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Cat. No. Product name CAS No.
DC12707 Hexokinase 2 modulator Comp-1

Hexokinase 2 modulator Comp-1 is a potent, selective small molecule modulator of Hexokinase 2 (HK2) interaction with the mitochondria, selectively dissociates HK2 from VDAC1 in vitro with IC50 of 92 nM.

2055404-90-3
DC21904 HG-12-6

HG-12-6 is a small-molecule inhibitor that bind preferentially to unphosphorylated IRAK4 with IC50 of 165.1 nM, displays 15-fold selectivity over phosphorylated IRAK4 (IC50=2876 nM).

2222354-57-4
DC10652 HG-14-10-04 Featured

HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM.

1356962-34-9
DC23141 HG6-64-1

HG6-64-1 is a potent dual TAK1 and MAP4K2 ((germinal center kinase, GCK)) inhibitor with IC50 of 41 nM and 98 nM, respectively.

1315329-43-1
DC20405 HG-7-27-01

HG-7-27-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 224 nM, displays intermediate selectivity profiles (selectivity score=0.16) against 442 kinases..

1135270-45-9
DC21379 HG-7-92-01(NG25) Featured

HG-7-92-01 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 292 nM, displays intermediate selectivity profiles (selectivity score=0.18) against 353 kinases..

1315355-93-1
DC10108 HG-9-91-01 Featured

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

1456858-58-4
DC26060 gly-arg p-nitroanilide dihydrochloride Featured

H-Gly-Arg-pNA is a colorimetric substrate for thrombin.

125455-61-0
DC8846 HhAntag Featured

HhAntag is a GLI1-Mediated transcription inhibitor.

496794-70-8
DC20406 HIF2α-IN-2

HIF2α-IN-2 is a potent, selective, allosteric inhibitor of HIF-2α PAS-B domain with Kd of 81 nM, shows high selectivity and does not affect HIF-1 function.

1422955-31-4
DC7148 LY 379268 Featured

Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors.

191471-52-0
DC20083 H-Ile-Pro-Pro-OH

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.

26001-32-1
DC23298 Hinokitiol

Hinokitiol (4-Isopropyltropolone.

499-44-5
DC23710 Hippuristanol

Hippuristanol is a potent, steroid inhibitor of eukaryotic initiation factor 4A (eIF4A), results in cell cycle arrest at G1 phase, and induces caspases activation and apoptosis.

80442-78-0
DC10585 Hispidol Featured

Hispidol ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colon epithelial cells with an IC50 of 0.50 µM.

5786-54-9
DC8163 Fostemsavir(BMS-663068) Featured

HIV-1 attachment inhibitor,a prodrug of the small-molecule inhibitor BMS-626529

864953-29-7
DC23258 HIV-1 inhibitor 18A

HIV-1 inhibitor 18A is a novel broad HIV-1 inhibitor that blocks envelope glycoprotein transitions critical for entry, specifically inhibits the entry of a wide range of HIV-1 isolates with mean IC50 of 6.4 uM.

331261-50-8
DC23263 HIV-1 Integrase Inhibitor 7

HIV-1 Integrase Inhibitor 7 is an allosteric HIV-1 integrase inhibitor that inhibits the LEDGF/p75-integrase interaction with IC50 of 0.58 uM, antiviral activity EC50 of 0.76 uM..

1235379-91-5
DC21116 HJC0197 Featured

HJC0197 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.

1383539-73-8
DC21118 HJC 0726

HJC 0726 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.

1449764-45-7
DC21117 HJC-0338

HJC-0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.

1417718-39-8
DC7638 HJC-0350 Featured

HJC-0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.

885434-70-8
DC21119 HL001

HL001 (HL 001) is a potent cyclophilin A (CypA) inhibitor with IC50 of 31.6 nM, induces NSCLC cell cycle arrest and apoptosis via restoring p53 expression.

1186371-31-2
DC21977 HlyU inhibitor CM14

HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.

588678-13-1
DC10414 HM30181(Encequidar) Featured

HM30181 is a potent and selective inhibitor of P-glycoprotein.

849675-66-7
DC12074 HM30181 mesylate Featured

HM30181 mesylate is a competitive and potent P-glycoprotein inhibitor.

849675-87-2
DC10517 HMN-154 Featured

HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

173528-92-2
DC9957 HMN-176 Featured

HMN-176 is a stilbene derivative which inhibits mitosis without significant effect on tubulin polymerization.

