| DC74173 |
Siastatin B |
Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases. |
|
| DC74174 |
SJ572946 |
SJ572946 is a small molecule BAK activator, binds to the activation groove of BAK and selectively triggers BAK activation over that of BAX in liposome and mitochondrial permeabilization assays. |
|
| DC74175 |
SMC-21598 |
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3. |
|
| DC74176 |
SMIP004-7 |
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I). |
|
| DC74177 |
SN34960
Featured
|
SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
|
| DC74178 |
SP-8008 |
SP-8008 is a potent, selective inhibitor of shear stress-induced platelet aggregation (SIPA) with IC50 of 1.44 uM, effectively and broadly blocks SIPA events and attenuates platelet activation and aggregation. |
|
| DC74179 |
SPI-0324 |
SPI-0324 (SPI-24) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.52 uM, without affecting WT Htt. |
|
| DC74180 |
SPI-1477 |
SPI-1477 (SPI-77) is a small molecule Spt5-Pol II complex inhibitor (SPI), selectively lowers mutant huntingtin gene (Htt) mRNA level with IC50 of 0.1 nM, without affecting WT Htt. |
|
| DC74181 |
SPI-21 |
SPI-21 (Spt5-Pol II inhibitor 21) is a small-molecule inhibitor of Spt5-Pol II with IC50 of 25.2 uM. |
|
| DC74182 |
SpiD7 |
SpiD7 is a spirocyclic dimer compound that activates the unfolded protein response (UPR), selectively inhibits growth and induce apoptosis of cancer cells. |
|
| DC74183 |
SR-9011 hydrochloride |
A potent, small molecule nuclear receptors REV-ERBα/β agonist with IC50 of 670/800 nM, respectively. |
|
| DC74184 |
SRP-001 |
SRP-001 is a non-opioid and non-hepatotoxic small molecule ApAP analog, induces analgesia via N-arachidonoylphenolamine (AM404) formation, and generates higher amounts of AM404 than ApAP. |
|
| DC74185 |
SS-1-148
Featured
|
SS-1-148 is a potent, selective inhibitor of human ornithine δ-aminotransferase (hOAT) with Ki of 60 uM, shows excellent selectivity over other related aminotransferases (e.g., GABA-AT). |
|
| DC74186 |
SST0871AA1 |
SST0871AA1 is a small molecule Heparanase (Hpse) inhibitor with IC50 of 0.64 uM. |
|
| DC74187 |
SST0872AA1 |
SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM. |
|
| DC74188 |
STF-1084 |
STF-1084 (STF1084) is a potent, cell impermeable, specific, stable, and non-toxic ENPP1 inhibitor with Ki,app of 110 nM (in vitro 32P-cGAMP TLC assay), and cellular IC50 of 340 nM. |
|
| DC74189 |
STOCK1S-14279 |
STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1. |
|
| DC74190 |
Succinyl phosphonate |
Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation. |
|
| DC74191 |
SW088799 |
SW088799 is a small molecule glucagon release inhibitor with IC50 of 1.26 uM, with minimal impact on insulin release. |
|
| DC74192 |
SYNTi |
SYNTi is a small molecule PDZ domain inhibitor targeting the syndecan/syntenin protein-protein interaction with IC50 of 400 nM. |
|
| DC74193 |
Synucleozid hydrochloride |
Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site. |
|
| DC74195 |
TH301 |
TH301 (TH 301) is a selective small molecule stabilizer of Cryptochrome 2 (CRY2).
KL101 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro. |
|
| DC74196 |
TH8535 |
TH8535 (TH-8535) is a potent, selective inhibitor of 8-oxo Guanine DNA Glycosylase 1 (OGG1) with IC50 of 0.2 uM. |
|
| DC74197 |
TMX-4084 |
TMX-4084 (TMX4084) is a highly potent, selective PIP4K2C binder with KD of 7.3 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM). |
|
| DC74198 |
TMX-4102
Featured
|
TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM). |
|
| DC74199 |
TOP5300 |
TOP5300 (TOP05300) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 9.72 nM, 80-fold selectivity over hLHR. |
|
| DC74200 |
TOP5668 |
TOP5668 (TOP05668) is a potent, selective, orally active allosteric agonist of follicle stimulating hormone receptor (FSHR) with EC50 of 2.2 nM, 80-fold selectivity over hLHR. |
|
| DC74201 |
Tpm1.8/9-1 |
Tpm1.8/9-1 (CID 6494468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy. |
|
| DC74202 |
Tpm1.8/9-3 |
Tpm1.8/9-3 (CID 18973468) is a specific small molecule inhibitor of Tpm1.8/9, antagonizes Tpm1.8/9's effects on EMT, Wnt signaling, and resistance to chemotherapy. |
|
| DC74203 |
TR-107
Featured
|
TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
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