Cat. No. | Product name | CAS No. |
DC20266 |
Chelerythrine
Featured
Chelerythrine is a well-known protein kinase C inhibitor, can inhibit telomerase activity, it also can block the human P2X 7 receptor. |
34316-15-9 |
DC20100 |
Chelidonic acid
Featured
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blo |
99-32-1 |
DC12205 |
CHEMBL333994 (FK-480)
CHEMBL333994 is a potent and orally effective Cholecystokinin A (CCK-A) antagonist, with an IC50 of 0.67 nM. |
167820-10-2 |
DC20338 |
Chemocoxib A
Chemocoxib A is a highly potent, selective, cytotoxic COX-2 inhibitor with IC50 of 290 nM and 90 nM for wt mCOX-2 and R120Q COX-2 mutant respectively. |
960214-84-0 |
DC21405 |
Chetomin
Featured
Chetomin (NSC 289491) is a natural product isolated from Chaetomium species which shows antibacterial and antifungal properties, disrupts the interaction of HIF-1α/p300 at low nanomolar concentrations, strongly increases retinal pigment epithelial cells d |
1403-36-7 |
DC7978 |
Tucidinostat(Chidamide)
Featured
Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on HDAC4/5/7/9/6(IC50>30 uM). |
743420-02-2 |
DC12515 |
Chiglitazar
Chiglitazar (CS-038, CS038) is a potent, dual PPARα/γ dual agonist with EC50 of 1.2, 0.08, 1.7 uM for PPARα, PPARγ and PPARδ, respectively. |
1959588-75-0 |
DC9292 |
CHIR-090
Featured
CHIR-090 is a potent LpxC inhibitor, displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. |
728865-23-4 |
DC7384 |
CHIR-98014
Featured
CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. |
252935-94-7 |
DC9703 |
CHIR-99021 HCl
Featured
CHIR-99021 HCl is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo. |
1797989-42-4 |
DC1023 |
CHIR-99021 (CT99021)
Featured
CHIR-99021 is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo. |
252917-06-9 |
DC12323 |
CHK1-IN-2
CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM |
912367-45-4 |
DC9048 |
Chloroambucil
Chlorambucil(WR-139013; CB-1348) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia. |
305-03-3 |
DCAPI1255 |
Chloramphenicol (Chloromycetin)
Chloramphenicol (Chloromycetin) |
56-75-7 |
DC12124 |
Chlorantraniliprole
Featured
Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ∼300-fold more potent than that in the mouse myobla |
500008-45-7 |
DCAPI1167 |
Chlorhexidine HCl
Chlorhexidine hydrochloride is an antiseptic effective against a wide variety of gram-negative and gram-positive organisms. |
3697-42-5 |
DCAPI1354 |
Chlormezanone (Trancopal)
Chlormezanone (Trancopal) |
80-77-3 |
DC9169 |
Chloroquine diphosphate
Chloroquine diphosphate is an antimalarial drug and autophagy/lysosome inhibitor; inhibits Toll-like receptor (TLR) signalling in plasmacytoid dendritic cells (pDCs). |
50-63-5 |
DCAPI1270 |
Chlorothiazide
Chlorothiazide |
58-94-6 |
DC9111 |
Chlorpheniramine Maleate
Chlorpheniramine maleate is an histamine H1 receptor antagonist with IC50 of 12 nM. |
113-92-8 |
DC9082 |
Chlorpromazine HCl
Featured
Chlorpromazine Hydrochloride is a dopamine and potassium channel inhibitor used as the prototypical phenothiazine antipsychotic drug. |
69-09-0 |
DC9062 |
Chlorprothixene
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
113-59-7 |
DCAPI1339 |
Chlorthalidone (Chlortalidone)
Chlortalidone is a diuretic drug used to treat hypertension. |
77-36-1 |
DC9194 |
Chlorzoxazone
Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to qua |
95-25-0 |
DC20623 |
CHMFL-ABL-053
CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM. |
1808287-83-3 |
DC10467 |
CHMFL-BMX-078
Featured
CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM. |
1808288-51-8 |
DC20339 |
CHMFL-KIT-031
CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt. |
|
DC20069 |
CHMFL-PI3KD-317
CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3 |
2244992-76-3 |
DC12199 |
Cholestenone
Cholestenone is the intermediate oxidation product of cholesterol. |
601-57-0 |
DC20181 |
Choline Fenofibrate;ABT-335
Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist. |
