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Other Targets

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Cat. No. Product Name Field of Application Chemical Structure
DC20543 San78-130 San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277.
DC22222 SAN9812 SAN9812 (Carnostatine) is a potent, highly selective, competitive inhibitor of Carnosinase 1 (CN1) activity with Ki of 11 nM.
DC23030 Santalol Featured Santalol has good antibacterial, anti-oxidation and anti-tumor activities.
DC20182 Sapropterin Dihydrochloride;Tetrahydrobiopterin Dihydrochloride, R-THBP Dihydrochloride Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator.
DC22414 SAR-216471 hydrochloride SAR-216471 is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM.
DC12589 SAR260301 SAR260301 (SAR-260301, SAR 260301) is a potent, selective, ATP-competitive PI3Kβ inhibitor with IC50 of 52 nM in TR-FRET assays, with littile to no actiivty against PI3Kα/γ/δ (IC50=1,869/>10,000/403 nM, respectively).
DC10499 SAR348830 Featured SAR348830 is novel potent and selective inhibitor of anaplastic lymphoma kinase (ALK).
DC22521 SAR405 Featured SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM.
DCAPI1384 Sarafloxacin HCl Sarafloxacin HCl
DC12047 Sarolaner(PF-6450567) Featured Sarolaner is a novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs
DC9215 Sarsasapogenin(Spirostan-3-ol) Featured Sarsasapogenin is a steroidal sapogenin, that is the aglycosidic portion of a plant saponin.
DC21605 SAS-0132 SAS-0132 (SAS132) is a novel potent, subtype-selective, brain penetrant sigma 2 receptor/PGRMC1 ligand with Ki of 90 nM, 9-fold selectivity over sigma 1 receptors.
DC24018 Satraplatin Satraplatin (BMS-182751, BMY-45594, JM-216) is a platinum-based antineoplastic agent that binds to guanine residues in DNA, inhibits DNA replication and transcription, leads to subsequent apoptosis.
DC20051 Sauristolactam (Saurolactam) Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells. Sauristolactam also inhibits the receptor activ
DC9692 Volitinib(Savolitinib) Featured Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity.
DCAPI1568 Saxagliptin Hydrochloride Featured Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs.
DC12330 SB 204990 SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
DC21608 SB 206553 SB 206553 is a potent and selective 5-HT2B/5-HT2C receptor antagonist with pA2 of 8.89 for rat 5-HT2B, pKi of 7.92 for human 5-HT2C, displays >80-fold selectivity over other 5-HT receptor subtypes.
DC9459 SB 415286 Featured SB 415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM.
DC21620 SB 737050A SB 737050A is a potent, selective 5-HT6 receptor antagonist to prevent relapse intio addiction..
DC22223 SB02024 Featured SB02024 is a novel highly potent, selective, ATP competitive, orally active inhibitor of vacuolar protein sorting 34 (Vps34) with Kd of 1 nM, >1000 times selective towards other PI3K isoenzymes; SB02024 is also highly selective at 1 uM in the DiscoveRx ScanMax panel of 468 kinases; reduces the number of GFP-2xFYVE puncta with IC50 of 14 nM, induces a dose-dependent increase in levels of NCOA4 and p62; blocks autophagy in vitro and reduces xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7; also significantly potentiates cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro.
DC21611 SB-258585 SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.
DC22410 SB269652 SB269652 is a potent, selective, negative allosteric modulator of dopamine D2 and D3 receptors, abolishes specific binding of [3H]nemanopride and [3H]spiperone to CHO-transfected D3 receptors with IC50 of1.86 and 0.18 nM.
DC8417 SB273005 SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
DC10151 SB290157 trifluoroacetate SB290157 trifluoroacetate is a potent and selective C3a receptor antagonist with an IC50 of 200 nM.
DC21613 SB-399885 hydrochloride SB-399885 is a potent, selective, brain penetrant 5-HT6 receptor antagonist with pKi of 9.11 and 9.02 for human recombinant and native 5-HT6 receptors.
DC21614 SB-435495 SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
DC7278 SB-505124 Featured SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
DC22415 SB-612111 Featured SB-612111 is a potent, selective nociceptin/orphanin FQ receptor (NOP receptor) antagonist with Ki of 0.33 nM.
DC21619 SB-699393 SB-699393 is a potent, selective and CNS penetrant B-Raf inhibitor with Kd of 7.2 nM.

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