| DC7181 |
KPT-276
Featured
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KPT-276, analog of KPT-185, is an orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1. |
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| DC11276 |
KPT-6566
Featured
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KPT-6566 is a covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. |
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| DC26083 |
KR-32570 |
KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM. |
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| DC23568 |
KR-33028 |
KR-33028 is a potent, highly selective NHE1 inhibitor with IC50 of 2.59 uM. |
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| DC12621 |
KR-62436 |
KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively. |
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| DC12652 |
KRAS G12C inhibitor 11 |
KRAS G12C inhibitor 11 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 5 nM. |
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| DC23806 |
KRAS inhibitor 11 |
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM. |
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| DC7446 |
K-Ras(G12C) inhibitor 6 |
K-Ras(G12C) inhibitor 6 is an allosteric, and selective inhibitor of oncogenic K-Ras(G12C). |
 inhibitor 6.gif)
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| DC7722 |
K-RAS inhibitor 9
Featured
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K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C). |
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| DC12704 |
KRAS4b-PDEδ stablizer C19 |
KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells. |
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| DC12588 |
KRAS-G12C inhibitor 13 |
KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays. |
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| DC11375 |
KRIBB3
Featured
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KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner. |
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| DC12186 |
KRN2 bromide |
KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM. |
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| DC22806 |
KS-99 |
KS-99 (KS99) is a novel dual inhibitor of BTK and tubulin polymerization. |
|
| DC22779 |
KSC-34 |
KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site. |
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| DC21205 |
KT-109
Featured
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KT-109 is a potent, selective inhibitor of DAGLβ with IC50 of 42 nM, displays about 60-fold selectivity over DAGLα. |
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| DC21206 |
KT-172 |
KT-172 is a potent, selective inhibitor of DAGLβ with IC50 of 60 nM. |
|
| DC21311 |
KT-195 |
KT-195 is a potent and selective inhibitor of serine hydrolase ABHD6 (α/β-hydrolase domain-containing protein 6) with IC50 of 10 nM. |
|
| DC21207 |
KT-5720 |
KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM). |
|
| DC23732 |
KT-5823
Featured
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KT-5823 is a potent, highly specific PKG (cGMP-dependent protein kinase) inhibitor with Ki of 0.234 uM, displays little to no activity for MLCK, cAPK, and PKC. |
|
| DC7447 |
KU14R |
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. |
|
| DC21208 |
KuWal151 |
KuWal151 is a potent, selective cdc2-like kinase (CLK) inhibitor with IC50 of 88/510/28 nM for CLK1/2/4, respectively. |
|
| DC9860 |
KW-2449 Hydrochloride
Featured
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KW 2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase. |
|
| DC21211 |
KX2-361 |
KX2-361 (KX 02) is a potent, dual Src signaling/tubulin polymerization inhibitor that are under clinical evaluation.. |
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| DC21212 |
KY-02061 |
KY-02061 is a small-molecule inhibitor of Dishevelled-CXXC5 interaction with IC50 of 24 uM in vitro binding assay. |
|
| DC1032 |
KY02111
Featured
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KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting WNT signaling. |
|
| DC21213 |
KY-02327 |
KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog. |
|
| DC21214 |
KY-04045 |
KY-04045 is a novel PAK4 inhibitor with IC50 of 8.7 uM, a basic building block in designing novel imidazo[4,5-b]pyridine-based PAK4 inhibitors.. |
|
| DC22132 |
KY-05009
Featured
|
KY-05009 (KY05009) is a potent, ATP-competitive inhibitor of Traf2- and Nck-interacting kinase (TNIK) with Ki of 100 nM. |
|
| DC9889 |
Kynurenic acid |
Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist. |
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