856676-23-8 |
DC8116 |
Tosedostat (CHR2797)
Featured
CHR-2797 is an aminopeptidase inhibitor, with IC50 values of 100 nM for LAP3 (LAP), 150 nM for PSAP (PuSA) and 220 nM for CD13 (Aminopeptidase N). |
238750-77-1 |
DC22173 |
CHR-3996
CHR-3996 (Nanatinostat, VRx-3996, CHR3996, Tractinostat) is a potent, class I-selective, orally active HDAC inhibitor with IC50 of 3-7 nM for HDAC1/2/3. |
1256448-47-1 |
DC9460 |
CHR-6494
Featured
CHR-6494 is a potent and selective Haspin (Haploid Germ Cell-Specific Nuclear Protein Kinase) inhibitor that blocks H3T3ph phosphorylation. |
1333377-65-3 |
DC8139 |
GMX1778(CHS-828)
Featured
CHS-828 is a pyridyl cyanoguanidine anti-tumor agent that has been identified as a competitive inhibitor of Nampt as well as an inhibitor of NF-κB pathway activity. |
200484-11-3 |
DC12329 |
ChX710
ChX710 could prime the type I interferon response to cytosolic DNA, which induces the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3. |
2438721-44-7 |
DC10341 |
CHZ868
CHZ868 is a type II JAK2 inhibitor with an IC50 of 0.17 μM in EPOR JAK2 WT Ba/F3 cell. |
1895895-38-1 |
DC2088 |
CI-1040 (PD184352)
Featured
CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM. |
212631-79-3 |
DC20893 |
CI-1044
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities. |
197894-84-1 |
DC21462 |
CI-966
CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively. |
110283-79-9 |
DC20894 |
CI-966 hydrochloride
CI-966 is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively. |
110283-66-4 |
DC21463 |
CI-976
Featured
CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM. |
114289-47-3 |
DC2060 |
CI994 (Tacedinaline)
Featured
CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
112522-64-2 |
DC12412 |
cIAP1 E3 ligase inhibitor D19
cIAP1 E3 ligase inhibitor D19 (cIAP1 inhibitor D19) is a small-molecule inhibitor of E3 ligase activity of cIAP1, inhibits cIAP1 auto-ubiquitination with IC50 of 14.1 uM, shows no effect on autoubiquitination of BRCA1/BARD1. |
380640-76-6 |
DC12413 |
cIAP1 E3 ligase inhibitor D19-14
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro. |
|
DC9176 |
Ciclesonide
Ciclesonide(RPR251526) is a glucocorticoid used to treat obstructive airway diseases. |
126544-47-6 |
DCAPI1143 |
Ciclopirox (Penlac)
Ciclopirox (Penlac) |
29342-05-0 |
DC12285 |
CID 1375606
Featured
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. |
313493-80-0 |
DC10873 |
CID16020046
Featured
CID 16020046 is a potent and selective GPR55(LPI receptor) antagonist; inhibitsGPR55 constitutive activity with IC50 of 0.15 uM. |
834903-43-4 |
DC22056 |
CID 9998128
CID 9998128 is a potential multi-target drug for the Alzheimer's disease (AD), inhibits the Aβ42 amyloid fibrillization and is capable to clear Aβ42 fibrils. |
733807-13-1 |
DC12243 |
CID-1067700
CID-1067700 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM. |
314042-01-8 |
DC7253 |
CID-2011756
Featured
CID-2011756 is a cell-active ATP competitive and specific PKD1 inhibitor that inhibits phorbol ester-induced endogenous PKD1 activation in LNCaP prostate cancer cells. |
638156-11-3 |
DC8849 |
CID-2858522
Featured
CID-2858522 is a selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). |
758679-97-9 |
DC20895 |
CID3528206
CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively. |
674359-78-5 |
DC9955 |
BCL6 inhibitor(CID5721353)
Featured
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). |
301356-95-6 |
DC7385 |
CID-755673
Featured
CID755673 is a potent and selective cell-active small molecule inhibitor for PKD with an IC50 of 182 nM; exhibits selective PKD1 inhibition when compared with AKT, PLK1, CAK, CAMKIIα, and PKC isoforms. |
521937-07-5 |
DC7976 |
CID 797718
Featured
CID-797718 is a compound with unknown details. |
370586-05-3 |
DC23753 |
CID888706
CID888706 is a small molecule, pan activator of Rho-family GTPases.. |
496775-95-2 |
DC20904 |
CIDD 0067106
