain inhibitor (Kd values are 109 and 170 nM for BAZ2A and BAZ2B respectively). |
1665195-94-7 |
DC7372 |
Bazedoxifene-Acetate
Featured
Bazedoxifene acetate (TSE 424; WAY-TES 424), a novel selective estrogen receptor modulator (SERM), has been developed to have favorable effects on bone and the lipid profile while minimizing stimulation of uterine or breast tissues. |
198481-33-3 |
DC8922 |
Bazedoxifene
Featured
Bazedoxifene is a selective estrogen receptor modulator (SERM) currently in development for osteoporosis prevention and treatment. |
198481-32-2 |
DC12280 |
BB-Cl-Amidine
BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. |
1802637-39-3 |
DC10058 |
BBT594
BBT594 (NVP-BBT594), is potent and selective inhibitor of RET and JAK2. |
882405-89-2 |
DC20754 |
BC-1215
Featured
BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL. |
1507370-20-8 |
DC20755 |
BC-1485
BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination. |
2035085-19-7 |
DC21401 |
BC-21
BC-21 (NSC 109268) is a novel small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 6.55 uM. |
691005-38-6 |
DC20757 |
BC-23
BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM. |
6298-15-3 |
DC10885 |
BCI-121
Featured
BCI-121 is a SMYD3 inhibitor that impairs the proliferation of cancer cell. |
432529-82-3 |
DC20758 |
BCI-137
BCI-137 is a chemical compound able to compete with Argonaute 2 miRNAs binding, binds to Ago2 with Kd of 126 uM. |
112170-24-8 |
DC12446 |
BCL6 inhibitor 14
BCL6 inhibitor 14 is a potent BCL-6 inhibitor with FRET IC50 of 63 nM.. |
|
DC12447 |
BCL6 PROTAC 15
BCL6 PROTAC 15 is a novel B-cell lymphoma 6 (BCL6) PROTAC, significantly degrade BCL6 in a number of DLBCL cell lines, but neither BCL6 inhibition nor degradation selectively induces marked phenotypic response. |
|
DC20760 |
BCL6-IN-8
BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface. |
2204272-40-0 |
DC20761 |
BCM-599
BCM-599 is an efficient HBV capsid assembly inhibitor with in vitro IC50 of 13 uM, shows synergistic inhibitory effects on decreasing viral concentration combined with lamivudine in vivo.. |
1820763-99-2 |
DC9826 |
BCTC
Featured
BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. |
393514-24-4 |
DC23980 |
BCX-1470
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM). |
217099-43-9 |
DC8313 |
BD1047.2HBr
Featured
BD 1047 dihydrobromide is a selective antagonist of σ receptors. |
138356-21-5 |
DC23499 |
BD-1047
Featured
BD-1047 is a potent, selecitve Sigma 1 receptor (σ1) antagonist with Ki of 0.93 nM. |
138356-20-4 |
DC10280 |
BD1063 dhydrochloride
Featured
BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. |
206996-13-6 |
DC21101 |
BDCRB
Featured
BDCRB (GW 275175) is a potent and selective inhibitor of human CMV replication by blocking the processing and maturation of viral DNA.. |
142356-43-2 |
DC10860 |
BDP5290
Featured
BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. |
1817698-21-7 |
DC20763 |
BDP8900
BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2. |
2226507-05-5 |
DC20764 |
BDP9066
BDP9066 (BDP-9066) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM, >100-fold selectivity over related ROCK1 or ROCK2. |
2226507-04-4 |
DC12596 |
BDP-NAC
BDP-NAC is a novel persulfide donor that shows selectivity towards H2 O2 over other potential oxidative or nucleophilic triggers, resulting in the sustained release of the persulfide of N-acetyl cysteine (NAC). |
2230306-52-0 |
DC20765 |
BDT001
Featured
BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM. |
823837-22-5 |
DC20319 |
Beauvericin
Beauvericin is a cyclic hexadepsipeptide with antibiotic and insecticidal effects, shows activity against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals.. |
26048-05-5 |
DC9718 |
BEBT-908(CUDC-908)
Featured
BEBT-908(CUDC-908)is a novel PI3K/HDAC inhibitor. |
1235449-52-1 |
DC9964 |
BEC hydrochloride
Featured
BEC is a boronic acid-based arginine analog that acts as a slow-binding, competitive transition state inhibitor of arginase I and II (Ki = 310 nM for human recombinant type II arginase, pH 7.5). |
