| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC74203 | TR-107 Featured | TR-107 (TR107) is a highly potent, selective and orally bioavailable small-molecule activator of the mitochondrial protease ClpP with EC50 of 140 nM, binds to purified ClpP with Kd value of 180 nM in surface plasmon resonance (SPR) measurement. |
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| DC74204 | trans-MiM111 | trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93). |
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| DC74205 | Tryptolinamide Featured | Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive |
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| DC74206 | TTFB | TTFB (ZAC antagonist TTFB) is a selective antagonist (negative allosteric modulator) of Zinc-Activated Channel (ZAC) with IC50 of 3 uM. |
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| DC74207 | TXX-1-10 | TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo. |
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| DC74208 | UAB126 | UAB126 (UAB 126) is a novel rexinoid-like small molecule that show positive effects on metabolic syndrome without the known side effects of potent rexinoids. |
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| DC74209 | UbV SP.1 | UbV SP.1 is potent, selective inhibitor of STAMBP isopeptidase activity with KD of 0.05/0.18 uM for STAMBP/STAMBPL1, respectively. |
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| DC74210 | UbV SP.3 | UbV SP.3 is potent, selective inhibitor of STAMBP isopeptidase activity with KD/IC50 of 60/9.8 nM, with significant preferential binding to STAMBP over STAMBPL1 (250 -fold selectivity). |
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| DC74212 | UNC10245131 | UNC10245131 (UNC 10245131) is a potent, selective cyclic peptide inhibitor of calcium and integrin binding protein 1 (CIB1) with ITC Kd of 6.17 nM. |
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| DC74213 | UNC10245350 | UNC10245351 is a N-terminal HIV Tat conjugate to UNC10245092, a CIB1 peptide inhibitor (Kd=192 nM), cell-penetrating. |
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| DC74214 | UNC2383 | UNC2383 (UNC-2383) is a small molecule that enhances the intracellular delivery and pharmacological effectiveness of antisense oligonucleotides (ONs) and splice switching oligonucleotides (SSOs). |
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| DC74215 | UNC4850 | UNC4850 (UNC-4850) is a specific small-molecule inhibitor toward CDY Chromodomain CDYL1/2 with Kd of 0.47/0.42 uM, >10-fold selectivity over CDY1, CBX5 and CBX7. |
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| DC74216 | UNC5452 | UNC5452 is a selective NIMA-related kinase 1 (Nek1) inhibitor with IC50 of 4.3 uM. |
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| DC74217 | UNC-CA157 | UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B. |
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| DC74218 | UT-59 Featured | UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis. |
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| DC74219 | UTBinh-14 | UTBinh-14 is a potent, highly selective inhibitor for urea transporter UT-B with IC50 of 11 nM, with over a thousand-fold selectivity over UT-A. |
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| DC74220 | VJDT | VJDT (TREM1 inhibitor) is a novel small molecule inhibitor of triggering receptor expressed on myeloid cell 1 (TREM1), effectively blocks TREM1 signaling. |
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| DC74221 | WX-02-37 | WX-02-37 is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.5 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory ar |
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| DC74222 | XEN 602 | XEN 602 (XEN602) is a potent, specific divalent metal transporter 1 (DMT1) inhibitor that inhibits Mn incorporation in HEK293 cells with IC50 of 0.3 nM. |
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| DC74223 | X-Neu5Ac Featured | X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a Km of 0.89 mM for neuraminidase. |
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| DC74224 | XST-20 | XST-20 is a small molecule selectively targeting FOXM1 DNA-binding domain (DBD) with SPR Kd of 20 uM, effectively suppresses FOXM1 transcriptional activities and inhibits ovarian cancer cell proliferation. |
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| DC74225 | YB-537 Featured | YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM). |
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| DC74226 | YE6144 | YE6144 (YE 6144) is a specific small molecule inhibitor of transcription factor IFN regulatory factor 5 (IRF5), selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation. |
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| DC74227 | YL-365 | YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34. |
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| DC74228 | Z839878730 | Z839878730 (KK-LC-1 inhibitor Z8) is a small moelcuel compound targeting KK-LC-1, which is significantly highly expressed in triple-negative breast cancer tissues than in normal breast tissues. |
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| DC74230 | ZHAWOC8697 | ZHAWOC8697 is a small molecule dual inhibitor of sentrin-specific protease SENP1 and SENP2 with IC50 of 8.6 and 2.3 uM, respectively, a valuable tool for the study of SUMOylation processes. |
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| DC74231 | ZINC13407541 | ZINC13407541 is a small molecule antagonist for FGF23, inhibits FGF-23 signaling with IC50 of 0.45 uM. |
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| DC74232 | ZINC16991592 | ZINC16991592 is a selective MRGPRX2 antagonist with Ki of 189 nM. |
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| DC74233 | ZYF0033 | ZYF0033 (ZYF 0033) is potent, selective, small-molecule inhibitor of HPK1 with IC50 of <10 nM based on the phosphorylation inhibition of MBP protein. |
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| DC74234 | ψTnI | ψTnI (Peptide DWRKNIDA) is a selective, high-affinity, eight amino acid peptide inhibitor of cardiac troponin I (cTnI), directly binds to δPKC with high affinity (Kd=5 nM) and inhibits cTnI/δPKC interaction. |
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