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
2151865-39-1 |
DCAPI1021 |
Cidofovir(Vistide)
Featured
Cidofovir(Vistide) |
113852-37-2 |
DC10839 |
CIL56(CA3)
Featured
CIL56 is a small molecule that induces cellular ferroptosis through production of iron-dependent reactive oxygen species (ROS). |
300802-28-2 |
DC11374 |
Cilastatin
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. |
82009-34-5 |
DCAPI1569 |
Cilostazol
Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazo |
73963-72-1 |
DC9325 |
Cilazapril (monohydrate)
Featured
Cilazapril Monohydrate is a angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and congestive heart failure. |
92077-78-6 |
DC7561 |
Cilengitide (TFA salt)
Featured
Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2. |
199807-35-7 |
DC9875 |
Ciliobrevin A(HPI4)
Featured
Ciliobrevin A(HPI-4) is a Hedgehog pathway inhibitor and ciliogenesis inhibitor. |
302803-72-1 |
DC20341 |
Ciliobrevin D
Featured
Ciliobrevin D is a cell-permeable, reversible, specific inhibitor of cytoplasmic dynein, blocks dynein-dependent microtubule gliding and ATPase activity while sparing kinesin dependent cellular trafficking. |
1370554-01-0 |
DC9160 |
Cilnidipine
Featured
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. |
132203-70-4 |
DC10868 |
Cilofexor
Featured
Cilofexor (GS-9674, GS9674) is novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models. |
1418274-28-8 |
DC9582 |
Cilomilast
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
153259-65-5 |
DC22028 |
Ciluprevir
Ciluprevir (BILN2061) is a potent HCV NS3/4A protease inhibitor with Ki of 0.66 and 0.30 nM for NS3-NS4A protease of HCV 1b and HCV 1a, respectively. |
300832-84-2 |
DC9002 |
Cimetidine
Cimetidine is a histamine-2 (H2) receptor antagonist. |
51481-61-9 |
DC12134 |
Cimiside B
Cimiside B, a glycoside alkaloid, isolated from the rhizome of Cimicifuga dahurica. |
152685-91-1 |
DC8801 |
Cinacalcet (AMG-073)
Featured
Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
226256-56-0 |
DC12369 |
Cinaciguat (hydrochloride)
Featured
Cinaciguat is an activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM). |
646995-35-9 |
DC20093 |
Cinchonine ((8R,9S)-Cinchonine; LA40221)
Featured
Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. |
118-10-5 |
DC9174 |
Cinepazide maleate
Cinepazide Maleate is a vasodilator. |
26328-04-1 |
DC9896 |
Cinnarizine
Featured
Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker. |
298-57-7 |
DCH-062 |
Cinobufotalin
Featured
Cinobufotalin is a steroid glycoside originally isolated from the Asiatic toad (B. gargarizans) and has diverse biological activities. |
1108-68-5 |
DC22295 |
Cintirorgon sodium
Featured
Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist. |
2055538-47-9 |
DC22329 |
Cintirorgon
Featured
Cintirorgon (LYC-55716) is novel oral RAR-related orphan receptor γ (RORγ) agonist. |
2055536-64-4 |
DC21572 |
Cipemastat
Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9). |
174265-38-4 |
DC9603 |
Ciprofibrate
Ciprofibrate is a peroxisome proliferator-activated receptor agonist. |
52214-84-3 |
DCAPI1372 |
Ciprofloxacin (Cipro)
Featured
Ciprofloxacin (Bay-09867) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. |
85721-33-1 |
DC2062 |
Ciproxifan (FUB-359)
Featured
Ciproxifan is an antagonists of H3-type histamine receptors. |
184025-18-1 |
DC9466 |
Ciproxifan (maleate)
Featured
Ciproxifan maleate(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes. |
184025-19-2 |
DC8156 |
CIQ
Featured
CIQ is a positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC50 = 2.7 and 2.8 µM for NR2C and NR2D, respectively). |
486427-17-2 |
DC8187 |
Ciraparantag(PER977)
Featured
Ciraparantag(PER977) is an intravenously administered anticoagulant Reversal Agent. |
1438492-26-2 |
DC12100 |
Cirsimaritin
Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors, with antidepressant, anxiolytic and antinociceptive activities. |