173529-10-7
DC20407 HMPC

HMPC is a novel bacteriostatic agent that shows bacteriostatic activity against S. aureus (MIC=4 μg/ml) and rescues Caenorhabditis elegans from S. aureus infection.

128202-97-1
DC22107 HMS-101

HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).

1070690-06-0
DC6314 Icatibant acetate Featured

HOE-140 (Icatibant) is a potent and selective bradykinin B2 receptor antagonist (pA2 = 9.04). Also inhibits aminopeptidase N (Ki = 9.1 μM).

138614-30-9
DC9415 Hoechst 33342 (trihydrochloride)

Hoechst 33342 3Hcl(HOE 33342 3Hcl) is an AT-specific DNA minor groove ligand used fluorochrome for visualizing cellular DNA.

875756-97-1
DC9418 Hoechst 33258 analog

Hoechst stains are part of a family of blue fluorescent dyes used to stain DNA.

258843-62-8
DC22129 HOIPIN-1(JTP-0819958;HOIP inhibitor-1) Featured

HOIPIN-1 (JTP-0819958, HOIP inhibitor-1) is a chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=2.8 uM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the N

DC22108 HOIPIN-8 Featured

HOIPIN-8 (HOIP inhibitor-8) is a potent chemical inhibitor of linear ubiquitin chain assembly complex (LUBAC, IC50=11 nM), specifically generates Met1-linked linear ubiquitin chains through the ubiquitin ligase activity in HOIP, and activates the NF-kB pa

2519537-70-1
DC9650 Homoharringtonine Featured

Homoharringtonine(HHT) is a cytotoxic alkaloid from the evergreen tree.

26833-87-4
DC10177 Homoplantaginin

Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinfammatory and antioxidant properties.

17680-84-1
DC5908 Honokiol Featured

Honokiol(NSC-293100), a hydroxylated biphenyl compound isolated from the Chinese herb Magnolia officinalis, has been reported to have anticancer activities in a variety of cancer cell lines.

35354-74-6
DC12154 Hosenkoside A

Hosenkoside A is a baccharane glycoside isolated from the seeds of impatiens balsamina.

156791-82-1
DC12148 Hosenkoside B

Hosenkoside B is a baccharane glycoside isolated from the seeds of impatiens balsamina.

156764-82-8
DC12152 Hosenkoside F ((+)-Hosenkoside F)

Hosenkoside F is a baccharane glycoside isolated from the seeds of impatiens balsamina.

160896-45-7
DC12153 Hosenkoside K

Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.

160896-49-1
DC12149 Hosenkoside M ((+)-Hosenkoside M)

Hosenkoside M is a baccharane glycoside isolated from the seeds of impatiens balsamina.

161016-51-9
DC23978 hPGDS-IN-1 Featured

hPGDS-IN-1 is a potent, selective hPGDS inhibitor with IC50 of 12 nM in FP or EIA assays..

1234708-04-3
DC23894 HPI-1 Featured

HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).

599150-20-6
DC12616 HS-152

HS-152 (HS152) is a specific small-molecule inhibitor of SMAD ubiquitin regulatory factor 1 (SMURF1), not only potently inhibits SMURF1-mediated RHOB degradation with IC50 of 3.2 uM, but also strongly blocks SMURF1-mediated RHOA and SMAD1 degradation (IC5

DC7426 HS-173 Featured

HS-173 is a potent PI3Kα inhibitor with IC50 of 0.8 nM.

1276110-06-5
DC12632 HS220 Featured

HS220 (HS-220) is a Plasmodium-selective takinib analog that targets atypical P. falciparum protein kinase 9 (PfPK9, Kd=4.1 uM) but does not inhibit HsTAK1, decreases K63-linked ubiquitination in P. falciparum; inhibits P. berghei parasite load in HuH7 ce

1570374-32-1
DC21124 HS-38 Featured

HS-38 is a potent and selective DAPK1 and DAPK3 (ZIPK) inhibitor with IC50 of 200 nM for DAPK1 and Kd of 280 nM for ZIPK, also inhibits Pim3 (IC50=200 nM), and displays no activity against Src or Abl, little activity against EGFR;

1030203-81-6
DC23784 HS-72

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome.

1800285-51-1
DC21126 HSD 1169

HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM).