222638-67-7 |
DC20668 |
Becampanel
Becampanel (AMP 397) potent, competitive antagonist of the AMPA receptor (AMPAR) with IC50 of 11 nM. |
188696-80-2 |
DC9172 |
Beclomethasone Dipropionate
Beclometasone dipropionate is a potent glucocorticoid agonist; it is a prodrug of the free form, beclometasone. |
5534-09-8 |
DC8809 |
Bedaquiline fumarate
Featured
Bedaquiline fumarate(TMC207; R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis. |
845533-86-0 |
DC21007 |
Befiradol
Featured
Befiradol (F13640, NLX 112) is a highly potent, selective 5-HT1A receptor agonist with Ki of 2.7 nM. |
208110-64-9 |
DC12290 |
Befiradol hydrochloride (F 13640 hydrochloride)
Befiradol hydrochloride is a selective 5-HT1A receptor agonist. |
|
DC20030 |
Begacestat (GSI-953)
Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease. |
769169-27-9 |
DC7082 |
Belinostat (PXD101)
Featured
Belinostat (PXD101) is a novel pan-HDAC inhibitor with IC50 of 27 nM, with activity demonstrated in cisplatin-resistant tumors. |
414864-00-9 |
DC10448 |
Belizatinib(TSR-011)
Featured
Belizatinib(TSR-011) is an orally available inhibitor of both the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the tropomyosin-related kinases (TRK) TRKA, TRKB, and TRKC, with potential antineoplastic activity. |
1357920-84-3 |
DC8160 |
ZGN-440(Beloranib)
Beloranib is being studied as a first-in-class obesity therapy that demonstrates a unique mechanism of action through methionine aminopeptidase 2 (MetAP2 ) inhibition. |
251111-30-5 |
DC11470 |
Belotecan hydrochloride(CKD-602)
Featured
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative. |
213819-48-8 |
DC12278 |
Belvarafenib
Featured
Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. |
1446113-23-0 |
DC20135 |
Bemesetron (MDL 72222)
Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect. |
40796-97-2 |
DC9152 |
Benazepril Hydrochloride
Benazepril hydrochloride, an angiotensin converting enzyme inhibitor, which is a medication used to treat high blood pressure. |
86541-74-4 |
DC6908 |
Bendamustine HCL (SDX-105, Cytostasane)
Featured
Bendamustine HCL (Ribomustin, Treanda, SDX-105) is a DNA-damaging agent with IC50 of 50 μM. |
3543-75-7 |
DC12299 |
Benfluralin
Benfluralin is a kind of herbicide and an agrochemical which can be used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops. |
1861-40-1 |
DCAPI1606 |
Benserazide
Benserazide is a peripherally-acting aromatic L-amino acid decarboxylase (AAAD) or DOPA decarboxylase inhibitor. |
14919-77-8 |
DC10701 |
Benzamide (NSC 404988)
Featured
Benzamide (NSC 404988) is a bioactive compound. |
7461-38-3 |
DC20185 |
Benzamidine HCl
Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively. |
1670-14-0 |
DC26053 |
Benzamil (hydrochloride)
Featured
Benzamil hydrochloride is a specific and potent sodium channel (ENaC) blocker. |
161804-20-2 |
DC22184 |
Benzarone
Benzarone (NSC 82134) is a small molecule inhibitor of Eyes Absen (EYA) protein tyrosine phosphatase activity (IC50=17 uM, EYA3), exhibits selectivity for EYA over PTP1B. |
1477-19-6 |
DC8895 |
benzbromaron
Featured
Benzbromarone is a highly effective and well tolerated non-competitive inhibitor of xanthine oxidase, used as an uricosuric agent, used in the treatment of gout. |
3562-84-3 |
DC9885 |
Benzenesulfonamide
Benzenesulfonamide ia an inhibitor of carbonic anhydrases |
98-10-2 |
DC20028 |
Benznidazole (Synonyms: Benznidazol; Ro 07-1051; Ro 71051)
Featured
Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease. |
22994-85-0 |
DC10223 |
Benzocaine hydrochloride
Benzocaine hydrochloride is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. |
23239-88-5 |
DC12173 |
Benzyl alcohol (Benzenemethanol)
Benzyl alcohol is an aromatic alcohol; a colorless liquid with a mild pleasant aromatic odor. |
100-51-6 |
DC20216 |
Benzylcetyldimethylammonium chloride hydrate
Benzylcetyldimethylammonium chloride hydrate is a chemical. |
122-18-9 |
DC22482 |