6601-62-3 |
DC20342 |
cis Ned-19
cis Ned-19 is the stereoisomer of trans Ned-19, a chemical probe for the Ca(2+)-releasing second messenger NAADP. |
1137264-00-6 |
DCAPI1600 |
Cisapride
Featured
Cisapride is a SR-4 agonist also known as Enteropride |
81098-60-4 |
DC9517 |
Cisatracurium (besylate)
Featured
Cisatracurium Besylate is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission. |
96946-42-8 |
DC2099 |
cis-Diaminedichloroplatinum
Featured
Cisplatin is an inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity. |
15663-27-1 |
DC9118 |
Citalopram HBr
Citalopram hydrobromide is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has US FDA approval to treat major depression. |
59729-32-7 |
DC12668 |
Citarinostat(ACY-241)
Featured
Citarinostat(ACY-241) is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. |
1316215-12-9 |
DCAPI1527 |
Citicoline Sodium
Citicoline Sodium |
33818-15-4 |
DC20906 |
CJ-13610
Featured
CJ-13610 is a potent 5-Lipoxygenase (5-LO) inhibitor that suppresses 5-LO product formation with IC50 of 70 nM. |
179420-17-8 |
DC20907 |
CK 666
Featured
CK 666 (CK 0944666) is a small molecule Arp2/3 complex inhibitor with IC50 of 4 uM, inhibits actin polymerization with either BtArp2/3 complex (IC50=17 uM) or SpArp2/3 complex (IC50=5 uM). |
442633-00-3 |
DC20343 |
CK1-IN-3c
CK1-IN-3c is a novel casein kinase 1δ/ε (CK1δ/ε) inhibitor with IC50 of 1.6 uM. |
756805-89-7 |
DC11673 |
CK-2127107
Featured
CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM. |
1345410-31-2 |
DC20344 |
CK2-IN-1
CK2-IN-1 is a potent, competitive inhibitor of ATP binding to Casein kinase 2(CK2) with IC50 of 9 nM, induces differentiation of epidermal progenitor cells to terminally differentiated keratinocytes with EC50 of 0.1 uM.. |
863598-09-8 |
DC7386 |
CK-636
Featured
CK-636(CK-0944636) is a small molecule inhibitor of Arp2/3 complex; Inhibitor of actin polymerization; Cell permeable inhibitor of human (IC50=4μM), fission yeast (IC50=24μM) and bovine (IC50=32μM) Arp2/3 complex between Arp2 and Arp3. |
442632-72-6 |
DC11475 |
CK-869
Featured
CK-869 is an inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. |
388592-44-7 |
DC11107 |
CKD-516
CKD-516 (Valecobulin, CKD516) is a potent beta-tubulin polymerization inhibitor with marked antitumor activity both in vitro and in vivo. |
1188371-47-2 |
DC11098 |
CKD-519
CKD-519 (Rocacetrapib, CKD519) is a potent, selective cholesteryl ester transfer protein (CETP) inhibitor, inhibits the CETP-mediated transfer of cholesteryl ester in human serum with IC50 of 2.3 nM. |
1402796-27-3 |
DC20847 |
CL 316243
CL 316243 (BTA 243) is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM. |
183720-02-7 |
DC20909 |
CL 316243 disodium
CL 316243 is a potent, highly selective, orally active β3-adrenoceptor agonist with EC50 of 3 nM. |
138908-40-4 |
DC12595 |
CL27c
Featured
CL27c is a cell-permeable, inhaled lipophilic ester prodrug of CL27e, which is a potent, selective pan-class I PI3K inhibitor, CL27c is inactive in PI3K enzymatic assay, once inside the cytoplasm, CL27c is metabolized by unspecific esterases into CL27e. |
1380227-11-1 |
DC7668 |
CL-387785
Featured
CL-387785(EKI785; WAY-EKI 785) is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level. |
194423-06-8 |
DC20910 |
CL-82198 hydrochloride
CL-82198 is a potent, selective inhibitor of MMP-13 (89% inhibition at 10 ug/mL), displays no activity at MMP-1, MMP-9 and TACE, significantly reduces the migration of LS174 cells by 55% at 10 uM.. |
1188890-36-9 |
DC4205 |
Cladribine
Cladribine (Leustatin, Litak, 2CDA) is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
4291-63-8 |
DC12292 |
Cl-amidine hydrochloride
Featured
Cl-amidine (hydrochloride) is a peptidylarginine deminase (PAD) inhibitor, with an IC50 5.9 μM for PAD4. |
1373232-26-8 |
DC9725 |
Cl-amidine
Featured
Cl-amidine is a cell-permeable compound that acts as a pan PAD inhibitor (IC50 = 0.8 µM, 6.2 µM and 5.9 µM for PAD1, PAD3, and PAD4, respectively) in enzymatic assays. |
