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(Rac)-Indoximod

  Cat. No.:  DC40744  
Chemical Structure
26988-72-7
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Field of application
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 26988-72-7
Chemical Name: (Rac)-Indoximod
SMILES: NC(CC1=CN(C)C2=C1C=CC=C2)C(O)=O
Formula: C12H14N2O2
M.Wt: 218.25
Sotrage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
MSDS
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MSDS_23757_DC40744_26988-72-7
COA
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Cat. No. Product name Field of application
DC47597 IDO-IN-14 IDO-IN-14 is an IDO inhibitor with an IC50 value of 0.6928 nM.
DC47596 IDO-IN-15 IDO-IN-15 is an IDO1 inhibitor (IC50 < 0.51 nM).
DC46155 BMT-297376 BMT-297376, the optimized Linrodostat, is a potent IDO1 inhibitor.
DC42338 IDO-IN-8 IDO-IN-8 (NLG-1487) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, compound 1487, has an IC50 of 1-10 μM.
DC42337 IDO-IN-6 IDO-IN-6 (NLG-1486) is an indoleamine 2,3-dioxygenase (IDO) extracted from patent WO WO2012142237A1, Compound 1486, has an IC50 of <1 μM.
DC40744 (Rac)-Indoximod (Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
DC28673 IDO1-IN-2 IDO1-IN-2 (compound 16) is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse) and 28 nM (rat), respectively. IDO1-IN-2 has anti-cancer activity.
DC28284 (S)-IDO1-IN-5 (S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC28283 (Rac)-IDO1-IN-5 (Rac)-IDO1-IN-5 (Example 1) is a racemate of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
DC11159 Roxyl-WL Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.
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