DC21125 HSD992

HSD992 is a potent, selective CDK2/3 inhibitor with moderate CDK9 inhibition with IC50 of 18 nM, 57 nM and 49 nM for CDK3/cyclin E, CDK2/cyclin A1 and CDK2/cyclin E, respecively.

2222045-50-1
DC20064 HSK0935 (HSK-0935; HSK 0935)

HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities.

1638851-44-1
DC12508 hSMG-1 inhibitor 11e

hSMG-1 inhibitor 11e is a potent, selective hSMG-1 kinase inhibitor with IC50 of <0.05 nM, >900-fold selectivity over mTOR, and no significant activity against CDK1/2..

1402452-10-1
DC12451 hSMG-1 inhibitor 11j

hSMG-1 inhibitor 11j is a potent, selective hSMG-1 kinase inhibitor with IC5 0of 0.11 nM, 455-fold selectivity over mTOR and no activity against CDK1/2.

1402452-15-6
DC20408 HSP27 inhibitor J2

HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells.

2133499-85-9
DC23794 HSP70 modulator 115-7c

HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast.

908074-72-6
DC21149 HT-0712

HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A.

617720-02-2
DC21791 hTG2 inhibitor VA4

hTG2 inhibitor VA4(VA4) is a novel potent, irreversible inhibitor of human tissue transglutaminase (hTG2) with Ki of 12.9 uM, allosterically abolishs its GTP binding ability with a high degree of selectivity and efficiency.

2088001-23-2
DC20409 HTH-01-091

HTH-01-091 is a potent and selective, cell-permeable, ATP-competitive MELK inhibitor with biochemical IC50 of 10.5 nM.

2000209-42-5
DC9960 HTHQ Featured

HTHQ, which is a hydroquinone monoalkyl ether, is a potent anti-oxidative agent, even at low dose levels.

148081-72-5
DC21128 HTS 01037

HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2) with Ki of 0.67 uM.

682741-29-3
DC20081 H-Val-Pro-Pro-OH

H-Val-Pro-Pro-OH, a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM.

58872-39-2
DC10580 hVEGF-IN-1 Featured

hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.

1637443-98-1
DC20281 Hycanthone Featured

Hycanthone, the most potent mutagen in a series of nine thiaxanthenones, is a potent inducer of nuclear immunoreactivity to antinucleoside antibodies in HeLa cells.

3105-97-3
DCAPI1149 Hydralazine HCl

Hydralazine HCl

304-20-1
DC20410 Hydrazinocurcumin Featured

Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets.

131068-23-0
DCAPI1269 Hydrochlorothiazide

Hydrochlorothiazide

58-93-5
DCAPI1198 Hydrocortisone (Cortisol)

Hydrocortisone (Cortisol)

50-23-7
DC10227 Hydroquinidine

Hydroquinidine is an antiarrhythmic agent.

1435-55-8
DC20277 Hydroxyfasudil free base Featured

Hydroxy-Fasudil is a metabolite of Fasudil, acting as a potent Rho-kinase inhibitor and vasodilator.

105628-72-6
DCAPI1226 Hydroxyflutamide (Hydroxyniphtholide)

Hydroxyflutamide (Hydroxyniphtholide)

52806-53-8
DC10848 Hydroxyhexamide Featured

Hydroxyhexamide is a pharmacologically active metabolite of Acetohexamide, used as a hypoglycemic agents.

3168-01-2
DCAPI1045 Hydroxyurea (Cytodrox)

Hydroxyurea (Cytodrox)

127-07-1
DCAPI1564 Hyoscyamine Sulfate

Hyoscyamine Sulfate

6835-16-1
DC9913 Hypericin

Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM.

548-04-9
DC23001 Hypocrellin B Featured

Hypocrellin B is an apoptosis inducer. The hypocrellins are pigments isolated from the fungi Hypocrella bambusae and Shiraia bambusicola. They are used as photosensitizers for photodynamic therapy of cancer.

123940-54-5
DC21129 HZ05

HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo..

2097360-24-0
DC8834 HZ-1157 Featured

HZ-1157 is a novel potent inhibitor of HCV NS3/4A protease; Potent Dengue virus inhibitor

1009734-33-1
DC21130 I-191 Featured

I-191 is a novel potent, selective protease-activated receptor 2 (PAR2) antagonist with pIC50 of 7.2 in cell-based assays.

