DC12467 |
SB772077B |
SB772077B (SB-772077B, SB77, SB-772077-B) is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 5.6 nM and 6.0 nM for ROCK1 and ROCK2, respectively. |
|
DC10148 |
SBC-110736
Featured
|
SBC-110736 is a novel inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9), lowering cholesterol levels in mice. |
|
DC7965 |
SBE 13 hydrochloride
Featured
|
SBE13 Hcl is a potent and selective PLK1 with IC50 of 0.2 nM; no inhibition om Aurora A kinase, Plk2 and Plk3. |
|
DC9546 |
SBE-β-CD |
SBE-β-CD (Sulfobutylether-β-Cyclodextrin; Captisol) is a chemically modified cyclodextrin with a structure designed to optimize the solubility and stability of drugs; Captisol is the trademark of SBE-β-CD registered by Ligand Pharmaceuticals.
|
|
DC10511 |
SBI-0640756
Featured
|
SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. |
|
DC24210 |
SBI-115
Featured
|
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. |
|
DC21624 |
SBI-425
Featured
|
SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM, shows high selectivity over other alkaline phosphatases including IAP and PLAP. |
|
DC21625 |
SBI-477
Featured
|
SBI-477 is a chemical probe that coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes with EC50 of 100 nM and 1 uM, respectively. |
|
DC11283 |
SBI993
Featured
|
SBI-993 is an analog of SBI-477 that shows improved potency and suitable pharmacokinetic properties for in vivo bioavailability |
|
DC10962 |
S-230 |
S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor) with IC50 of 0.12 nM, inhibits 5-oxo-ETE-induced calcium mobilization in human neutrophils.. |
|
DC10961 |
S-C025 |
S-C025 is a highly potent antagonist of oxoeicosanoid receptor (OXE receptor) with IC50 of 0.12 nM. |
|
DC5030 |
SC144
Featured
|
SC144 is an orally active small-molecule gp130 inhibitor. |
|
DC21629 |
SC-236
Featured
|
SC-236 (SC58236) is a potent, selective, orally active inhibitor of COX-2 with IC50 of 10 nM. |
|
DC7281 |
SC-514 (GK 01140)
Featured
|
SC-514 (GK 01140), a small molecule, is a selective inhibitor of IKK-2; does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases. |
|
DC12427 |
SC-68448 |
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3. |
|
DC23426 |
SCH 412348 |
SCH 412348 is a potent and highly selective A2A receptor competitive antagonist with Ki of 0.6 nM. |
|
DC23318 |
SCH 529074
Featured
|
SCH 529074 is a small molecule mutant p53 reactivator that binds p53 DNA binding domain with Kd of 1-2 uM. |
|
DC23823 |
Benzenesulfonamide, n-b-d-glucopyranosyl-4-(hydroxyamino)-n-[2-(2-naphthalenyloxy)ethyl]-
Featured
|
SCH 54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 uM.. |
|
DC23892 |
SCH 900229 |
SCH 900229 is a potent and presenilin 1 selective, and orally active inhibitor of γ-secretase (Aβ40 IC50=1.3 nM). |
|
DC23626 |
SCH-28080
Featured
|
SCH-28080 is a potent, orally active, reversible inhibitor of gastric H+,K+-ATPase with IC50 of 20 nM. |
|
DC11314 |
Sclerotigenin |
Sclerotigenin is a natural diazepine originally isolated from P. sclerotigenum that acts as an insect growth regulator.1 It reduces the growth rate of first instar H. zea larvae by 42% relative to controls when administered in the standard test diet at 20 |
|
DCAPI1371 |
Scopine HCl
Featured
|
Scopine hydrochloride (6,7-Epoxytropine hydrochloride) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. |
|
DC23080 |
Scopolamine
Featured
|
Scopolamine is a high affinity (nM) muscarinic antagonist. 5-HT3 receptor-responses are reversibly inhibited by Scopolamine with an IC50 of 2.09 μM. Scopolamine can cause learning and memory impairments and galantamine can reverse the symptom. It also can |
|
DC23060 |
Scopoletin
Featured
|
Scopoletin exhibits antifungal, anti-allergic, anti-aging, and hypouricemic activities, it exerts anti-RA action probably through suppressing IL-6 production from fibroblast-like synoviocytes via MAPK/PKC/CREB pathways. |
|
DC12667 |
SCR-1481B1(BMS-817378 tris salt)
Featured
|
SCR-1481B1 (c-Met inhibitor 2) is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor. |
|
DC7938 |
SCR7 pyrazine
Featured
|
SCR7 pyrazine is a potent and selective inhibitor of non-homologous end joining (NHEJ),useful tool compound for CRISPR editing. |
|
DC23066 |
Scutellartln
Featured
|
Scutellarein has antioxidant, antitumor, anti-adipogenic, antiviral and anti-inflammatory activities, it can improve neuronal injury, has better protective effect in rat cerebral ischemia. |
|
DC23331 |
Scytonemin |
Scytonemin is a marine natural product that inhibits PLK1 with IC50 of 2 uM against recombinant enzyme, shows similar potentcy for Myt1, Chk1,Cdk1/cyclin B and PKCβ2, less potent against PKA and Tie2. |
|
DC21632 |
SD-1029 |
SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells. |
|
DC8512 |
SD169
Featured
|
SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor. |
|