DC20543 |
San78-130 |
San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277. |
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DC22222 |
SAN9812 |
SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM. |
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DC23030 |
Santalol
Featured
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Santalol has good antibacterial, anti-oxidation and anti-tumor activities. |
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DC20182 |
Sapropterin Dihydrochloride;Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride |
Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. |
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DC22414 |
SAR-216471 hydrochloride |
SAR-216471 is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM. |
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DC12589 |
SAR260301 |
SAR260301 (SAR-260301, SAR 260301) is a potent, selective, ATP-competitive PI3Kβ inhibitor with IC50 of 52 nM in TR-FRET assays, with littile to no actiivty against PI3Kα/γ/δ (IC50=1,869/>10,000/403 nM, respectively). |
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DC10499 |
SAR348830
Featured
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SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK). |
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DC22521 |
SAR405
Featured
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SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM. |
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DCAPI1384 |
Sarafloxacin HCl |
Sarafloxacin HCl |
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DC12047 |
Sarolaner(PF-6450567)
Featured
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Sarolaner is a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs |
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DC9215 |
Sarsasapogenin(Spirostan-3-ol)
Featured
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Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin. |
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DC21605 |
SAS-0132 |
SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors. |
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DC24018 |
Satraplatin |
Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis. |
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DC20051 |
Sauristolactam (Saurolactam) |
Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activ |
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DC9692 |
Volitinib(Savolitinib)
Featured
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Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity. |
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DCAPI1568 |
Saxagliptin Hydrochloride
Featured
|
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. |
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DC12330 |
SB 204990 |
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. |
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DC21608 |
SB 206553 |
SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes. |
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DC9459 |
SB 415286
Featured
|
SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. |
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DC21620 |
SB 737050A |
SB 737050A is a potent, selective 5-HT6 receptor antagonist to prevent relapse intio addiction.. |
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DC22223 |
SB02024
Featured
|
SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro. |
|
DC21611 |
SB-258585 |
SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes. |
|
DC22410 |
SB269652 |
SB269652 is a potent, selective, negative allosteric modulator of dopamine D2 and D3 receptors, abolishes specific binding of [3H]nemanopride and [3H]spiperone to CHO-transfected D3 receptors with IC50 of1.86 and 0.18 nM. |
|
DC8417 |
SB273005 |
SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively. |
|
DC10151 |
SB290157 trifluoroacetate |
SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM. |
|
DC21613 |
SB-399885 hydrochloride |
SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors. |
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DC21614 |
SB-435495 |
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM. |
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DC7278 |
SB-505124
Featured
|
SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
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DC22415 |
SB-612111
Featured
|
SB-612111 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) antagonist with Ki of 0.33 nM. |
|
DC21619 |
SB-699393 |
SB-699393 is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM. |
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