1690172-25-8
DC11262 IACS-010759 Featured

IACS-010759 (IACS010759) is a small molecule inhibitor of mitochondrial oxidative phosphorylation (OXPHOS), targets complex I of the mitochondrial electron transport chain.

1570496-34-2
DC12105 IACS-10759 Hydrochloride

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).

1807523-99-4
DC21131 IACS-4619

IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.2 nM.

1884209-98-6
DC21132 IACS-4759

IACS-4759 potent, selective aminopyrimidine MTH1 (MutT homolog 1) inhibitor with IC50 of 0.6 nM.

1884209-99-7
DC23352 IACS-7e

IACS-7e is a potent TRIM24 bromodomain inhibitor with IC50 of 217.8 nM (TRIM24 ligand displacement)..

1800477-13-7
DC23361 IACS-9571

IACS-9571 is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.

1800477-30-8
DC23546 IAXO-102

IAXO-102 is a novel selective TLR4 antagonist, negatively regulates non-hematopoietic TLR4 signalling and inhibits experimental AAA development.

1115270-63-7
DC21905 IBET151-VHL-PROTAC

IBET151-VHL-PROTAC is a novel PROTAC..

DC10007 Ibiglustat(Genz-682452) Featured

Ibiglustat (Genz-682452,SAR402671), is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor.

1401090-53-6
DC12341 Ibiglustat succinate (Venglustat (succinate); GZ/SAR402671 (succinate)) Featured

Ibiglustat (succinate) is a selective inhibitor of glucosylceramide synthase.

1629063-78-0
DC7635 IB-MECA Featured

IB-MECA is a potent and selective A3 adenosine receptor agonist (Ki values are 1.1, 54 and 56 nM for A3, A1 and A2A receptors respectively).

152918-18-8
DC21134 IBR2

IBR2 is a novel small molecule RAD51 inhibitor that specifically binds to RAD51 and disrupts the BRC repeats of BRCA2/RAD51 interaction with IC50 of 0.11 uM.

313526-24-8
DC22112 IBS003031

IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays.

381177-81-7
DC8983 Ibudilast Featured

Ibudilast(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor which has been marketed for treating asthma,ibudilast (MN-166) is tested to treat acute respiratory distress syndrome (ARDS) associated with Covid-19.

50847-11-5
DC8573 Ibufenac

Ibufenac is an analog of the NSAID ibuprofen that inhibits COX-1 and -2 activity with IC50 values of 17.4 and 13.1 µM, respectively.

1553-60-2
DC20411 Ibulocydine

Ibulocydine is the prodrug of CDK inhibitor BMK-Y101, inhibits CDK7 and CDK9 with IC50 of 530 nM and 85 nM in kinase assays, respectively.

1314096-68-8
DC9163 Ibutilide fumarate

Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.

122647-32-9
DC21135 IC 86621 Featured

IC 86621 is a potent DNA-PK inhibitor with IC50 of 135 nM, also inhibits p110β (IC50=135 nM), less potent for p110α/γ/δ (IC50=880-1,400 nM).

404009-40-1
DC21136 IC 87361

IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β.

404011-02-5
DC23271 IC-9564

IC-9564 (AIDS033640) is a betulinic acid derivative and potent HIV entry inhibitor that blocks HIV-1 envelope-mediated membrane fusion with IC90 of 0.22 uM for NL4-3 strain.

174847-98-4
DC22114 ICA135

ICA135 (ICA-135, ICA 135) is a broad-spectrum inhibitor against human enteroviruses that inhibits Coxsackievirus A10 (CV-A10) replication in RD cells with IC50 of 1.446 uM.

825601-94-3
DC12286 Icariside I Featured

Icariside I is a metabolite of Icarlin, which could regulate bone remodeling and is recognized as an effective agent for the treatment of osteoporosis.

56725-99-6
DC9789 Icaritin(Anhydroicaritin) Featured

Icaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings.

118525-40-9
DC9639 iCRT 14 Featured

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).

677331-12-3
DC21139 iCRT-5

iCRT-5 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 18 nM.

18623-44-4
DC20601 Idarubicin Featured

Idarubicin Free Base is an orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.

58957-92-9
DC21140 IDD388

IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM)..

314297-26-2
DC9970 IDE-1 Featured

IDE-1 induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM).

1160927-48-9
DC9971 IDE-2 Featured

IDE-2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs).

