CMS121 is a substituted quinoline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.

Histrelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 0.2 nM in CHO cells expressing the human receptor).

4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent.

Antiviral activity against Varicella Zoster

Novel BRD4 inhibitor, suppressing osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

Natural highly potent inhibitor of the serotonin transporter (SERT)

Novel TNKS/2 inhibitor, competing with nicotinamide binding to tankyrases

Natural inhibitor of ERK signaling pathways, inhibiting epithelial-mesenchymal transition via STAT3, showing the growth inhibition of HepG2, HeLa and MGC-803 cancer cell lines

Natural inhibitor of hepatocyte ferroptosis, protecting against drug-induced liver injury

Novel non-nucleoside reverse transcriptase inhibitor (NNRTI)

Inhibitor of VMAT-2, decreasing monamines into synaptic vesicles

Novel potent inhibitor of the CREBBP/EP300 bromodomain, showing >100-fold selectivity over a representative member of the BET bromodomains, BRD4(1)

Natural modulator of miRNA biogenesis, inhibiting the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells

Subtype-selective activator of K(Ca)2.1

MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.

Novel inhibitor of cholesterol transport proteins

Antitumor agent to be associated with negative regulation of Met endosomal signaling in renal cancer cells

Inhibitor of Eukaryotic Translation; Antitumor Natural Product

Moderate alpha-l-fucosidase inhibitor

Natural microbial metabolite of isoflavone genistein, increasing the lifespan and improving the thermal and oxidative stress tolerance of C. elegans

Less active enantiomer of Elexacaftor

Metabolite of VX-740

Vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-​fold greater affinity than GZ-​793A

Inactive control for VinSpinIn

Negative control for EED inhibitor EED226

Negative control compound for UNC3866 which is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).

Negative control for UCSF924

Cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator)

Negative control for TP-004