Bephenium hydroxynaphthoate
Bephenium hydroxynaphthoate is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis.. |
3818-50-6 |
DC22478 |
Bephenium
Bephenium is an anthelmintic compound that acts as an activiator of nematode B-type nAChR, is used in the treatment of hookworm infections and ascariasis.. |
7181-73-9 |
DCAPI1500 |
Bepotastine Besilate
Featured
Bepotastine Beslilate (Bepreve) is a histamine H1 receptor anatagonist. |
190786-44-8 |
DC8898 |
Bepotastine
Featured
Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. |
125602-71-3 |
DC11403 |
Bepridil hydrochloride
Featured
Bepridil hydrochloride is a calcium channel blocker, with antianginal activity. |
68099-86-5 |
DC21868 |
Berotralstat
Berotralstat is a potent human plasma kallikrein inhibitor. |
1809010-50-1 |
DC4143 |
Besifloxacin HCl
Featured
Besifloxacin HCl is a fourth-generation fluoroquinolone antibiotic. |
405165-61-9 |
DC21519 |
Besifovir
Besifovir (PMCDG Dipivoxil, NA-380, LB-80380) is a potent, selective, orally available anti-HBV agent, the prodrug of PMCDG (EC50=4 uM).. |
441785-26-8 |
DC11042 |
BET inhibitor CF53
BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1). |
1808160-52-2 |
DC21382 |
EIDD-1931(NHC)
Featured
EIDD-1931 (β-d-N4-Hydroxycytidine, NHC) inhibits both murine hepatitis virus (MHV) (EC50 of 0.17 μM) and Middle East respiratory syndrome CoV (MERS-CoV) (EC50 of 0.56 μM) with minimal cytotoxicity. It also inhibits SARS-CoV-2 and multiple 2 endemic, epide |
3258-02-4 |
DC10655 |
3-Guanidinopropionic acid
Featured
Beta-guanidinopropionic acid is a novel creatine kinase inhibitor. |
353-09-3 |
DC8967 |
Betahistine Dihydrochloride
Betahistine Dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug. |
5579-84-0 |
DC8830 |
Betahistine
Featured
Betahistine is a strong affinity histamine H3 receptor antagonist and weak affinity agonist of histamine H1 receptors. |
5638-76-6 |
DC7905 |
beta-Lapachone (ARQ-501, CO-501)
Featured
Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. |
4707-32-8 |
DCAPI1169 |
Betamethasone (Celestone)
Betamethasone (Celestone) |
378-44-9 |
DC12320 |
Betanin
Betanin has potent antioxidant and anti-inflammatory effect, that could inhibit peroxynitrite (ONOO-), with an IC50 of 19.2 μM. Betanin is a red glycoside obtained from beets that can be used as colorant. |
7659-95-2 |
DCAPI1040 |
Betapar(Meprednisone)
Betapar(Meprednisone) |
1247-42-3 |
DC11105 |
Umibecestat
Featured
beta-secretase inhibitor. |
1387560-01-1 |
DC8556 |
BET-BAY 002
BET-BAY 002 is a potent BET inhibitor; shows efficacy in a multiple myeloma model. |
1588521-78-1 |
DC7373 |
Betrixaban
Featured
Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). |
330942-05-7 |
DC11483 |
Betrixaban maleate
Featured
Betrixaban (PRT-054021) is a highly potent, selective, and orally efficacious factor Xa inhibitor with IC50 of 1.2 nM(inhibition of Factor 10a). |
936539-80-9 |
DC9832 |
Betulinic acid
Featured
Betulinic acid, a pentacyclic triterpene, selectively induces apoptosis in tumor cells, also is a inhibitor of HIV-1 with EC50 of 1.4 μ M. |
472-15-1 |
DC23068 |
Liquidambaric acid
Featured
Betulonic acid has anti-cancer , anti-HIV,hepatoprotective and anti-inflammatory activities, it has antiviral activity against herpes simplex virus, it also suppresses ECHO 6 virus reproduction. |
4481-62-3 |
DC9643 |
Bevirimat(PA-457)
Featured
Bevirimat(YK FH312; FH11327; MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound; is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. |
174022-42-5 |
DC8186 |
Bexagliflozin3
Featured
Bexagliflozin is a potent and selective SGLT2 inhibitor with IC50 value of 5.6 μM /2 nM in SGLT1 /SGLT2 respectively. |
1118567-05-7 |
DCAPI1078 |
Bexarotene
Bexarotene |
153559-49-0 |
DC8786 |
NVP-BEZ235 Tosylate
Featured
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
1028385-32-1 |
DC3136 |
NVP-BEZ235
Featured
BEZ235 (NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively, and also inhibits ATR with IC50 of 21 nM. |
915019-65-7 |
