| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9934 | GNE-272 | GNE-272 is a in Vivo Probe for the Bromodomains of CBP/EP300. |
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| DC23337 | GNE-2861 | GNE-2861 is a potent, selective group II PAK (PAK4/5/6) inhibitor with IC50 of 7.5/126/36 nM, respectively, shows selectivity over group I PAKs (IC50=5.42/0.97/>10 uM for PAK1/2/3). |
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| DC21057 | GNE-293 | GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively. |
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| DC11845 | GNE-3500 | GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays. |
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| DC12313 | GNE-371 | GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2). |
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| DC23374 | GNE-375 | GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM, displays >480-fold selectivity over BRD4, CECR2, and TAF1. |
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| DC23869 | GNE-431 | GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM and 2.5 nM for WT Btk and C481S mutant, respectively. |
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| DC8257 | GNE 477 Featured | GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kα, Kiapp is 21 nM for mTOR. |
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| DC8502 | GNE-490 Featured | GNE-490 is a highly selective pan-PI3K inhibitor and demonstrates selectivity over mTOR. |
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| DC7953 | GNE-493 Featured | GNE-493 is a potent, selective, and orally available dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/12/16/16/32 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR respectively. |
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| DC11189 | GNE-6468 | GNE-6468 (GNE6468) is a potent and selective RORc inverse agonist (EC50=2 nM) with >1,000-fold selectivity for RORc over PPARγ. |
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| DC11555 | GNE-6776 Featured | GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM . |
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| DC11729 | GNE-781 Featured | GNE-781 is a potent, selective, non-CNS penetrant, orally active CBP/p300 bromodomain inhibitor with IC50 of 0.94/1.2 nM in TR-FRET assays. |
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| DC23165 | GNE-7915 tosylate | GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
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| DC26024 | GNE-8324 Featured | GNE-8324 is a potent and selective NMDA receptor PAM. |
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| DC23350 | GNE-886 | GNE-886 is a potent and selective CECR2 bromodomain inhibitor with IC50 of 16 nM. |
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| DC11732 | GNE-900 | GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM. |
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| DC20074 | GNE-955 | GNE-955 is a potent pan Pim kinase inhibitor with Kis of 18, 110, 8 nM for Pim1, Pim2, Pim3, respectively. |
|
| DC20204 | GNF-6231 | GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM. |
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| DC9285 | GNF-7 Featured | GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively. |
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| DC21060 | GNX-865 | GNX-865 is a potent mitochondrial permeability transition pore (mPTP) inhibitor with EC50 of 105 uM (mitochondrial swelling). |
|
| DC22100 | GO289 Featured | GO289 (GO-289, GO 289) is a potent and selective inhibitor of casein kinase 2 (CK2) with IC50 of 7 nM in in vitro kinase assays, shows minor effects on CKIδ and CKIα activity in vitro. |
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| DC20393 | Golgicide A Featured | Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM. |
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| DC12542 | GOT1 inhibitor 2c Featured | GOT1 inhibitor 2c is a first-in-class, non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with IC50 of 8.2 uM.. |
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| DC9375 | GPDA Featured | GPDA(Glycylproline p-nitroanilide tosylate) is the substarate of X-Prolyl dipeptidyl-aminopeptidase in the enzyme assay. |
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| DC21902 | GPR139 agonist AC4 | GPR139 agonist AC4 is a novel small molecule GPR139 receptor agonist with EC50 of 220 nM in calcium mobilization assay in CHO-GPR139 cells. . |
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| DC20394 | GPR39 modulator 3 | GPR39 modulator 3 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=5 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
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| DC20395 | GPR39 modulator 7 | GPR39 modulator 7 is a Hedgehog pathway inhibitor that has high cellular potency (EC50=20 nM) in the reporter gene assay, activates the orphan receptor GPR39 and potently reduces of Gli1 and Ptch1 mRNA levels. |
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| DC20076 | GPR4 antagonist 3(NE 52-QQ57 ) Featured | GPR4 antagonist 3 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. Anti-inflammatory activities. |
|
| DC11143 | GPR40 AgoPAM AP5 | GPR40 AgoPAM AP5 is a potent, selective GPR40 AgoPAM (full agonist with positive allosteric modulation) with hIP1 EC50 of 0.8 nM, high selectivity over the GPR120 receptor (EC50>30 uM). |
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