| DC40530 |
(S)-O-Desmethyl Venlafaxine N-Oxide |
(S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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| DC40544 |
O-Desisobutyl-O-n-propyl Febuxostat |
O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an xanthine oxidase inhibitor. |
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| DC40559 |
8-Demethyl Ivabradine |
8-Demethyl Ivabradine is a metabolite of Ivabradine. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker. |
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| DC40579 |
5-Hydroxyferulic acid |
5-Hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrate. |
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| DC40643 |
4-Formylaminoantipyrine |
4-Formylaminoantipyrine?is an excreted metabolite of?aminophenazone. Aminophenazone is a pyrazolone with analgesic, anti-inflammatory, and antipyretic effects in vivo. |
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| DC40687 |
Dichloroiodomethane |
Dichloroiodomethane is a natural compound in human beings. |
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| DC40709 |
(Rac)-Mono(3,5,5-trimethylhexyl) phthalate |
(Rac)-Mono(3,5,5-trimethylhexyl) phthalate is a important metabolite of commonly used phthalate plasticizers. (Rac)-Mono(3,5,5-trimethylhexyl) phthalate has immuno-suppressive effect. |
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| DC40710 |
Mono(5-carboxy-2-ethylpentyl) phthalate |
Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking. |
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| DC40711 |
β-Tocopherol |
β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol. |
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| DC40716 |
2-Aminoflubendazole |
2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of drugs with activities against fungi, protozoa, and helminthes. |
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| DC40726 |
Nordoxepin D3 hydrochloride |
Nordoxepin D3 hydrochloride (Desmethyldoxepin D3 hydrochloride) is the deuterium labeled Nordoxepin hydrochloride. Nordoxepin hydrochloride is an active metabolite of Doxepin hydrochloride, which is an orally active tricyclic antidepressant.
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| DC40730 |
Rivastigmine carbamate impurity |
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. |
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| DC40739 |
Apovincaminic acid hydrochloride salt |
Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action. |
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| DC40740 |
trans-2-Hexadecenoyl-L-carnitine |
trans-2-Hexadecenoyl-L-carnitine is an endogenous metabolite in urine. |
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| DC40741 |
[(3R)-3-Hydroxydodecanoyl]-L-carnitine |
[(3R)-3-Hydroxydodecanoyl]-L-carnitine is an endogenous metabolite. |
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| DC40744 |
(Rac)-Indoximod |
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes. |
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| DC40766 |
3'-Hydroxy Repaglinide D5 |
3'-Hydroxy Repaglinide D5 is the deuterium labeled 3'-Hydroxy Repaglinide. 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. |
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| DC40779 |
NHC-diphosphate |
NHC-diphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form. NHC is a pyrimidine ribonucleoside and behaves as a potent anti-virus agent. NHC effectively inhibits the replication of venezuelan equine encephalitis virus (VEEV), Chikungunya virus (CHIKV) and hepatitis C virus (HCV).
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| DC40784 |
3,4-Dehydro Cilostazol |
3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol. 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
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| DC40863 |
AQX-435 |
AQX-435 is a potent SHIP1 phosphatase activator. AQX-435 reduces PI3K activation downstream of the B-cell receptor (BCR) and induces apoptosis of malignant B cells, and reduces lymphoma growth. |
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| DC40880 |
GS-704277 |
GS-704277 is an alanine metabolite of Remdesivir. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro. |
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| DC40888 |
Tofacitinib metabolite-1 |
Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib.
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| DC40891 |
Simvastatin Acyl-β-D-glucuronide |
Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
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| DC40892 |
(Rac)-3′-Hydroxy simvastatin |
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. |
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| DC40893 |
2-Hydroxy atorvastatin lactone |
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. |
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| DC40894 |
3α-Hydroxy pravastatin sodium |
3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor. |
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| DC40895 |
BRD9500 |
BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC50s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity. |
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| DC40938 |
Ternidazole hydrochloride |
Ternidazole hydrochloride is a hydroxymetabolite of nitroimidazole, has antiprotozoic properties. |
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| DC40939 |
Toltrazuril sulfoxide |
Toltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril, and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
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| DC40963 |
T-705RMP |
T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM. |
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