DC9088 |
Bezafibrate
Bezafibrate(BM15075) is the first clinically tested dual and pan-PPAR co-agonism. |
41859-67-0 |
DC12131 |
BF-227(E/Z)
Featured
BF 227 is a candidate for an amyloid imaging probe for PET, with a Ki of 4.3 nM for Aβ1-42 fibrils. |
845647-80-5 |
DC20797 |
BF 844
BF 844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K). |
1404506-35-9 |
DC12136 |
BF-168
BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42. |
634911-47-0 |
DC20767 |
BF738735
BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM). |
1436383-95-7 |
DC9956 |
BFH772
Featured
BFH772 is a potent oral VEGFR2 inhibitor, which is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. |
890128-81-1 |
DC8310 |
BG-45
Featured
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 µM, respectively). |
926259-99-6 |
DC10335 |
BGB-3111
BGB-3111 is a potent, selective and orally available Bruton's tyrosine kinase (Btk) inhibitor. |
1633350-06-7 |
DC22196 |
BGC20-1531
BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7. |
1962928-26-2 |
DC10059 |
BGG463
Featured
BGG463 can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with a 50% inhibitory concentration (IC50) of 0.25 μM, 0.09 μM and 0.590 μM, respectively. |
890129-26-7 |
DC5194 |
NVP-BGJ398(Infigratinib)
Featured
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. |
872511-34-7 |
DC8571 |
BGP-15
Featured
BGP-15 is a PARP inhibitor and insulin sensitizer. |
66611-37-8 |
DC9695 |
BH3I-1
Featured
BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL. BH3I-1 is an inhibitor of Bcl-xL. |
300817-68-9 |
DC21359 |
BHC
BHC (Myosin inhibitor BHC) is a small-molecule screen of skeletal muscle myosin inhibitor that suppresses movements without affecting membrane currents. |
342387-19-3 |
DC23177 |
BHPI
BHPI is a potent, noncompetitive small molecule ERα inhibitor (biomodulator) that selectively blocks proliferation of drug-resistant ERα-positive breast and ovarian cancer cells. |
56632-39-4 |
DC9426 |
B-HT 920
B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity. |
36085-73-1 |
DC21546 |
BI-1467335 HCl
Featured
BI 1467335 (PXS-4728A, PXS-4728) is a potent, selective, orally active SSAO/VAP-1 (AOC3) inhibitor with IC50 of 5 nM; displays >500-fold selective for VAP-1/SSAO over all the related human amine oxidases; diminishes leukocyte rolling and adherence induced by CXCL1/KC, also inhibits the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis. |
1478364-68-9 |
DC22021 |
BI 167107
Featured
BI 167107 is a highly potent agonist of the β2 adrenergic receptor (β2AR) and β1AR (IC50=3.2 nM) and shows some activity as α1A antagonist (IC50 = 32 nM). |
1202235-68-4 |
DC20776 |
BI 187004
BI 187004 (VTP-34072) is a novel potent, selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor intended to treat type 2 diabetes mellitus (T2D).. |
1303515-32-3 |
DC20778 |
BI 207524
BI 207524 is a potent inhibitor of HCV thumb pocket 1 NS5B inhibitor with IC50 of 84 nM, inhibits Gt 1a/1b replicons with EC50 of 29/11 nM.. |
874675-53-3 |
DC11389 |
BI 409306
Featured
BI 409306 is an inhibitor of phosphodisterase 9A(PDE9A). |
1189767-28-9 |
DC22026 |
BI 665915
BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM. |
1360550-04-4 |
DC20781 |
BI 671800
Featured
BI 671800 is a potent, oral prostaglandin D2 receptor (CRTH2) antagonist for treatment of asthma.. |
1093108-50-9 |
DC23527 |
BI 6901
BI 6901 is a potent, selective CCR10 antagonist with Aequorin Ca2+ flux pIC50 of 9.0, shows high selectivity over other GPCRs. |
2040401-92-9 |
DC23347 |
BI 7189
BI 7189 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9, displays >1,000 fold selectivity over the bromodomains of BRD4. |
1883429-32-0 |
DC23391 |
BI 7271
BI 7271 is a highly selective bromodomains of BRD9 and BRD7 inhibitor with IC50<50 nM for BRD9. |
1883429-34-2 |
DC20783 |
BI 831266
BI 831266 is a potent, selective inhibitor of Aurora kinase B (AURKB) with IC50 of binding IC50 of 42 nM. |
958227-46-8 |
DC11760 |
BI 885578