1043444-18-3 |
DC9868 |
Clanfenur
Featured
Clanfenur is a substituted benzoylphenylurea and an analogue of the pesticide diflubenzuron with potential antineoplastic activity. |
51213-99-1 |
DC8937 |
Clarithromycin
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. |
81103-11-9 |
DC12407 |
Class I and IIB HDAC inhibitor 42
Class I and IIB HDAC inhibitor 42 is a novel potent, selective class I and IIB inhibitor (HDAC1 Ki=0.27 nM) for topical treatment of cutaneous t-cell lymphoma.. |
2245323-24-2 |
DC7387 |
Clemizole Hydrochloride
Featured
Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
1163-36-6 |
DC8832 |
Clemizole (free base)
Featured
Clemizole is a H1 histamine receptor antagonist.Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
442-52-4 |
DC9380 |
Cleviprex
Featured
Clevidipine(Clevidipine) is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ) under development for treatment of perioperative hypertension. |
167221-71-8 |
DCAPI1085 |
Clevudine (Levovir)
Featured
Clevudine (Levovir) is an antiviral drug for the treatment of hepatitis B,showed potent activity against COVID-19(SARS-COV-2) . |
163252-36-6 |
DCAPI1113 |
Clindamycin HCl (Dalacin)
Clindamycin HCl (Dalacin) |
21462-39-5 |
DCAPI1131 |
Clindamycin phosphate
Clindamycin phosphate |
24729-96-2 |
DC10204 |
Clinofibrate
Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor. |
30299-08-2 |
DC10242 |
5-Chloro-8-hydroxy-7-iodoquinoline
Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. |
130-26-7 |
DC21722 |
CLK-IN-T3
Featured
CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively. |
2109805-56-1 |
DC11004 |
CLK2 inhibitor Indazole1
CLK2 inhibitor Indazole1 is a novel potent, selective inhibitor of CLK2 with IC50 of 2.7 nM, 60-fold selectivity over PKA and >600-fold selectivity over a panel of 34 kinases. |
|
DC23464 |
Clobenpropit
Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors. |
145231-45-4 |
DC23440 |
Clobenpropit dihydrobromide
Clobenpropit (VUF-9153) is a highly potent histamine H3 antagonist/inverse agonist with pA2 value of 9.93, also displays partial agonist activity at H4 receptors. |
145231-35-2 |
DCAPI1133 |
Clobetasol propionate
Clobetasol propionate |
25122-46-7 |
DC12304 |
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate)
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors. |
60789-62-0 |
DCAPI1428 |
Clofarabine
Featured
Clofarabine(Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. IC50 Value: 65 nM Target: in vitro: Clofarabine is a second generation purine nucleoside analog with antineoplastic activity. It |
123318-82-1 |
DC9156 |
Clofazimine
Clofazimine is a fat-soluble iminophenazine dye, has a marked anti-inflammatory effect, has been used in combination with other antimycobacterial drugs to treat AIDS and Crohn's disease. |
2030-63-9 |
DC8681 |
Clofentezine
Clofentezine, a growth inhibitor, has sublethal effects on life-table parameters of Tetranychus urticae Koch females. |
74115-24-5 |
DC9183 |
Clomiphene citrate
Clomifene Citrate is a selective estrogen receptor modulator. |
50-41-9 |
DC9081 |
Clomipramine HCL
Clomipramine HCl is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
17321-77-6 |
DC9021 |
Clonidine hydrochloride
Clonidine Hydrochloride is a centrally acting alpha-agonist hypotensive agent. |
4205-91-8 |
DC3147 |
Clopidogrel hydrogensulfate
Clopidogrel (Plavix) is an oral, thienopyridine class antiplatelet agent. |
120202-66-6 |
DCAPI1417 |
Clopidogrel
Clopidogrel is an irreversible inhibitor of the P2Y12 receptor, which is responsible for initiating signal transduction via a GPCR. The signal cascade initiates platelet aggregation and thus clopidogrel has the effect of “thinning” the blood. |
113665-84-2 |
DCAPI1545 |
Cloprostenol sodium
