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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DCC2871 Jwg-115 Novel BET selective inhibitor, targeting BRD4
DCC2872 Jwh-007 Potent cannabinoid (CB) receptor agonist
DCC2873 Jwu-a021 Novel potent stimulator of glucagon-like peptide-1 (GLP-1) secretion in vitro, also potently stimulating Ca(2+) influx through TRPA1 cation channels, being one of the most potent non-electrophilic TRPA-1 channel agonists
DCC2874 Jxl069 Novel potent mitochondrial pyruvate carrier (MPC) inhibitor to treat hair loss
DCC2875 Jy-1-106 Novel BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak
DCC2876 Jyl-1511 High-affinity partial agonist of the vanilloid receptor
DCC2877 Jyl-273 Potent TRPV1 agonist
DCC2878 Jyl-79 Potent vanilloid receptor (VR1) agonist
DCC2879 Jy-xhe-053 Selective modulator of GABAA receptors containing the α5 subunit
DCC2880 Jz-4109 Novel β-Glucocerebrosidase modulator, promoting dimerization of β-glucocerebrosidase and revealing an allosteric binding site, stabilizing wild-type and N370S mutant GCase and increases GCase abundance in patient-derived fibroblast cells
DCC2881 Jz-5029 Novel irreversible β-Glucocerebrosidase modulator
DCC2882 jzad-iv-22 Inhibitor of all three monoamine transporters
DCC2883 Jzp-430 Potent, highly selective, and irreversible ABHD6 Inhibitor
DCC2884 K00135 Novel potent and selective inhibitor of PIM kinases
DCC2885 K00518 Novel dual CLK1 and CLK3 inhibitor
DCC2886 K103 Hydrochloride Novel inhibitor of peptidoglycan synthesis targeting the lipid II precursor
DCC2887 K-14585 Novel antagonist for proteinase-activated receptor 2 (PAR2)
DCC2888 K4610422 Novel norditerpenoid inhibitor of testosterone-5α-reductase
DCC2889 K-8008 Novel inhibitor of the interaction of the N-terminally truncated RXR
DCC2890 K-8012 Novel inhibitor of the interaction of the N-terminally truncated RXR
DCC2891 Kaempulchraol P Natural anti-inflammatory agent, inhibiting the NF-κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression
DCC2892 Kaempulchraol Q Natural anti-inflammatory agent, inhibiting the NF-κB-mediated transactivation of a luciferase reporter gene, IL-6 production, and COX-2 expression
DCC2893 Kalb001 Novel mGlu4 ligand
DCC2894 Kar425 Novel antimalarial agent, providing protection to malaria-infected mice
DCC2895 Kasugamycin Antibiotic, binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis
DCC2896 Kb130015 Novel activator of hERG1 potassium channels, blocking native and recombinant hERG1 channels at high voltages, but activating them at low voltages
DCC2897 Kbh-a42 Novel histone deacetylase inhibitor
DCC2898 Kbjk557 Novel Plk1 PBD inhibitor, showing a remarkable in vitro anticancer effect by inducing Plk1 delocalization, mitotic arrest, and apoptosis in HeLa cells
DCC2899 Kb-nb165-09 Selective inhibitor of Protein_kinase_D1>protein kinase D (PKD); Inhibitor of cell adhesion and HIV; Inhibitor of herpes simplex virus type 1 replication
DCC2900 Kbp-088 Novel highly potent dual amylin and calcitonin receptor agonist (DACRA), showing long-lasting improvement of food preference and body weight loss

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