1136466-93-7
DCAPI1265 Idebenone

Idebenone

58186-27-9
DC20068 IDH1 Inhibitor 1

IDH1 Inhibitor 1 is a potent, orally bioavailable, brain-penetrant and selective mutant IDH1 inhibitor with IC50s of 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT, respectively. Anticancer activity.

2234285-81-3
DC23637 IDRA-21

IDRA-21 is a positive allosteric modulator of the AMPA receptor (AMPAR).

22503-72-6
DC21141 IDX-17119

IDX-17119 is a potent, non-nucleoside, HCV NS5B RdRp inhibitor with IC50 of 0.4 nM in replicon luciferase assay.

1987906-92-2
DC21142 IDX-375

IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.

1256735-81-5
DC24114 IFNAR-IN-1

IFNAR-IN-1 is a nonpeptidic, small molecule inhibitor of IFN-α and IFNAR interaction, specifically inhibits MVA-induced IFN-α responses by BM-pDCs with IC50 of 2-8 uM..

844882-93-5
DC12541 iGOT1-01 Featured

iGOT1-01 is a small molecule inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1 (GOT1)) with IC50 of 11.3 uM.

882256-55-5
DC11051 IGS-1.76

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).

313480-47-6
DC22115 IHVR-19029

IHVR-19029 is a novel antiviral compound that acts as ER α-glucosidase inhibitor, synergistically inhibits the replication of Yellow fever and Ebola viruses in cultured cells combined with favipiravir (T-705).

1447464-73-4
DC21037 IIIC3

IIIC3 (Gallocyanine.

524-26-5
DC21144 IIIM-290

IIIM-290 is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.

2213468-64-3
DC12547 GDC-0214(GDC0214) Featured

GDC0214 is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2.

1831144-46-7
DC20413 IKK2-IN-8

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM).

1266240-87-2
DC20414 IKK2-IN-9

IKK2-IN-9 is a potent, selective and orally active IKK2 inhibitor with IC50 of 19 nM, displays 20-fold selectivity over IKK1 (IC50=420 nM).

1266240-89-4
DC12631 IM176OUT05 Featured

IM176OUT05 is a novel, and safe small molecule that improves the acquisition and maintenance of stem cell pluripotency, inhibits electron transport chain (ETC) in the A549 lung carcinoma cell line with IC50 of 3.2 uM.

1544871-16-0
DC23593 Imagabalin

Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2.

610300-07-7
DC23565 Imagabalin hydrochloride

Imagabalin (PD 0332334) is a novel ligand for the α2δ subunit of the voltage-dependent calcium channel (VDCC) with some selectivity for the α2δ1 subunit over α2δ2.

610300-00-0
DC9242 Imatinib(free base) Featured

Imatinib is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs) and a number of other malignancies.

152459-95-5
DC8678 Imazapic

Imazapic is a selective herbicide for both the preand post-emergent control of some annual and perennial grasses and some broadleaf weeds

104098-48-8
DC20415 Imazaquin

Imazaquin is an imidazolinone herbicide that effectively controls a broad spectrum of weed species, by inhibiting acetohydroxy acid synthase (AHAS)..

81335-37-7
DC23259 IMB-301

IMB-301 (NSC 301209) is a small molecule inhibitor that target the binding interface of the HIV-1 Vif/hA3G complex, inhibits the replication of HIV-1 in H9 cells (IC50=8.63 uM).

64009-84-3
DC23731 iMDK

iMDK is a small molecule inhibitor of the growth factor Midkine (MDK) that suppresses the endogenous expression of MDK but not other growth factors such as PTN or VEGF.

881970-80-5
DC8890 Imidafenacin Featured

Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM).

170105-16-5
DC20211 Imidazole;1,3-diazole; glyoxaline; 1,3-diazacyclopenta-2,4-diene

Imidazole is a heterocyclic aromatic organic compound. It can be incorporated into many important biological molecules and acts as a corrosion inhibitor for industrial applications.

288-32-4
DC22092 Imidazole ketone erastin(IKE) Featured

Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.

1801530-11-9
DC20207 Imidazole-4(5)-acetic Acid Hydrochloride

Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors.

3251-69-2
DC21292 Imipenem

Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains..

64221-86-9
DC8988 Imiquimod Featured

Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.

99011-02-6
DC10406 Imisopasem manganese

Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD.