Cloprostenol Sodium is a synthetic F series prostaglandin that functions as a potent agonist towards the PGF2αR (FP receptor). It is known that Cloprostenol Sodium is less selective than other agonists such as fluprostenol, however it displays more potenc |
55028-72-3 |
DC8672 |
Cloquintocet-mexyl
Cloquintocet-mexyl is a herbicide, used to control coarse annual grass of the family poaceae (gramineae). |
99607-70-2 |
DC7991 |
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide
Featured
Clozapine N-oxide is a major metabolite of Clozapine noted to decrease SR-2A (5-HT2 serotonin receptor) density in vitro. |
34233-69-7 |
DC9067 |
Clozapine
Clozapine(HF 1854) is a 5-HT2A/2C and dopamine receptor blocker with Ki values of 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively. |
5786-21-0 |
DC12714 |
CLP-290
Featured
CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257; In vivo co-treatment with morphine and oral CLP290 prevented membrane KCC2 downregulation in SDH neurons. Concurrently, co-treatment with CLP290 significantly mitigated MIH and acute administration of CLP257 in established MIH restored normal nociceptive behavior. |
1181083-81-7 |
DC11061 |
ClpP inhibitor M21
ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay. |
1151944-58-9 |
DC9797 |
18-[4-(2,2-Difluoro-3-aza-1-azonia-2-boranuidatricyclo[7.3.0.03,7]dodeca-1(12),4,6,8,10-pentaen-8-yl)phenyl]octadecyl-[2-(trimethylazaniumyl)ethoxy]phosphinate
Featured
CLR1501 is a synthetic analogs of the tumor-targeting agent alkylphosphocholine (APC), which is specifically attracted to cancer cells. |
1250963-36-0 |
DC11067 |
CLSP37
CLSP37 (RIPK2 inhibitor CLSP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
|
DC11068 |
CLSP43
CLSP43 (RIPK2 inhibitor CLSP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
|
DC21063 |
CM03
CM03 is a G-quadruplex-binding compound that potently inhibits cell growth in PDAC cell lines (MIA PaCa-2 IC50=19 nM). |
2101208-44-8 |
DC10795 |
CM-272
Featured
CM-272 is a first-in-class reversible dual small molecule inhibitor against G9a and DNMTs in hematological malignancies. |
1846570-31-7 |
DC7605 |
CM346(Afobazole)
Featured
CM-346 increased the power of the low-frequency θ-rhythm (4.8–5.8 Hz) and the dominant activity peak (6.0–7.2 Hz) and decreased the spectral power in the 19–20 Hz band. |
173352-21-1 |
DC12629 |
CM-675
CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively. |
1872466-47-1 |
DC20913 |
CMA-008
CMA-008 is a cell-permeable, small molecule modulator of NAADP-mediated Ca2+ release, competes with NAADP binding, inhibit Ca2+ release via the NAADP receptor (IC50=15 uM-1 mM). |
854091-96-6 |
DCAPI1542 |
CMC·HCI
CMC·HCI |
51391-96-9 |
DC23813 |
CMC2.24
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo. |
1255639-43-0 |
DC7388 |
c-Met inhibitor 1
c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. |
1357072-61-7 |
DC9617 |
CMK
CMK is a RSK2 kinase inhibitor. |
821794-90-5 |
DC21530 |
CMP-5
Featured
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
880813-42-3 |
DC21531 |
CMP-5 hydrochloride
CMP-5 (PRMT5-IN-5)is a first-in-class, small-molecule PRMT5-specific inhibitor that blocks EBV-driven B-lymphocyte transformation and survival, without effect on normal B cells. |
1030021-40-9 |
DC9803 |
CMP8
Featured
CMP8 is a high-affinity ligand that binds only to mutant ERLBD. |
851107-28-3 |
DC23508 |
CMPD167
CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).. |
313994-79-5 |
DC22512 |
CMPDA
Featured
CMPDA is a potent positive allosteric modulator of GluR2 receptors with EC50 of 45.4 and 63.4 nM at GluR2i and GluR2o respectively, in a calcium influx screening assays. |
380607-77-2 |
DC7761 |
Brincidofovir (CMX-001)
Featured
