Fluorescent probe in vitro and in vivo aiming at a tau-based diagnosis of Alzheimer's disease

Fluorescent probe, binding to neurofibrillary tangles with high contrast and selectivity over amyloid

Fluorescent probe visualizing neurofibrillary tangles in Alzheimer's disease

Novel potent covalent inhibitor of gut bacterial bile salt hydrolases (BSH)

Novel potent inhibitor of both HIV-1 and HIV-2 replication, being also active against the erythrocytic stages of P. falciparum

Novel respiratory syncytial virus (RSV) fusion inhibitor

Novel cell-permeable modulator of cellular morphogenesis in yeast and mammalian cells; Inhibitor of SARS-CoV Mpro activity via intensive H-bond network and hydrophobic interactions

Novel cell-permeable modulator of cellular morphogenesis in yeast and mammalian cells

Novel activator of PC1/3 and inhibitor of PC2

Novel activator of BtGH84, the first experimentally discovered small molecule activator of a glycoside hydrolase

Novel selective and potent competitive inverse agonist of human GPR43

Novel potent and selective covalent inhibitor of Bruton’s tyrosine kinase (BTK), targeting a noncatalytic cysteine residue (Cys481) for covalent bond formation

Novel potent inhibitor of Bruton’s tyrosine kinase (BTK)

The first small-molecule inhibitor with significant selectivity among the KCa2 channel subtypes

Novel inhibitor of alpha2beta1 integrin, decreasing average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C

Novel unique Na V modulator, acting as a conspicuous outlier, eliminating fast but not slow inactivation

Novel effective reversible and noncovalent inhibitor of DprE1.

Negative control for BTZO-1

Ligand of the Imidazoline(2) binding site (I 2 BS), showing very good affinity for the I 2 BS (K i of 1.4 nM; K d = 1.3 nM), good selectivity compared with the α 2 -adrenoceptor (909-fold)

Potent and selective agonist of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor

Direct-acting vasodilator with anti-tachycardiac effect

Bulgecin A is an inhibitor of binuclear metallo-beta-lactamases and Lytic transglycosolase.