| DC21168 |
JNc-440 |
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3. |
|
| DC23538 |
JNJ 10181457 dihydrochloride |
JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3. |
|
| DC23539 |
JNJ 10181457 |
JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3. |
|
| DC23418 |
JNJ 39220675 |
JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3. |
|
| DC7843 |
JNJ 42153605
Featured
|
JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
|
| DC21171 |
JNJ-10198409 |
JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM. |
|
| DC23504 |
JNJ16567083 |
JNJ16567083 (EMQMCM) is a potent and selective mGluR1 antagonist that shows neuroprotective effects in some hypoxia-ischemia models. |
|
| DC7617 |
JNJ-1661010 |
JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. |
|
| DC22665 |
JNJ18038683
Featured
|
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
|
| DC22717 |
JNJ-18038683 free base |
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
|
| DC21910 |
JNJ-1A |
JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity. |
|
| DC11115 |
JNJ-26489112 |
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. |
|
| DC21172 |
JNJ-26993135 |
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM. |
|
| DC22716 |
JNJ-28307474 |
JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.. |
|
| DC21173 |
JNJ-28312141 hydrochloride |
JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM. |
|
| DC22689 |
JNJ-28610244 |
JNJ-28610244 is a potent, selective agonist of histamine H4 receptor (H4R).. |
|
| DC23567 |
JNJ303
Featured
|
JNJ303 is a potent, specific delayed rectifier potassium current I(Ks) blocker with IC50 of 64 nM, shows no effects on other cardiac channels (IC50=3.3, >10, 11.1 and 12.6 uM for Na, ICa, Ito and IKr currents). |
|
| DC22405 |
JNJ-37822681 |
JNJ-37822681 is a potent, specific and fast-dissociating dopamine D2 antagonist with Ki of 158 nM. |
|
| DC8521 |
JNJ-38158471 |
JNJ-38158471(KDR) is a well tolerated, orally available, highly selective VEGFR-2 inhibitor with IC50=40nM. It also inhibits closely related tyrosine kinases, Ret (180nM) and Kit (500nM). It has no significant activity (>1 microM) against VEGFR-1 and VEGF |
|
| DC21440 |
JNJ-38877618 |
JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. |
|
| DC21174 |
JNJ-38893777 |
JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain.. |
|
| DC21175 |
JNJ-38893777 sulfate |
JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain.. |
|
| DC22738 |
JNJ-39393406 |
JNJ-39393406 is a potent, selective positive allosteric α7 nAChR modulator, potentiates a 100 μM choline-induced rise in intracellular calcium mediated by human α7 channels expressed in GH4C1 cells with EC50 of 660 nM. |
|
| DC21176 |
JNJ-39729209 |
JNJ-39729209 is a potent, selective TRPV1 antagonist with binding pKi of 7.8 and 7.9 for human and rat TRPV1, respectively. |
|
| DC22750 |
JNJ-39933673 hemihydrate |
JNJ-39933673 hemihydrate is a potent, selective SGLT2 inhibitor.. |
|
| DC22751 |
JNJ-39933673 |
JNJ-39933673 is a potent, selective SGLT2 inhibitor.. |
|
| DC22683 |
JNJ-40279486 |
JNJ-40279486 is a potent, selective histamine H4 receptor antagonist with Ki of 9.4 nM (hH4), demonstrates acceptable pharmacokinetic profile and efficacy in mouse model of inflammation.. |
|
| DC21178 |
JNJ-40413269 |
JNJ-40413269 is a potent, selective, blood brain barrier (BBB) penetrant FAAH inhibitor with IC50 of 5.3 and 6.3 nM for hFAAH and rFAAH, respectively. |
|
| DC22757 |
JNJ-42314415 |
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A. |
|
| DC21169 |
JNJ-42905343 |
JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively. |
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