CMX001 (Brincidofovir; HDP-CDV) was developed as an orally active, lipophilic form of cidofovir (CDV); has enhanced activity in vitro and in vivo compared to CDV against certain herpesviruses, adenoviruses and orthopoxviruses.IC50 Value: 5.5 nM (EC50, in PDA at 7 dpi) [3]Target: anti-CMVCMX001 is currently in Phase II clinical studies for development as a therapeutic agent for human CMV, adenovirus and BK virus infections, as well as, for adverse events following smallpox vaccinations.in vitro: In PDA at 7 dpi, the CMX001 50% effective concentration (EC50) was 5.55 nM, the 50% cytotoxic concentration (CC50) was 184.6 nM, and the 50% selectivity index (SI50) was 33.3. The EC90 was 19.7 nM, the CC90 was 5,054 nM, and the SI90 was 256.1. In COS-7 cells, JCV replication was faster and the EC50 and EC90 were 18- and 37-fold higher than those in PDA, i.e., 0.1 μM and 0.74 μM (CC50, 0.67 μM; SI50, 6.7; CC90, 12.2 μM; SI90, 16.5) at 5 dpi [3].in vivo: CMX001 and CDV are equally efficacious at protecting mice from mortality following high ectromelia virus doses (10,000 x LD(50)) introduced by the intra-nasal route or small particle aerosol. Using CMX001 at a 10mg/kg dose followed by 2.5mg/kg doses every other-day for 14 days provided solid protection against mortality and weight loss following an intra-nasal challenge of (100-200) x LD(50) of ectromelia virus [1]. When CMX001 was administered orally to mice infected with HSV-1, mortality was reduced significantly (p≤0.001) with all three dose levels when treatments were initiated 24 h post viral inoculation. When treatments were started 48 h post viral inoculation, 5 and 2.5 mg/kg significantly reduced mortality (p≤ 0.001). If treatments were delayed until 72 h post viral inoculation, CMX001 did not reduce mortality or increase the mean day to death. When mice were infected intranasally with HSV-1 and treatments initiated 24 h post viral inoculation using CMX001 at 5 mg/kg or ACV at 100 mg/kg, virus replication in target organs was reduced by both CMX001 and ACV when compared to vehicle treated mice [2]. Toxicity: Diarrhea was the most common adverse event in patients receiving CMX001 at doses of 200 mg weekly or higher and was dose-limiting at 200 mg twice weekly. Myelosuppression and nephrotoxicity were not observed [4]. |
444805-28-1 |
DC12476 |
CN427
Featured
CN427 (CN-427) is novel BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM.. |
|
DC12477 |
CN750
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM. |
2098711-72-7 |
DC10752 |
CNDAC HCl
Featured
CNDAC (DFP-10917; TAS-109) is an orally available deoxycytosine nucleoside analog with potential antineoplastic activity. |
134665-72-8 |
DC9799 |
CNDAC
Featured
CNDAC is the active component of sapacitabine. |
135598-68-4 |
DC9370 |
CNP-AFU
CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is a substrate for alpha-L-fucosidase(AFU). |
157843-41-9 |
DC10671 |
CNQX disodium salt
Featured
CNQX is a potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. |
479347-85-8 |
DC10670 |
CNQX
Featured
CNQX is a potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. |
115066-14-3 |
DC7009 |
CNS-7056
CNS 7056 is a new short-acting sedative/anaesthetic that acts on GABAA receptors in the brain. |
308242-62-8 |
DC20346 |
CN-SAH
CN-SAH is a potent and selective inhibitor of histone methyl transferase DOT1L with IC50 of 26 nM, displays >10-fold selectivity over DNMT1, PRMT3, PRMT5, and G9α.. |
1985669-27-9 |
DC12103 |
CNT2 inhibitor-1
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC50 of 640 nM for hCNT2. |
880155-70-4 |
DC23180 |
CNV1014802(Raxatrigine)
Featured
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo. |
934240-30-9 |
DC8095 |
Raxatrigine hydrochloride
Featured
CNV1014802(GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor. |
934240-31-0 |
DC7104 |
CNX-1351
CNX-1351 is a selective covalent Inhibitor of PI3Kα. CNX-1351 was tested against all four of the class I PI3K enzymes α, β, γ, and δ. |
1276105-89-5 |
DC7105 |
CNX-2006
Featured
CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR. |
1375465-09-0 |
DC7161 |
CNX-774
Featured
CNX-774 is a potent, selective, and orally available small molecule inhibitor of Btk (IC50< 1 nM) that forms a ligand-directed covalent bond with Cys-481, a non-conserved amino acid within the active site of the enzyme. |
