| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22224 | Gpr52 antagonist E7 | Gpr52 antagonist E7 (Scabertopin) is a novel Gpr52-specific small molecule antagonist, reduces mutant HTT levels and rescues Huntington's disease-associated phenotypes in cellular and mouse models.. |
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| DC21064 | GR-127935 hydrochloride Featured | GR-127935 potent and selective 5-HT1B/1D receptor antagonist with pKi of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptor. |
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| DC8820 | GR148672X | GR148672X is a specific TGH inhibitor. |
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| DC21065 | GR-64349 | GR-64349 is a potent and selective tachykinin NK2 receptor agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively.. |
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| DC21066 | GR73632 Featured | GR-73632 is a potent and selective tachykinin NK1 receptor agonist with EC50 of 2 nM, promotes differentiation but not survival of rat chromaffin cells in vitro.. |
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| DC9918 | Gracillin | Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent. |
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| DC12095 | GRGDSP TFA | GRGDSP (TFA) is an integrin inhibitor. |
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| DC22629 | GRL-0617 Featured | GRL-0617 is a potent, noncovalent SARS-CoV papain-like protease (PLpro) inhibitor with IC50 of 0.6 uM, Ki of 0.49 uM. |
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| DC23564 | GS 462808 | GS 462808 is a potent Late INa current inhibitor with IC50 of 1.33 uM. |
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| DC21070 | GS-1 | GS-1 is a close structural analog of GS-5806 that acts an RSV fusion inhibitor. |
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| DC21068 | GS-493 | GS-493 is a novel potent, selective SHP2 inhibitor with IC50 of 71±15 nM in enzyme assay. |
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| DC23381 | GS-626510 | GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT. |
|
| DC21071 | GS-9451 | GS-9451 (Vedroprevir) is a potent HCV NS3/4A protease inhibitor with Ki of 0.41 nM, inhibits HCV GT-1b NS3/4A with IC50 of 3.2 nM in enzymatic assays. |
|
| DC23244 | GS-9695 | GS-9695 is a potent, non-catalytic site HIV integrase inhibitor with wild type EC50 of 1.2 nM.. |
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| DC11297 | GS-9822 | GS-9822 is a novel, potent NCINI with a higher barrier to resistance relative to early prototype NCINIs, including GS-9695. |
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| DC23876 | GSA-10 Featured | GSA-10 is a novel small-molecule positive modulator of Smoothened with EC50 of 1.2 uM in the differentiation assay. |
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| DC9515 | PI3K inhibitor GS1059615 | GSK1059615 is a dual inhibitor of PI3Kα/β/δ/γ (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively. |
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| DC7422 | GSK1292263 Featured | GSK1292263 is a novel GPR119 receptor agonist used for the treatment of type 2 diabetes. |
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| DC2069 | IGF-1R inhibitor GS1904529A | GSK1904529A is a selective inhibitor of IGF-1R and IR with IC50 of 27 nM and 25 nM, respectively. |
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| DC9943 | PI3Kδ inhibitor GS2269557 | GSK-2269557 is a potent and selective PI3Kδ inhibitor over the closely related isoforms. |
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| DC9944 | PI3Kδ inhibitor GS2292767 | GSK2292767 is a potent and selective PI3Kδ inhibitor. |
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| DC9712 | Iinerixibat | GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) . |
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| DC7650 | GSK2334470 Featured | GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM, with no activity at other close related AGC-kinases. |
|
| DC8520 | GSK-25 Featured | GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
| DC9719 | Lp-PLA2 -IN-1(GSK2814338) Featured | GSK2814338, also known as Lp-PLA2 -IN-1, is a Lp-PLA2 inhibitor |
|
| DC9721 | GSK2983559 active metabolite Featured | GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 (RIP2) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1. |
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| DC9717 | amyloid P-IN-1(GSK3039294) Featured | GSK3039294 is a Serum amyloid P component inhibitor. |
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| DC10391 | EBI2 inhibitor GS682753A | GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. |
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| DC2070 | GSK690693 Featured | GSK690693 is a pan-Akt inhibitor targeting Akt1, Akt2 and Akt3 with IC50 of 2 nM, 13 nM, and 9 nM, respectively. |
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| DC26130 | GSK8612 Featured | GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1. |
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