218791-21-0
DC21145 IMM-01

IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM.

218795-74-5
DC21146 IMM-02

IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM.

218929-99-8
DC10027 Importazole Featured

Importazole is an inhibitor of importin-β transport receptors.

662163-81-7
DC8874 7-TACA

Impurity D of Cefoperazone

37539-03-0
DC12578 IMTPPE Featured

IMTPPE (SID3712502) is a novel small molecule capable of inhibiting androgen receptor (AR) transcriptional activity (IC50=1 uM) and protein level in C4-2 prostate cancer cells.

851688-13-6
DC8450 (R)-Equol

In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively.

221054-79-1
DC23397 INCB054329

INCB054329 is a novel potent, orally bioactive BET inhibitor that inhibits binding of BRD2, BRD3 and BRD4 to an acetylated histone H4 peptide with low nanomolar potency.

1628607-64-6
DC20176 INCB057643 Featured

INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones.

1820889-23-3
DC26025 INCB086550(INCB-086550) Featured

INCB086550 is an orally available, small molecule inhibitor of PD-L1 with potential immune checkpoint inhibitory and antineoplastic activities. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control.

2230911-59-6
DC21497 INCB10820

INCB10820 (PF-4178903) is a potent, selective, orally bioavailable dual CCR2 and CCR5 antagonist with binding IC50 of 3.0 nM and 5.3 nM, respectively.

1310796-72-5
DC11311 Incensole

Incensole is a diterpene originally isolated from frankincense produced by B. carterii.It inhibits degradation of inhibitor of NF-κB (IκBα) in a concentration-dependent manner in TNF-α-stimulated HeLa cells when used at concentrations ranging from 60 to 1

22419-74-5
DCAPI1136 Indapamide (Lozol)

Indapamide (Lozol)

26807-65-8
DC21246 Indimitecan

Indimitecan (LMP776, NSC 725776) is an anticancer DNA Topoisomerase I (Top1) inhibitor..

915360-05-3
DC8906 Indinavir Featured

Indinavir(MK-639; L735524) is a potent and specific HIV protease inhibitor that appears to have good oral bioavailability.

150378-17-9
DC8838 Indirubin Featured

Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 μM and 0.6 μM.

479-41-4
DC20984 Indisulam Featured

Indisulam (E7070) is potent, sulfonamide, cell-cycle inhibitor that possesses antiproliferative activities, causes decrease in the S phase fraction along with G1 and/or G2 accumulation in various cancer cell lines.

165668-41-7
DC23921 Indolactam V

Indolactam V ((-)-Indolactam V) is an indole alkaloid tumor promoter that activates protein kinase C (PKC), binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 uM, respectively.

90365-57-4
DCAPI1311 Indole-3-carbinol Featured

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

700-06-1
DCAPI1237 Indomethacin (Indocid, Indocin)

Indomethacin (Indocid, Indocin)

53-86-1
DC9568 Indoprofen

Indoprofen is a non-steroidal anti-inflammatory drug, provide insight into treatments for spinal muscular atrophies.

31842-01-0
DC20276 Indotecan(LMP400) Featured

Indotecan(LMP400) is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity.

915303-09-2
DC21138 Inflachromene Featured

Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.

908568-01-4
DC9651 Ingenol 3-angelate Featured

Ingenol 3-Angelate is a PKC(protein kinase C)activator; anti-cancer drug and an active ingredient in Euphorbia peplus.

75567-37-2
DC9653 Ingenol 5,20-Acetonide

Ingenol 5,20-Acetonide (CAS 77573-43-4)

77573-43-4
DC9654 Ingenol 5,20-Acetonide-3-O-angelate

Ingenol 5,20-Acetonide-3-O-angelate (CAS 87980-68-5)

87980-68-5
DC9646 Ingenol Featured

Ingenol is an extremely weak protein kinase C (PKC) activator.

30220-46-3
DC9652 Ingenol-3,4:5,20-diacetonide

Ingenol-3,4:5,20-diacetonide (CAS 77573-44-5)

77573-44-5
DC22212 RNF5 INHIBITOR INH-02 Featured

inh-02 (RNF5 inhibitor inh-02) is a novel small molecule inhibitor of E3 ubiquitin ligase RNF5/RMA1.

324579-65-9
DC7640 INH1

INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.

313553-47-8
DC21704 Inh2-B1

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain.