1202759-32-7 |
DC8651 |
CO-1686 hydrobromide
Featured
CO-1686 hydrobromide is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M (IC50=21 nM). |
1446700-26-0 |
DC7106 |
Rociletinib (CO-1686)
Featured
CO-1686 is a novel, irreversible and orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M(IC50=21 nM). |
1374640-70-6 |
DC2046 |
Cobicistat (GS-9350)
Featured
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
1004316-88-4 |
DC24119 |
Cobimetinib racemate
Cobimetinib racemate is the racemate form of Cobimetinib (GDC-0973, XL518), which is a potent, highly selective inhibitor of MEK1/2.. |
934662-91-6 |
DC22505 |
Cobimetinib R-enantiomer
Cobimetinib R-enantiomer (GDC-0973. |
934660-94-3 |
DC11081 |
Coblopasvir
Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection.. |
1312608-46-0 |
DC8863 |
Coelenterazine
Featured
Coelenterazine is a luminescent enzyme substrate, used for monitoring reporter genes in BRET, ELISA and HTS techniques. |
55779-48-1 |
DC10336 |
Coenzyme Q9
Featured
Coenzyme Q9, a nine isoprenyl group-containing member of the ubiquinone family, is a normal constituent of human plasma. |
303-97-9 |
DC10430 |
COH29
COH29 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity with an IC50 of 8 μM in KB cell. |
1190932-38-7 |
DC22149 |
COH-SR4
COH-SR4 (Mitochondria uncoupler SR4) is a bonafide uncoupler that induces energetic stress on cells, consequently leading to AMPK activation and mTOR inhibition without any effects on ERK/MEK MAPK signaling. |
73439-19-7 |
DC23785 |
Col 003
Col 003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47. |
328565-16-8 |
DC7813 |
Collagen proline hydroxylase inhibitor
Collagen proline hydroxylase inhibitor is a collagen proline hydroxylase inhibitor; useful for antifibroproliferative agents. |
223666-07-7 |
DC7608 |
OXi-4503
Combretastatin A1 diphosphate OXi4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. |
288847-35-8 |
DC11955 |
Takeda compound 101
Featured
Compound 101 (GRK2 inhibitor 101, Takeda compound 101, Cmpd101) is a novel membrane-permeable, small-molecule inhibitor of GRK2 and GRK3. |
865608-11-3 |
DC10933 |
Compound 3-110-22
Compound 3-110-22 is a small molecule that inhibits dengue virus (DENV) by binding to its envelope protein E. |
|
DC2085 |
Compound 401
Featured
Compound 401 is a cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over FRAP (mTOR) (IC50 = 5.3 µM). |
168425-64-7 |
DC22270 |
Compound 621433144
Compound 621433144 (ZINC000621433144, Z3269026405) is a potent, selective full agonist of the D4 receptor with 2,500-fold subtype selectivity. |
2223169-38-6 |
DC22117 |
Compound 7004
Compound 7004 (IRAK2 mimetic 7004) is a small molecule mimetic of a-helical domain of IRAK2, inhibit IL-33–induced NF-κB transcriptional activity (IC50=9.7 uM) by disrupting Myddosome formation. |
|
DC11164 |
Compound 919278
Compound 919278 is a specific inhibitor of lymphotoxin β receptor (LTβR, IC50=0.169 uM), and TNF receptor superfamily member 12A (FN14)-dependent nuclear translocation of p52 (IC50=0.167 uM) via inhibiting CDK12/CCNK, does not inhibit the TNF-α-mediated nuclear translocation of p65 (RelA). |
2189366-77-4 |
DC8340 |
myo-Inositol,1,2-anhydro-
Featured
Conduritol B Epoxide (CBE) is a specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside. |
6090-95-5 |
DCAPI1091 |
Conivaptan hydrochloride
Featured
Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. |
168626-94-6 |
DC8477 |
VER-49009
Featured
Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. |
558640-51-0 |
DC21345 |
Contezolid
Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL. |
1112968-42-9 |
DC11048 |
Contilisant
Contilisant is a neuroprotective, non-toxic, antioxidant, permeable ligand, showing in vitro pharmacological properties on the selected biological targets (hAChE IC50=0.53 uM. |
2135615-68-6 |