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively. |
|
DC23348 |
BI 894999
BI 894999 is a novel potent, selective BET inhibitor with IC50 of 5 and 41 nM for BRD4-BD1 and BRD4-BD2 bromodomains, respectively. |
1660117-38-3 |
DC23560 |
BI01383298
Featured
BI01383298 (BI-01383298) is a potent, specific sodium-citrate co-transporter SLC13A5 (NaCT, INDY), highly selective over other family members and other transporters.. |
2227549-00-8 |
DC12406 |
BI-0314
Featured
BI-0314 (BI0314) is an allosteric activator of protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) with potency of 56% at 500 uM, displays no activity against hPTP1B and hTCPTP. |
2244560-46-9 |
DC23049 |
BI1002494
BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
1319738-39-0 |
DC20775 |
BI-1347
Featured
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC with IC50 of 1 nM. |
2163056-91-3 |
DC11842 |
BI 135585
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
1114561-85-1 |
DC22020 |
BI-1388
BI-1388 is a potent, specific, macrocyclic inhibitor of HCV NS3 protease, inhibits viral replication for various HCV genotypes and for resistant mutants D168V and R155K. |
1309952-03-1 |
DC20777 |
BI-1935
BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM. |
940954-41-6 |
DC22022 |
BI-1950
BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM. |
1159724-42-1 |
DC7083 |
Bi 2536
Featured
BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM, BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3; BI2536 also is a BRD4 inhibitor(IC50= 25 nM). |
755038-02-9 |
DC11602 |
BI-2545
BI-2545 is a novel potent, selective, orally available Autotaxin inhibitor with IC50 of 2.1 and 3.4 nM for huamn and rat ATX, respectively. |
2162961-71-7 |
DC22023 |
BI-3663
BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines. |
|
DC20779 |
BI-3802
Featured
BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM. |
2166387-65-9 |
DC23310 |
BI-3812
Featured
BI-3812 is potent and efficacious BCL6 inhibitor, inhibiting the BTB domain of BCL6, with an IC50 of ≤3 nM; BI-3812 has antitumor activity. |
2166387-64-8 |
DC22024 |
BI-4394
BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM). |
1222173-37-6 |
DC22310 |
BI-4464
Featured
BI-4464 (BI 4464) is a potent, highly selective, ATP competitive inhibitor of Focal adhesion tyrosine kinase (PTK2/FAK) with IC50 of 17 nM.. |
1227948-02-8 |
DC11960 |
BI605906
Featured
BI605906 is a potent, specific IKKβ inhibitor with IC50 of 380 nM (0.1 mM ATP), does not suppress signaling downstream of mTOR or activate AMPK. |
960293-88-3 |
DC7107 |
BI-78D3
Featured
BI-78D3 is a competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. |
883065-90-5 |
DC8401 |
BI-847325
Featured
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. |
1207293-36-4 |
DC20784 |
BI8622
BI8622 (BI-8622) is a specific small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 3.1 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b). |
1875036-74-0 |
DC20785 |
BI8626
BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM). |
1875036-75-1 |
DC9888 |
BI-9564
Featured
BI-9564 is a selective, and cell-permeable BRD9 BD inhibitor, with Kd of 5.9 nM for BRD9, and IC50 of > 100 μM for BET family. |
1883429-22-8 |
DC23608 |
BI-9627
BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. |
1204329-34-9 |
DC12567 |
BI-9667
BI-9667 (BI9667) is a potent, selective CCR1 antagonist.. |
1295298-26-8 |
DC22027 |
BI-99179
BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM. |
1291779-76-4 |
DC10404 |
BIA 10-2474
Featured
BIA 10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 values of 50 to 70mg/kg in various rat brain regions. |
1233855-46-3 |
DC4206 |
Biapenem
Biapenem is a carbapenem antibiotic. |
120410-24-4 |
DC23366 |
biBET
biBET is a potent, selective, bivalent inhibitor of BET bromodomains with pKd of 8.3/7.3/11 for BRD4(1)/BRD4(2)/BRD4(1,2), respectively. |
2059110-46-0 |
DC20788 |
BIBO-3304
Featured
BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively. |
191868-14-1 |