690216-38-7
DC7479 Tiplaxtinin(PAI-039) Featured

Inhibitor of plasminogen activator inhibitor-1 (PAI-1)

393105-53-8
DCAPI1453 IBANDRONATE SODIUM

Inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active and the biphosphonates are used in disorders affecting the skeleton such as metastatic disease, asteoporosis and Paget's.

138926-19-9
DC8132 TAPI-0 (TNF-α processing inhibitor-0)

Inhibits TNF-α processing. Also a general matrix metalloprotease and TACE inhibitor.

143457-40-3
DC23238 INO-1001

INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP) with IC50 of <50 nM in CHO cells.

3544-24-9
DC20417 iNOS inhibitor 12

iNOS inhibitor 12 is a potent, highly selective iNOS inhibitor with IC50 of 79 nM, dispalys almost 100-fold selectivity over eNOS and nNOS..

268730-08-1
DC12101 Insulin levels modulator

Insulin levels modulator could be used to treat diabetes.

1019254-94-4
DC22513 INT-767

INT-767 is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively.

1000403-03-1
DC12106 Interferon receptor agonist

Interferon receptor agonist is an interferonm (IFN) receptor agonist.

2215120-36-6
DCAPI1381 Inulin

Inulin

9005-80-5
DC12160 Iodipamide (Adipiodone)

Iodipamide is a tri-iodinated benzoate derivative and ionic dimeric contrast agent used in diagnostic imaging.

606-17-7
DC20420 Ionomycin calcium salt

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus, used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes.

56092-82-1
DC20419 Ionomycin

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.

56092-81-0
DC9564 Iopamidol

Iopamidol is a nonionic, low-osmolar iodinated contrast agent.

60166-93-0
DC5070 IOX2 Featured

IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.

931398-72-0
DC21756 IP6K1 inhibitor TNP Featured

IP6K1 inhibitor TNP is a potent, selective inositol hexakisphosphate kinase IP6K with IC50 of 0.47 uM (IP6K1), does not inhibit either human or yeast Vip/PPIP5K.

519178-28-0
DC9575 IPA-3

IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).

42521-82-4
DC12599 IPI-9119

IPI-9119 (IPI9119) is a potent, selective, and irreversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.3 nM in biochemical assays.

1346564-56-4
DC20667 Ipidacrine hydrochloride hydrate

Ipidacrine hydrochloride hydrate is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.

118499-70-0
DC20666 Ipidacrine hydrochloride

Ipidacrine hydrochloride is a reversible acetylcholinesterase (AChE) inhibitor that directly stimulates impulse transmission in the central nervous system and neuromuscular synapses by blocking membrane potassium channels.

90043-86-0
DCAPI1117 Ipratropium bromide

Ipratropium bromide

22254-24-6
DC10295 IPSU Featured

IPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.

1373765-19-5
DC23614 IQM-266(IQM 266;IQM266)

IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner.

1956337-58-8
DC21151 IR415

IR415 is a novel small molecule inhibitor of HBV virus replication that blocks hepatitis B virus X protein (HBx, Kd=2 nM) mediated RNAi suppression, reverses the inhibitory effect of HBx protein on activity of the Dicer endoribonuclease.

452967-14-5
DC9493 IRAK inhibitor 6

IRAK inhibitor 6 is interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor .

1042672-97-8
DC23594 Irampanel

Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.

206260-33-5
DC23566 Irampanel hydrochloride

Irampanel (BIIR 561) is a combined antagonist of AMPA receptors (AMPAR) and voltage-dependent sodium channels.

206260-34-6
DC7173 Irbesartan Featured

Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

138402-11-6
DC8771 Tucatinib (Irbinitinib,ARRY-380) Featured

Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold more selective for HER2 versus EGFR.

937263-43-9
DC22411 Irdabisant hydrochloride

Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.

1005398-61-7
DC22419 Irdabisant

Irdabisant (CEP-26401) is a potent, selective, orally active histamine H3 receptor antagonist with Ki of 2 nM and 7 nM for human and rat H3Rs, respectivity.

1005402-19-6
DC20422 IRE1α-IN-3

IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM.

1414938-21-8
DC23051 Irigenin Featured

Irigenin, an α-glucosidase inhibitor, which has anti-inflammatory, anti-cancer, and anti-metastatic effects. Irigenin can inhibit the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and mRNAs without an appreciable

548-76-5
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